CAS 923564-51-6

ABT 263

Description:

ABT-263, also known as Navitoclax, is a small molecule inhibitor primarily targeting B-cell lymphoma 2 (Bcl-2) family proteins, which play a crucial role in regulating apoptosis. This compound is characterized by its ability to promote cell death in cancer cells by disrupting the interactions between pro-apoptotic and anti-apoptotic proteins. It is particularly noted for its potential in treating various hematological malignancies, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma. ABT-263 exhibits a relatively low molecular weight and is typically administered orally. Its mechanism of action involves the inhibition of Bcl-2, Bcl-xL, and Bcl-w, leading to the activation of apoptotic pathways. While it shows promise in clinical settings, its use may be limited by side effects such as thrombocytopenia due to its effects on platelets. Ongoing research continues to explore its efficacy in combination therapies and its role in overcoming resistance to other cancer treatments.

Formula: C₄₇H₅₅ClF₃N₅O₆S₃

InChI: InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1

InChI key: InChIKey=JLYAXFNOILIKPP-KXQOOQHDSA-N

SMILES: C(C1=C(CCC(C)(C)C1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC=C(C(NS(=O)(=O)C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C=C5)=O)C=C4

Synonyms:

• 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
• A 855071.0
• Abt-263
• Benzamide, 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-
• Navitoclax

4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide

CAS: 923564-51-6

Formula: C₄₇H₅₅ClF₃N₅O₆S₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 974.6127

Ref: IN-DA0036XG

(R)-4-(4-((4’-Chloro-4,4-Dimethyl-3,4,5,6-Tetrahydro-[1,1’-Biphenyl]-2-Yl)Methyl)Piperazin-1-Yl)-N-((4-((4-Morpholino-1-(Phenylthio)Butan-2-Yl)Amino)-3-((Trifluoromethyl)Sulfonyl)Phenyl)Sulfonyl)Benza

CAS: 923564-51-6

(R)-4-(4-((4’-Chloro-4,4-Dimethyl-3,4,5,6-Tetrahydro-[1,1’-Biphenyl]-2-Yl)Methyl)Piperazin-1-Yl)-N-((4-((4-Morpholino-1-(Phenylthio)Butan-2-Yl)Amino)-3-((Trifluoromethyl)Sulfonyl)Phenyl)Sulfonyl)Benza

Purity: 98%

Molecular weight: 974.61g/mol

Ref: 54-PC108490

Navitoclax

CAS: 923564-51-6

Navitoclax

Purity: ≥95%

Molecular weight: 974.61g/mol

Ref: 54-BUP18009

Navitoclax

CAS: 923564-51-6

View and buy Navitoclax from TargetMol.Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family protein inhibitor that avidly binds Bcl-2.Cited in 4 publications.

Formula: C₄₇H₅₅ClF₃N₅O₆S₃

Purity: 95.82% - >99.99%

Color and Shape: Pale Yellow Solid

Molecular weight: 974.61

Ref: TM-T2101

ABT 263

Controlled Product

CAS: 923564-51-6

Applications A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate. Potent Bcl-2 family inhibitor.
References Adams, J., et al.: Science, 281, 1322 (1998), Degterev, A., et al.: Nat. Cell. Biol., 3, 173 (2001), Kitada, S., et al.: J. Med. Chem., 46, 4259 (2003), Danial, N., et al.: Clin. Cancer Res., 13, 7254 (2007),

Formula: C₄₇H₅₅ClF₃N₅O₆S₃

Color and Shape: Neat

Molecular weight: 974.61

Ref: TR-A112500

Navitoclax

CAS: 923564-51-6

A Bad-like BH3 mimetic with strong affinity for Bcl-xl, Bcl-2 and Bcl-w that promotes BIM-mediated apoptosis. Enhanced efficacy when combined with other chemotherapies in xenograft models of B-cell malignancies and SCLC. Has senolytic effects on senescent cells, demonstrating revival of aged HSCs in vivo.

Formula: C₄₇H₅₅ClF₃N₅O₆S₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 974.62 g/mol

Ref: 3D-FN16901

Navitoclax

CAS: 923564-51-6

Please enquire for more information about Navitoclax including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₄₇H₅₅ClF₃N₅O₆S₃

Purity: Min. 95%

Molecular weight: 974.62 g/mol

Ref: 3D-FA16901