CAS 926037-85-6

Formula: C27H23Cl2F3N8O

InChI: InChI=1S/C27H21F3N8O.2ClH/c1-16-3-4-18(9-23(16)37-26-33-6-5-22(36-26)24-13-31-7-8-32-24)25(39)35-20-10-19(27(28,29)30)11-21(12-20)38-14-17(2)34-15-38;;/h3-15H,1-2H3,(H,35,39)(H,33,36,37);2*1H

InChI key: GEWCZTBAWRSKBX-UHFFFAOYSA-N

SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=NC=CN=C5.Cl.Cl

Radotinib dihydrochloride

CAS: 926037-85-6

Radotinib (IY-5511) dihydrochloride is an orally bioavailable and brain-penetrant selective tyrosine kinase Bcr-Abl1 inhibitor with an IC₅₀ of 34 nM. It exhibits antiprion and antitumor activities by inhibiting tumor cell proliferation, inducing cell cycle arrest, and triggering apoptosis. Radotinib dihydrochloride is applicable in research on chronic myeloid leukemia, multiple myeloma, other tumors, and prion-related neurodegenerative diseases.

Formula: C₂₇H₂₃Cl₂F₃N₈O

Molecular weight: 603.43

Ref: TM-T219231