CAS 927880-90-8

RAF 265

Description:

RAF 265, with the CAS number 927880-90-8, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential as a therapeutic agent. It is classified as a small molecule inhibitor, specifically targeting certain kinases involved in cellular signaling pathways. The compound exhibits properties that may contribute to its efficacy in treating various diseases, including cancer. RAF 265 is known for its ability to inhibit the activity of the RAF kinase family, which plays a crucial role in the MAPK/ERK signaling pathway, often implicated in tumorigenesis. In terms of its physical characteristics, RAF 265 is typically presented as a solid at room temperature, with specific solubility and stability profiles that are relevant for formulation in pharmaceutical applications. Its development has been part of ongoing research aimed at understanding its pharmacokinetics, bioavailability, and overall therapeutic potential. As with many investigational compounds, further studies are essential to fully elucidate its safety and efficacy in clinical settings.

Formula: C₂₄H₁₆F₆N₆O

InChI: InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)

InChI key: YABJJWZLRMPFSI-UHFFFAOYSA-N

SMILES: CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F

Synonyms:

• 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
• Chir 265
• Raf265

Raf265

CAS: 927880-90-8

Raf265

Formula: C₂₄H₁₆F₆N₆O

Purity: 99%

Molecular weight: 518.41

Ref: 54-PC108562

RAF265

CAS: 927880-90-8

RAF265

Formula: C₂₄H₁₆F₆N₆O

Purity: 99.5%

Molecular weight: 518.41

Ref: 54-BUP05536

1-Methyl-5-((2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yl)oxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine

CAS: 927880-90-8

1-Methyl-5-((2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yl)oxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine

Formula: C₂₄H₁₆F₆N₆O

Purity: 99%

Molecular weight: 518.41

Ref: IN-DG306058

RAF265

CAS: 927880-90-8

RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.

Formula: C₂₄H₁₆F₆N₆O

Purity: 99.56%

Color and Shape: White Solid

Molecular weight: 518.4139

Ref: TM-T6296

RAF 265

Controlled Product

CAS: 927880-90-8

Formula: C₂₄H₁₆F₆N₆O

Color and Shape: Neat

Molecular weight: 518.414

Ref: TR-R072900

RAF 265

CAS: 927880-90-8

Inhibitor of RAF kinase

Formula: C₂₄H₁₆F₆N₆O

Purity: Min. 95%

Molecular weight: 518.41 g/mol

Ref: 3D-FR103940