CAS 928037-13-2

Golvatinib

Description:

Golvatinib is a small molecule inhibitor primarily designed to target specific tyrosine kinases, particularly those involved in cancer cell proliferation and survival. It is classified as a kinase inhibitor and has shown potential in the treatment of various malignancies, particularly those with mutations in the MET and VEGFR pathways. The substance exhibits a unique chemical structure that allows it to selectively bind to its target kinases, thereby inhibiting their activity and disrupting downstream signaling pathways that contribute to tumor growth. Golvatinib is typically administered orally and has undergone various phases of clinical trials to evaluate its efficacy and safety profile in cancer patients. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for determining optimal dosing regimens. As with many targeted therapies, potential side effects may include gastrointestinal disturbances, fatigue, and effects on liver function, necessitating careful monitoring during treatment. Overall, Golvatinib represents a promising approach in the field of targeted cancer therapy, aiming to improve outcomes for patients with specific genetic alterations.

Formula: C₃₃H₃₇F₂N₇O₄

InChI: InChI=1S/C33H37F2N7O4/c1-40-16-18-41(19-17-40)24-9-14-42(15-10-24)32(45)39-29-21-26(8-13-36-29)46-25-6-7-28(27(35)20-25)38-31(44)33(11-12-33)30(43)37-23-4-2-22(34)3-5-23/h2-8,13,20-21,24H,9-12,14-19H2,1H3,(H,37,43)(H,38,44)(H,36,39,45)

InChI key: UQRCJCNVNUFYDX-UHFFFAOYSA-N

SMILES: CN1CCN(CC1)C2CCN(CC2)C(=O)NC3=NC=CC(=C3)OC4=CC(=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F

Synonyms:

• N-[2-Fluoro-4-[[2-[[[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl]amino]pyridin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• E-7050
• E7050
• 1,1-Cyclopropanedicarboxamide, N-[2-fluoro-4-[[2-[[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]amino]-4-pyridinyl]oxy]phenyl]-N'-(4-fluorophenyl)-
• N-(2-Fluoro-4-(2-(4-(4-methylpiperazin-1-yl)piperidine-1-carboxamido)pyridin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Golvatinib (E7050)

CAS: 928037-13-2

Formula: C₃₃H₃₇F₂N₇O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 633.6882

Ref: IN-DA00GU35

N-(2-Fluoro-4-((2-(4-(4-Methylpiperazin-1-Yl)Piperidine-1-Carboxamido)Pyridin-4-Yl)Oxy)Phenyl)-N-(4-Fluorophenyl)Cyclopropane-1,1-Dicarboxamide

CAS: 928037-13-2

N-(2-Fluoro-4-((2-(4-(4-Methylpiperazin-1-Yl)Piperidine-1-Carboxamido)Pyridin-4-Yl)Oxy)Phenyl)-N-(4-Fluorophenyl)Cyclopropane-1,1-Dicarboxamide

Purity: 99%

Molecular weight: 633.69g/mol

Ref: 54-PC108620

Golvatinib

CAS: 928037-13-2

Golvatinib

Formula: C₃₃H₃₇F₂N₇O₄

Purity: ≥95%

Molecular weight: 633.69

Ref: 54-BUP10099

Golvatinib

CAS: 928037-13-2

N-(2-Fluoro-4-((2-(4-(4-methylpiperazin-1-yl)piperidine-1-carboxamido)pyridin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Formula: C₃₃H₃₇F₂N₇O₄

Purity: 98%

Molecular weight: 633.69

Ref: IN-DG304673

Golvatinib

CAS: 928037-13-2

Golvatinib (E-7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor

Formula: C₃₃H₃₇F₂N₇O₄

Purity: 98.24% - 99.93%

Color and Shape: Solid

Molecular weight: 633.6882

Ref: TM-T6517

GOLVATINIB

CAS: 928037-13-2

Purity: 98%

Molecular weight: 633.7009888

Ref: 10-F794406

Golvatinib

Controlled Product

CAS: 928037-13-2

Applications Golvatinib is a potent and orally available inhibitor of c-MET and VEGFR-2 that exhibits potential antitumor properties by suppressing the overexpression of these receptor tyrosine kinases.
References Nakagawa, T., et al.: Cancer. Sci., 101, 210 (2010); Wang, W., et al.: Clin. Cancer. Res., 18, 1663 (2012);

Formula: C₃₃H₃₇F₂N₇O₄

Color and Shape: Neat

Molecular weight: 633.69

Ref: TR-G410700