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CAS 928037-13-2

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Golvatinib

Description:
Golvatinib is a small molecule inhibitor primarily designed to target specific tyrosine kinases, particularly those involved in cancer cell proliferation and survival. It is classified as a kinase inhibitor and has shown potential in the treatment of various malignancies, particularly those with mutations in the MET and VEGFR pathways. The substance exhibits a unique chemical structure that allows it to selectively bind to its target kinases, thereby inhibiting their activity and disrupting downstream signaling pathways that contribute to tumor growth. Golvatinib is typically administered orally and has undergone various phases of clinical trials to evaluate its efficacy and safety profile in cancer patients. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for determining optimal dosing regimens. As with many targeted therapies, potential side effects may include gastrointestinal disturbances, fatigue, and effects on liver function, necessitating careful monitoring during treatment. Overall, Golvatinib represents a promising approach in the field of targeted cancer therapy, aiming to improve outcomes for patients with specific genetic alterations.
Formula:C33H37F2N7O4
InChI:InChI=1S/C33H37F2N7O4/c1-40-16-18-41(19-17-40)24-9-14-42(15-10-24)32(45)39-29-21-26(8-13-36-29)46-25-6-7-28(27(35)20-25)38-31(44)33(11-12-33)30(43)37-23-4-2-22(34)3-5-23/h2-8,13,20-21,24H,9-12,14-19H2,1H3,(H,37,43)(H,38,44)(H,36,39,45)
InChI key:UQRCJCNVNUFYDX-UHFFFAOYSA-N
SMILES:CN1CCN(CC1)C2CCN(CC2)C(=O)NC3=NC=CC(=C3)OC4=CC(=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
Synonyms:
  • N-[2-Fluoro-4-[[2-[[[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl]amino]pyridin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
  • E-7050
  • E7050
  • 1,1-Cyclopropanedicarboxamide, N-[2-fluoro-4-[[2-[[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]amino]-4-pyridinyl]oxy]phenyl]-N'-(4-fluorophenyl)-
  • N-(2-Fluoro-4-(2-(4-(4-methylpiperazin-1-yl)piperidine-1-carboxamido)pyridin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
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