CAS 92823-03-5

Flomoxef sodium

Description:

Flomoxef sodium is a broad-spectrum cephalosporin antibiotic, primarily used for its antibacterial properties. It is effective against a variety of Gram-positive and Gram-negative bacteria, making it useful in treating infections caused by these pathogens. The compound is characterized by its ability to resist hydrolysis by certain beta-lactamases, which enhances its efficacy against resistant bacterial strains. Flomoxef sodium is typically administered via injection and is known for its relatively low toxicity profile. Its pharmacokinetics include good tissue penetration and a favorable half-life, allowing for effective dosing regimens. The substance is often utilized in clinical settings for treating respiratory tract infections, urinary tract infections, and skin infections. As with any antibiotic, the potential for resistance development necessitates careful consideration of its use, and it is important to follow guidelines for appropriate prescribing to mitigate this risk. Overall, Flomoxef sodium represents a valuable option in the arsenal of antimicrobial therapies.

Formula: C₁₅H₁₈F₂N₆O₇S₂·Na

InChI: InChI=1S/C15H18F2N6O7S2.Na/c1-29-15(18-8(25)6-31-13(16)17)11(28)23-9(10(26)27)7(4-30-12(15)23)5-32-14-19-20-21-22(14)2-3-24;/h12-13,24H,2-6H2,1H3,(H,18,25)(H,26,27);/t12-,15+;/m1./s1

InChI key: InChIKey=SYHZUFMYQQRMKT-YLCXCWDSSA-N

SMILES: N(C(CSC(F)F)=O)[C@@]1(OC)[C@@]2(N(C1=O)C(C(O)=O)=C(CSC=3N(CCO)N=NN3)CO2)[H].[Na]

Synonyms:

• 5-Oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((((difluoromethyl)thio)acetyl)amino)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-, monosodium salt, cis-
• 5-Oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(2-((difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-, sodium salt,(6R,7R)-
• 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, monosodium salt, (6R,7R)-
• 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, monosodium salt, (6R-cis)-
• 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, sodium salt (1:1), (6R,7R)-
• 6315 S Shionogi
• 6315S
• Flomoxef sodium salt
• Flumarin
• sodium (6R,7R)-7-({[(difluoromethyl)sulfanyl]acetyl}amino)-3-({[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]sulfanyl}methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Sodium (6R,7R)-7-(2-((difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

CAS: 92823-03-5

Sodium (6R,7R)-7-(2-((difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Formula: C₁₅H₁₇F₂N₆NaO₇S₂

Purity: 98%

Molecular weight: 518.45

Ref: 54-PC1033142

Flomoxef Sodium Salt

CAS: 92823-03-5

Formula: C₁₅H₁₇F₂N₆O₇S₂·Na

Color and Shape: White To Off-White Solid

Molecular weight: 495.45 22.99

Ref: 4Z-F-107001

Sodium (6R,7R)-7-(2-((difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

CAS: 92823-03-5

Formula: C₁₅H₁₇F₂N₆NaO₇S₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 518.4481

Ref: IN-DA00GRA2

Flomoxef Sodium

Controlled Product

CAS: 92823-03-5

Stability Hygroscopic
Applications Flomoxef Sodium is a sodium salt derivative of Flomoxef (F401850); an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.
References Miwa, H. et al.: Chemotherapy, 35, 121 (1987); Mikamo, H. et al.: Curr. Therap. Res., 56, 873 (1995);

Formula: C₁₅H₁₇F₂N₆NaO₇S₂

Color and Shape: Neat

Molecular weight: 518.45

Ref: TR-F403000

Flomoxef Sodium - Bio-X ™

CAS: 92823-03-5

Flomoxef sodium is a water-soluble second/fourth-generation cephalosporin, Shionogi β-lactam antibiotic. Flomoxef inhibits bacterial growth through inhibition of cell wall biosynthesis. It has been shown to be effective against infections caused by Streptococcus pneumoniae, Enterobacter aerogenes, and Acinetobacter baumannii among other bacteria, and can be used to treat ongoing infections or as a prophylactic for example ahead of surgery. Flomoxef sodium has been shown to have synergistic effects when used in combination with isepamicin sulfate and penicillin, which may be due to its ability to increase the permeability of the bacterial cell membrane. Clinical trials are currently underway for flomoxef sodium as a treatment for MRSA infections and UTIs. 
Flomoxef Sodium is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₅H₁₈F₂N₆O₇S₂•Na

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 519.46 g/mol

Ref: 3D-BF300080

Flomoxef Sodium

CAS: 92823-03-5

Flomoxef sodium is a water-soluble prodrug with antibacterial activity that is converted to the active form, flomoxef. Flomoxef sodium inhibits bacterial growth by binding to penicillin-binding proteins and inhibiting cell wall synthesis. It has been shown to be effective against infections caused by Streptococcus pneumoniae, Enterobacter aerogenes, and Acinetobacter baumannii. Flomoxef sodium has been shown to have synergistic effects when used in combination with isepamicin sulfate and penicillin, which may be due to its ability to increase the permeability of the bacterial cell membrane. Clinical trials are currently underway for flomoxef sodium as a treatment for MRSA infections.

Formula: C₁₅H₁₇F₂N₆NaO₇S₂

Color and Shape: White Powder

Molecular weight: 518.45 g/mol

Ref: 3D-FF41634

Flomoxef sodium

CAS: 92823-03-5

Formula: C₁₅H₁₇F₂N₆NaO₇S₂

Molecular weight: 518.5

Ref: BE-RMCF085001

Flomoxef sodium

CAS: 92823-03-5

Flomoxef sodium, an antibiotic belonging to the oxacephem group, exhibits excellent activity against a broad spectrum of Gram-positive bacteria.

Formula: C₁₅H₁₇F₂N₆NaO₇S₂

Purity: 99.28%

Color and Shape: White Solid

Molecular weight: 518.44

Ref: TM-T11301L

Flomoxef Sodium Salt

CAS: 92823-03-5

Formula: C₁₅H₁₇F₂N₆O₇S₂Na

Molecular weight: 495.45 : 23.0

Ref: ST-EA-CP-F143003