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CAS 929016-96-6

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Pracinostat

Description:
Pracinostat is a small molecule classified as a histone deacetylase (HDAC) inhibitor, primarily investigated for its potential therapeutic applications in cancer treatment. It is known to modulate gene expression by altering the acetylation status of histones, which can lead to the reactivation of tumor suppressor genes and the induction of apoptosis in cancer cells. Pracinostat has shown promise in preclinical studies and clinical trials, particularly in combination with other therapies for hematological malignancies and solid tumors. Its chemical structure features a specific arrangement of functional groups that contribute to its biological activity. The substance is typically administered orally and has been evaluated for its safety and efficacy in various cancer types. As with many HDAC inhibitors, potential side effects may include gastrointestinal disturbances, fatigue, and hematological changes. Ongoing research continues to explore its full therapeutic potential and mechanisms of action in oncology.
Formula:C20H30N4O2
InChI:InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
InChI key:InChIKey=JHDKZFFAIZKUCU-ZRDIBKRKSA-N
SMILES:C(CN(CC)CC)N1C=2C(N=C1CCCC)=CC(/C=C/C(NO)=O)=CC2
Synonyms:
  • (2E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2-propenamide
  • (2E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxyacrylamide
  • (E)-3-[2-Butyl-1-(2-diethylaminoethyl)-1H-benzimidazol-5-yl]-N-hydroxy-2-propenamide
  • 2-Propenamide, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-, (2E)-
  • Sb 939
  • Sb939
  • Pracinostat
Found 8 products.