CAS 934660-93-2

Cobimetinib

Description:

Cobimetinib is a small molecule inhibitor primarily used in cancer therapy, particularly for the treatment of melanoma. It functions as a selective inhibitor of the mitogen-activated protein kinase (MAPK) pathway, specifically targeting MEK1 and MEK2 enzymes, which play crucial roles in cell proliferation and survival. The chemical formula of cobimetinib is C16H15ClF2N3O2, and it has a molecular weight of approximately 359.76 g/mol. Cobimetinib is typically administered orally and is often used in combination with other therapies, such as vemurafenib, to enhance therapeutic efficacy. Its mechanism of action involves blocking the signaling pathways that promote tumor growth, thereby inhibiting cancer cell proliferation. The substance is characterized by its moderate solubility in organic solvents and relatively low solubility in water. Side effects may include gastrointestinal disturbances, skin reactions, and liver enzyme elevations, necessitating careful monitoring during treatment. Cobimetinib is marketed under the brand name Cotellic and has been approved for use in specific patient populations based on genetic markers.

Formula: C₂₁H₂₁F₃IN₃O₂

InChI: InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1

InChI key: InChIKey=BSMCAPRUBJMWDF-KRWDZBQOSA-N

SMILES: C(=O)(C1=C(NC2=C(F)C=C(I)C=C2)C(F)=C(F)C=C1)N3C[C@](O)(C3)[C@@H]4CCCCN4

Synonyms:

• (S)-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone
• Gdc-0973
• Methanone, [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-(2S)-2-piperidinyl-1-azetidinyl]-
• Rg 7421
• Rg7421
• Xl 518
• [3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone
• [3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-(2S)-2-piperidinyl-1-azetidinyl]methanone
• Cobimetinib
• Cobimetinib

XL518

CAS: 934660-93-2

Formula: C₂₁H₂₁F₃IN₃O₂

Purity: %

Color and Shape: Solid

Molecular weight: 531.3100

Ref: IN-DA00GU2J

Cobimetinib

CAS: 934660-93-2

Cobimetinib

Purity: ≥98%

Molecular weight: 531.31g/mol

Ref: 54-BUP07069

Cobimetinib

CAS: 934660-93-2

Cobimetinib (GDC-0973) is a MEK1 inhibitor with selective and oral activity. Cobimetinib exhibits antitumor activity. Cost-effective and quality-assured.

Formula: C₂₁H₂₁F₃IN₃O₂

Purity: 98% - 99.61%

Color and Shape: Solid

Molecular weight: 531.31

Ref: TM-T3623

Cobimetinib-d9

CAS: 934660-93-2

Formula: C₂₁H₁₂D₉F₃IN₃O₂

Molecular weight: 540.37

Ref: 4Z-C-300002

Cobimetinib

CAS: 934660-93-2

Formula: C₂₁H₂₁F₃IN₃O₂

Molecular weight: 531.32

Ref: 4Z-C-300001

Cobimetinib

CAS: 934660-93-2

Inhibitor of MEK kinase

Formula: C₂₁H₂₁F₃IN₃O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 531.31 g/mol

Ref: 3D-FD28742

XL518-d4

Controlled Product

CAS: 934660-93-2

Formula: C₂₁D₄H₁₇F₃IN₃O₂

Color and Shape: Neat

Molecular weight: 535.335

Ref: TR-X746251

XL518

Controlled Product

CAS: 934660-93-2

Applications A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.
References Rosen, L.S. et al.: J. Clin. Oncol., 26, 14585 (2008);

Formula: C₂₁H₂₁F₃IN₃O₂

Color and Shape: White To Off-White

Molecular weight: 531.31

Ref: TR-X746250