CAS 935888-69-0

Oprozomib

Description:

Oprozomib is a small molecule inhibitor primarily known for its role in the treatment of multiple myeloma and other malignancies. It functions as a proteasome inhibitor, disrupting the proteasome's ability to degrade ubiquitinated proteins, which leads to the accumulation of pro-apoptotic factors and ultimately induces cancer cell death. Oprozomib is characterized by its ability to penetrate tissues effectively and its oral bioavailability, making it a convenient option for patients. The compound has a specific chemical structure that includes a core structure typical of proteasome inhibitors, which contributes to its mechanism of action. Additionally, it has been studied for its potential to overcome resistance to other proteasome inhibitors, showcasing its importance in therapeutic strategies. As with many pharmacological agents, the efficacy and safety profile of Oprozomib are evaluated through clinical trials, which assess its impact on tumor response and overall patient outcomes. Its development reflects ongoing efforts to enhance cancer treatment modalities and improve patient quality of life.

Formula: C₂₅H₃₂N₄O₇S

InChI: InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1

InChI key: InChIKey=SWZXEVABPLUDIO-WSZYKNRRSA-N

SMILES: C([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC(=O)C2=CN=C(C)S2)COC)=O)COC)=O)(=O)[C@@]3(C)CO3

Synonyms:

• ONX 0912
• Oprozomib
• O-Methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-serinamide
• PR 047
• L-Serinamide, O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-

ONX-0912

CAS: 935888-69-0

Formula: C₂₅H₃₂N₄O₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 532.6092

Ref: IN-DA00GU55

Oprozomib

CAS: 935888-69-0

Oprozomib

Purity: ≥98%

Molecular weight: 532.61g/mol

Ref: 54-BUP01519

Oprozomib

CAS: 935888-69-0

Formula: C₁₅H₃₂N₄O₇S

Color and Shape: White To Off-White Solid

Molecular weight: 532.62

Ref: 4Z-O-051001

Oprozomib-d6

CAS: 935888-69-0

Formula: C₁₅H₂₆N₄O₇SD₆

Molecular weight: 538.66

Ref: 4Z-O-051002

Oprozomib

CAS: 935888-69-0

Oprozomib inhibits 20S proteasome β5/LMP7, is orally available, and may have cancer-fighting properties. IC50: β5 - 36 nM; LMP7 - 82 nM.

Formula: C₂₅H₃₂N₄O₇S

Purity: 98% - 99.87%

Color and Shape: Solid

Molecular weight: 532.61

Ref: TM-T6041

Oprozomib [ONX 0912]

CAS: 935888-69-0

Ref: 7W-GW2060

Oprozomib

CAS: 935888-69-0

Proteosome inhibitor; pro-apoptotic; has anti-myeloma activity

Formula: C₂₅H₃₂N₄O₇S

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 532.61 g/mol

Ref: 3D-FO65113

Oprozomib

CAS: 935888-69-0

Purity: 98%

Molecular weight: 532.61

Ref: 10-F979022

Oprozomib

Controlled Product

CAS: 935888-69-0

Applications Oprozomib is the second class of proteasome inhibitors with higher specificities and reduced toxicities, against head and neck squamous cell carcinoma.
References Zang, Y., et al.: Autophagy., 8, 1837 (2012); Zang, Y., et al.: Clin. Cancer. Res., 18, 5639 (2012); Mato, A.R., et al.: Oncologist., 17, 694 (2012); Zhou, H.J., et al.: J. Med. Chem., 52, 3028 (2009);

Formula: C₂₅H₃₂N₄O₇S

Color and Shape: Neat

Molecular weight: 532.61

Ref: TR-O669700