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CAS 935888-69-0

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Oprozomib

Description:
Oprozomib is a small molecule inhibitor primarily known for its role in the treatment of multiple myeloma and other malignancies. It functions as a proteasome inhibitor, disrupting the proteasome's ability to degrade ubiquitinated proteins, which leads to the accumulation of pro-apoptotic factors and ultimately induces cancer cell death. Oprozomib is characterized by its ability to penetrate tissues effectively and its oral bioavailability, making it a convenient option for patients. The compound has a specific chemical structure that includes a core structure typical of proteasome inhibitors, which contributes to its mechanism of action. Additionally, it has been studied for its potential to overcome resistance to other proteasome inhibitors, showcasing its importance in therapeutic strategies. As with many pharmacological agents, the efficacy and safety profile of Oprozomib are evaluated through clinical trials, which assess its impact on tumor response and overall patient outcomes. Its development reflects ongoing efforts to enhance cancer treatment modalities and improve patient quality of life.
Formula:C25H32N4O7S
InChI:InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1
InChI key:InChIKey=SWZXEVABPLUDIO-WSZYKNRRSA-N
SMILES:C([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC(=O)C2=CN=C(C)S2)COC)=O)COC)=O)(=O)[C@@]3(C)CO3
Synonyms:
  • ONX 0912
  • Oprozomib
  • O-Methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-serinamide
  • PR 047
  • L-Serinamide, O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-
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