CAS 93939-70-9

Adenosine 5′-(tetrahydrogen triphosphate), 2′,3′-dideoxy-, trilithium salt

Description:

Adenosine 5′-(tetrahydrogen triphosphate), 2′,3′-dideoxy-, trilithium salt, commonly referred to as dideoxy ATP, is a nucleotide analog that plays a significant role in biochemical research, particularly in studies involving DNA synthesis and enzymatic reactions. This compound is characterized by its structure, which includes an adenosine moiety linked to a triphosphate group, with modifications that prevent the incorporation of the nucleotide into DNA strands during replication. The trilithium salt form indicates that the compound is neutralized with lithium ions, enhancing its solubility in aqueous solutions. Dideoxy ATP is often utilized in molecular biology applications, such as DNA sequencing and polymerase chain reactions (PCR), due to its ability to terminate DNA strand elongation. Its unique properties stem from the absence of a hydroxyl group at the 2′ and 3′ positions of the ribose sugar, which is crucial for its function as a chain terminator. Overall, dideoxy ATP is a valuable tool in genetic research and biochemistry.

Formula: C₁₀H₁₃Li₃N₅O₁₁P₃

InChI: InChI=1S/C10H16N5O11P3.3Li/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18);;;/t6-,7+;;;/m0.../s1

InChI key: InChIKey=FJCJBJSLNQTWSV-PXJNTPRPSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)CC3)=NC=N1.[Li]

Synonyms:

• 2,3-Dideoxyadenosine triphosphoric acid trilithium salt = ddATP-Li3
• Adenosine 5′-(tetrahydrogen triphosphate), 2′,3′-dideoxy-, trilithium salt
• 2'',3''-DIDEOXYADENOSINE 5''-TRIPHOSPHORIC ACID TRILITHIUM SALT (DDATP)
• 2'',3''-Dideoxyadenosine-5''-triphosphoric acid trilithium salt
• 2',3'-dideoxyadenosine 5'-triphosphate trilithium salt
• 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE LITHIUM SALT
• 2',3'-Dideoxyadenosine 5'-Triphosphate lithurn Salt
• 2',3'-DIDEOXYADENOSINE 5'-TRIPHOSPHATE*L ITHIUM 10 M
• Adenosine 5'-(tetrahydrogen triphosphate), 2',3'-dideoxy-, trilithium salt
• ddATP-Li3
• 2',3'-DIDEOXYADENOSINE 5'-TRIPHOSPHATE TRI-LI-SALT*

2',3'-Dideoxyadenosine-5'-triphosphate lithium salt - 100mM aqueous solution

CAS: 93939-70-9

2',3'-Dideoxyadenosine-5'-triphosphate lithium salt is a novel antiviral nucleoside that has the potential to be used in the treatment of various viral infections. It is synthesized from 2',3'-dideoxyadenosine monophosphate and lithium salt, and has been shown to have high antiviral activity against DNA viruses such as herpes simplex virus and adenovirus. It also inhibits the replication of RNA viruses such as influenza A virus, vesicular stomatitis virus, and measles virus. 2',3'-Dideoxyadenosine-5'-triphosphate lithium salt is a modified nucleoside that is phosphoramidite activated with a group at the 2' position on the ribose sugar. The phosphate group can be removed by hydrolysis or enzymatic catalysis, which leaves behind an unsaturated sugar moiety. This leads to an increased rate of incorporation into

Formula: C₁₀H₁₂N₅O₁₁P₃·4Li

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 498.91 g/mol

Ref: 3D-ND32077

2',3'-Dideoxyadenosine-5'-triphosphate lithium salt

CAS: 93939-70-9

2',3'-Dideoxyadenosine-5'-triphosphate lithium salt is a nucleoside for use in research applications

Formula: C₁₀H₁₆N₅O₁₁P₃·xLi

Purity: Min. 95%

Color and Shape: Clear liquid.

Molecular weight: 475.18 g/mol

Ref: 3D-ND10279