CAS 93957-54-1

Fluvastatin

Description:

Fluvastatin is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular diseases. Its chemical structure features a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, which plays a crucial role in cholesterol biosynthesis. The substance is characterized by its ability to lower low-density lipoprotein (LDL) cholesterol levels while modestly increasing high-density lipoprotein (HDL) cholesterol. Fluvastatin is typically administered orally and is known for its relatively short half-life compared to other statins, necessitating dosing adjustments based on individual patient needs. Common side effects may include gastrointestinal disturbances, muscle pain, and, in rare cases, liver enzyme elevations. It is contraindicated in patients with active liver disease or those who are pregnant. Fluvastatin's efficacy and safety profile make it a valuable option in the management of dyslipidemia, contributing to improved cardiovascular health outcomes when used in conjunction with lifestyle modifications.

Formula: C₂₄H₂₆FNO₄

InChI: InChI=1/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/s2

InChI key: InChIKey=FJLGEFLZQAZZCD-NDDZYTDBNA-N

SMILES: C(=C/[C@@H](C[C@@H](CC(O)=O)O)O)\C1=C(C=2C(N1C(C)C)=CC=CC2)C3=CC=C(F)C=C3

Synonyms:

• (6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate
• (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
• 7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl)-3,5-dihydroxy-6-heptenoic acid
• 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, (3R,5S,6E)-rel-
• Methyl-(±)-(E)-7-[3’-(4’-fluoro-phenyl )-1’-(1’-methylethyl)indol-2’-yl]-3,5- dihydroxy-6- heptenoate
• 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, [R*,S*-(E)]-
• 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, [R*,S*-(E)]-(±)-
• rel-(3R,5S,6E)-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid
• Fluvastatin

Fluvastatin Sodium Salt

CAS: 93957-54-1, 93957-55-2

Formula: C₂₄H₂₅FNNaO₄

Purity: >98.0%(HPLC)(N)

Color and Shape: Light orange to Yellow to Green powder to crystal

Molecular weight: 433.46

Ref: 3B-F0820

Fluvastatin

CAS: 93957-54-1

Formula: C₂₄H₂₆FNO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 411.4659

Ref: IN-DA01E9KC

Fluvastatin

CAS: 93957-54-1

Fluvastatin

Purity: ≥98%

Molecular weight: 411.47g/mol

Ref: 54-BUP11164

Fluvastatin

CAS: 93957-54-1

Fluvastatin (XU-62320) is an HMG-CoA reductase inhibitor used to lower plasma cholesterol levels and prevent cardiovascular disease.

Formula: C₂₄H₂₆FNO₄

Purity: 98.94%

Color and Shape: Solid

Molecular weight: 411.47

Ref: TM-T21405

Fluvastatin

CAS: 93957-54-1

Fluvastatin is a statin that lowers blood cholesterol and triglycerides by inhibiting HMG-CoA reductase, an enzyme that plays a critical role in the synthesis of cholesterol. Fluvastatin has also been shown to reduce the incidence of myocardial infarction, and to reduce atherosclerotic lesions in animal models, reducing the incidence of cardiovascular disease. Fluvastatin also has been shown to inhibit the activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS), which may be related to its anti-inflammatory effects. Furthermore, through lowering blood cholesterol, Fluvastatin also inhibits tubulointerstitial injury and prevents renal damage caused by high concentrations of the lipid.

Formula: C₂₄H₂₆FNO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 411.47 g/mol

Ref: 3D-FF36911