CAS 942183-80-4

SCH772984

Description:

SCH772984 is a small molecule inhibitor primarily known for its selective inhibition of the mitogen-activated protein kinase (MAPK) pathway, specifically targeting the extracellular signal-regulated kinase (ERK) signaling cascade. This compound has garnered attention in cancer research due to its potential therapeutic applications in treating various malignancies characterized by aberrant ERK signaling. SCH772984 exhibits high specificity for ERK1 and ERK2, which are critical components of the MAPK pathway involved in cell proliferation and survival. The compound is typically characterized by its moderate solubility in organic solvents and its stability under physiological conditions. In preclinical studies, SCH772984 has demonstrated efficacy in inhibiting tumor growth in various cancer models, making it a subject of interest for further development in targeted cancer therapies. Its chemical structure and properties facilitate its role as a research tool in understanding ERK-related signaling mechanisms and the development of novel therapeutic strategies.

Synonyms:

• (3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide
• (R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide

(3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide

CAS: 942183-80-4

Formula: C₃₃H₃₃N₉O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 587.6742

Ref: IN-DA00397E

SCH772984

CAS: 942183-80-4

SCH772984

Purity: ≥95%

Molecular weight: 587.67422g/mol

Ref: 54-BISN0139

SCH772984

CAS: 942183-80-4

SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.

Formula: C₃₃H₃₃N₉O₂

Purity: 97.565% - 98.75%

Color and Shape: Solid

Molecular weight: 587.67

Ref: TM-T6066

SCH 772984

CAS: 942183-80-4

Inhibitor of ERK1 and ERK2 serine/threonine kinases

Formula: C₃₃H₃₃N₉O₂

Purity: Min. 95%

Color and Shape: Light (Or Pale) Yellow To Yellow Solid

Molecular weight: 587.67 g/mol

Ref: 3D-FS157995

SCH772984

Controlled Product

CAS: 942183-80-4

Applications SCH772984 is a novel and selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors and has nanomolar cellular potency in tumor cells with mutations in BRAF, NRA5, or KRAS and induces tumor regressions in xenograft models.
References Morris, E. J., et. al.: Cancer Discovery, 3, 742 (2013)

Formula: C₃₃H₃₃N₉O₂

Color and Shape: Neat

Molecular weight: 587.67

Ref: TR-S199940