CAS 94739-29-4

Lemildipine

Description:

Lemildipine is a pharmaceutical compound classified as a calcium channel blocker, primarily used in the treatment of hypertension and certain types of angina. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac cells, leading to vasodilation and reduced blood pressure. Lemildipine is characterized by its long half-life, allowing for once-daily dosing, which enhances patient compliance. The compound exhibits a high degree of selectivity for vascular calcium channels, minimizing effects on cardiac contractility. Its chemical structure includes a dihydropyridine ring, which is essential for its pharmacological activity. Lemildipine is generally well-tolerated, with common side effects including headache, flushing, and peripheral edema. As with other calcium channel blockers, it is contraindicated in patients with certain cardiovascular conditions, such as severe aortic stenosis. Overall, Lemildipine represents an effective option in the management of hypertension, contributing to improved cardiovascular health.

Formula: C₂₀H₂₂Cl₂N₂O₆

InChI: InChI=1S/C20H22Cl2N2O6/c1-9(2)30-19(26)16-13(8-29-20(23)27)24-10(3)14(18(25)28-4)15(16)11-6-5-7-12(21)17(11)22/h5-7,9,15,24H,8H2,1-4H3,(H2,23,27)

InChI key: InChIKey=WTOVRSWDBLIFHU-UHFFFAOYSA-N

SMILES: C(OC(C)C)(=O)C=1C(C(C(OC)=O)=C(C)NC1COC(N)=O)C2=C(Cl)C(Cl)=CC=C2

Synonyms:

• NB 818
• NPK 1886
• 3,5-Pyridinedicarboxylic acid, 2-[[(aminocarbonyl)oxy]methyl]-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-, 5-methyl 3-(1-methylethyl) ester
• Lemildipine
• 3-Isopropyl 5-methyl (±)-4-(2,3-dichlorophenyl)-1,4-dihydro-2-(hydroxymethyl)-6-methyl-3,5-pyridinedicarboxylate, carbamate (ester)

Lavoltidine

CAS: 94739-29-4

Lavoltidine

Purity: ≥98%

Molecular weight: 359.47g/mol

Ref: 54-BUP20551

Lemildipine

Controlled Product

CAS: 94739-29-4

Formula: C₂₀H₂₂Cl₂N₂O₆

Color and Shape: Neat

Molecular weight: 457.305

Ref: TR-L495640

Lemildipine

CAS: 94739-29-4

Lemildipine is a calcium channel blocker drug that blocks voltage-dependent calcium channels in the cell membrane. Lemildipine inhibits the influx of calcium ions into cardiac and smooth muscle cells, which decreases their contractility and reduces blood pressure. It also has been shown to inhibit the release of calcium from the sarcoplasmic reticulum in response to nerve impulses, thereby blocking transmission of these signals to the muscle fibers. This drug has been found to be effective in preventing or treating metabolic disorders such as diabetes. Lemildipine has also been shown to have anti-inflammatory properties and inhibit bowel disease by reducing the amount of water absorbed by the bowel.

Formula: C₂₀H₂₂Cl₂N₂O₆

Purity: Min. 95%

Molecular weight: 457.3 g/mol

Ref: 3D-UDA73929

Lemildipine

CAS: 94739-29-4

Lemildipine is a new blocker of dihydropyridine calcium entry.

Formula: C₂₀H₂₂Cl₂N₂O₆

Color and Shape: Solid

Molecular weight: 457.3

Ref: TM-T15733