CAS 95058-81-4
:Gemcitabine
Description:
Gemcitabine is a nucleoside analog used primarily as an antineoplastic agent in cancer therapy. It is classified as a pyrimidine analog, specifically resembling cytidine, and is known for its ability to inhibit DNA synthesis. The chemical formula of gemcitabine is C9H11F2N3O4, and it features a fluorine atom substitution that enhances its efficacy against certain tumors. Gemcitabine is typically administered intravenously and is effective in treating various cancers, including pancreatic, lung, and bladder cancers. Its mechanism of action involves incorporation into the DNA strand during replication, leading to chain termination and ultimately inducing apoptosis in rapidly dividing cancer cells. The substance is characterized by its relatively low solubility in water, which can affect its formulation and delivery. Additionally, gemcitabine is associated with a range of side effects, including myelosuppression, nausea, and fatigue, necessitating careful monitoring during treatment. Overall, gemcitabine represents a critical component in the arsenal against specific malignancies, showcasing the importance of targeted chemotherapy in oncology.
Formula:C9H11F2N3O4
InChI:InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1
InChI key:InChIKey=SDUQYLNIPVEERB-QPPQHZFASA-N
SMILES:FC1(F)[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C=C2
Synonyms:- Gemcitabine
- Cytidine, 2′-deoxy-2′,2′-difluoro-
- LY 188011
- DDFC
- 2′-Deoxy-2′,2′-difluorocytidine
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Gemcitabine
CAS:Formula:C9H11F2N3O4Purity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:263.20Gemcitabine
CAS:Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis.Formula:C9H11F2N3O4Purity:97.42% - 99.67%Color and Shape:SolidMolecular weight:263.1981Gemcitabine
CAS:Formula:C9H11F2N3O4Purity:≥ 98.0% (dried basis)Color and Shape:White or off-white crystalline powderMolecular weight:263.20Gemcitabine (Standard)
CAS:Gemcitabine (Standard) is a reference standard for research and analysis in studies involving Gemcitabine. Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.Formula:C9H11F2N3O4Molecular weight:263.19812'-DEOXY-2',2'-DIFLUOROCYTIDINE
CAS:Formula:C9H11F2N3O4Purity:98%Color and Shape:SolidMolecular weight:263.1981Ref: IN-DA0038IE
250mg24.00€1g28.00€5g63.00€10g91.00€25g167.00€50g269.00€100g578.00€250g754.00€500g1,318.00€1kg2,402.00€Gemcitabine
CAS:Applications Gemcitabine is used for breast cancer treatment. First-line treatment for locally advanced pancreatic cancer.
References Hamsici, S., et al.: Bioconjugate Chem., (2017); Peng, T., et al.: J. Cell. Biochem., (2017)Formula:C9H11F2N3O4Color and Shape:NeatMolecular weight:263.2Gemcitabine
CAS:4-Amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-oneFormula:C9H11F2N3O4Purity:99%Molecular weight:263.2Gemcitabine base
CAS:Gemcitabine is a prodrug that is converted to 5-fluorouracil (5FU) in the body. It has been shown to inhibit the growth of bladder and pancreatic cancer cells by interfering with the synthesis of DNA. Gemcitabine inhibits DNA replication by binding to the epidermal growth factor receptor, which leads to cell death. Gemcitabine also acts as a competitive inhibitor of deoxycytidine kinase, which prevents the formation of deoxycytidine monophosphate from deoxyuridine monophosphate, preventing DNA replication. In addition, gemcitabine can activate apoptosis in some tumor cells by increasing levels of intracellular free calcium, which leads to activation of enzymes such as phospholipases and proteases that degrade proteins, lipids, and nucleic acids.Formula:C9H11F2N3O4Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:263.2 g/mol
