Gemcitabine base
CAS: 95058-81-4
Ref. 3D-ND04237
| 2g | 110.00 € | ||
| 5g | 186.00 € | ||
| 10g | 304.00 € | ||
| 25g | 568.00 € | ||
| 50g | 864.00 € |
Product Information
- 2-Deoxy-2',2'-difluorocytidine4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one2'-Deoxy-2',2'-difluor o-D-cytidine2',2'-Difluoro-2'-deoxycytidine
Gemcitabine is a prodrug that is converted to 5-fluorouracil (5FU) in the body. It has been shown to inhibit the growth of bladder and pancreatic cancer cells by interfering with the synthesis of DNA. Gemcitabine inhibits DNA replication by binding to the epidermal growth factor receptor, which leads to cell death. Gemcitabine also acts as a competitive inhibitor of deoxycytidine kinase, which prevents the formation of deoxycytidine monophosphate from deoxyuridine monophosphate, preventing DNA replication. In addition, gemcitabine can activate apoptosis in some tumor cells by increasing levels of intracellular free calcium, which leads to activation of enzymes such as phospholipases and proteases that degrade proteins, lipids, and nucleic acids.
Chemical properties
Technical inquiry about: 3D-ND04237 Gemcitabine base
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