CAS 950762-95-5

PCI-34051

Description:

PCI-34051, with the CAS number 950762-95-5, is a small molecule that acts as a selective inhibitor of the protein kinase CK2 (casein kinase 2). This compound is characterized by its ability to interfere with CK2's activity, which plays a crucial role in various cellular processes, including cell proliferation, survival, and apoptosis. The inhibition of CK2 by PCI-34051 has been studied for its potential therapeutic applications, particularly in cancer treatment, as CK2 is often overexpressed in various tumors. The compound is typically characterized by its specific binding affinity to the CK2 enzyme, leading to downstream effects on signaling pathways. Additionally, PCI-34051 has been evaluated in preclinical studies for its efficacy and safety profile, highlighting its potential as a targeted therapy. As with many small molecules, its solubility, stability, and bioavailability are important factors that influence its pharmacological properties and therapeutic potential.

N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide

CAS: 950762-95-5

Formula: C₁₇H₁₆N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 296.3205

Ref: IN-DA00IIQ1

PCI-34051

CAS: 950762-95-5

PCI-34051

Purity: ≥95%

Molecular weight: 296.32g/mol

Ref: 54-BUP10212

N-Hydroxy-1-(4-Methoxybenzyl)-1H-Indole-6-Carboxamide

CAS: 950762-95-5

N-Hydroxy-1-(4-Methoxybenzyl)-1H-Indole-6-Carboxamide

Purity: 98%

Molecular weight: 296.32g/mol

Ref: 54-OR1026173

PCI-34051

CAS: 950762-95-5

Formula: C₁₇H₁₆N₂O₃

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 296.33

Ref: 3B-P3226

PCI-34051

CAS: 950762-95-5

PCI-34051 is an effective and selective HDAC8 inhibitor (IC50: 10 nM).

Formula: C₁₇H₁₆N₂O₃

Purity: 97.219% - 98.29%

Color and Shape: Solid

Molecular weight: 296.32

Ref: TM-T6325

N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide

CAS: 950762-95-5

Purity: 98%

Molecular weight: 296.3259888

Ref: 10-F863965

PCI-34051

Controlled Product

CAS: 950762-95-5

Applications PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.
References Balasubramanian, S. et al.: Leukemia, 22, 1026 (2008); Pipalia, N.H. et al.: Proc. Nat. Acad. Sci. USA, 108, 5620 (2011);

Formula: C₁₇H₁₆N₂O₃

Color and Shape: Neat

Molecular weight: 296.32

Ref: TR-P216600