CAS 950912-80-8

2-Pyrimidinamine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-, hydrochloride (1:2)

Description:

2-Pyrimidinamine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-, hydrochloride (1:2) is a chemical compound characterized by its complex structure, which includes a pyrimidine and imidazole moiety. This substance typically appears as a hydrochloride salt, enhancing its solubility in aqueous solutions. The presence of a cyclohexyl group and a fluorophenyl group contributes to its lipophilicity, potentially influencing its biological activity and pharmacokinetics. The compound may exhibit properties relevant to medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways. Its molecular interactions can be influenced by the functional groups present, which may affect binding affinity to biological targets. As with many compounds in medicinal chemistry, understanding its stability, reactivity, and potential toxicity is crucial for further applications. Safety data and handling precautions should be adhered to, given the presence of nitrogen-containing heterocycles, which can exhibit varied biological activities.

Formula: C₁₉H₂₀FN₅·2HCl

InChI: InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H

InChI key: InChIKey=PSNKGVAXBSAHCH-UHFFFAOYSA-N

SMILES: NC=1N=C(C2=C(N=CN2C3CCCCC3)C4=CC=C(F)C=C4)C=CN1.Cl

Synonyms:

• 2-Pyrimidinamine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-, hydrochloride (1:2)
• 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride
• Pf670462
• Pf 670462
• 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride PF670462
• PF-670462 (hydrochloride)
• PF 670462, >=98%
• 4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride
• 4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine:dihydrochloride
• PF-670462 2HCl
• PF670462/ PF-670462
• 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
• PF 67046
• Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem
• PF670462 dihydrochloride
• 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride
• CS-318
• PF-670462 HCL

PF 670462

CAS: 950912-80-8

Formula: C₁₉H₂₂Cl₂FN₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 410.3159

Ref: IN-DA01CC2S

4-[1-Cyclohexyl-4-(4-Fluorophenyl)-1H-Imidazol-5-Yl]-2-Pyrimidine Hydrochloride

CAS: 950912-80-8

4-[1-Cyclohexyl-4-(4-Fluorophenyl)-1H-Imidazol-5-Yl]-2-Pyrimidine Hydrochloride

Purity: 98%

Molecular weight: 410.32g/mol

Ref: 54-PC108726

PF-670462

CAS: 950912-80-8

PF-670462

Purity: ≥98%

Molecular weight: 410.32g/mol

Ref: 54-BUP05863

PF-670462

CAS: 950912-80-8

PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.

Formula: C₁₉H₂₂Cl₂FN₅

Purity: 99.42% - 99.72%

Color and Shape: Solid

Molecular weight: 410.32

Ref: TM-T3073

PF 670462

CAS: 950912-80-8

Casein kinase (CK1ε and CK1Ύ) inhibitor

Formula: C₁₉H₂₀FN₅·2HCl

Purity: Min. 95%

Molecular weight: 410.32 g/mol

Ref: 3D-FP65129

PF 670462

Controlled Product

CAS: 950912-80-8

Applications PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.
References Bryant, D.D. et al.: Psychopharmacology, 203, 703 (2009); Badura, L. et al.: J. Pharmacol. Exp. Therap., 322, 730 (2007); Sprouse, J. et al.: Psychopharmacology, 210, 569 (2010):

Formula: C₁₉H₂₂Cl₂FN₅

Color and Shape: Neat

Molecular weight: 410.32

Ref: TR-P293960