CAS 951385-68-5

Sildenafil-d8

CAS: 951385-68-5

Formula: C₂₂H₂₂D₈N₆O₄S

Color and Shape: White To Off-White Solid

Molecular weight: 482.63

Ref: 4Z-S-063

Sildenafil-d8 (piperazine-d8)

CAS: 951385-68-5

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 482.63

Ref: 3U-D7300

Sildenafil-d8

CAS: 951385-68-5

Sildenafil-d8 is a deuterated compound of Sildenafil. Sildenafil has a CAS number of 139755-83-2. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction and reduce symptoms of pulmonary arterial hypertension (PAH).

Formula: C₂₂H₂₂D₈N₆O₄S

Color and Shape: Solid

Molecular weight: 482.63

Ref: TM-TMID-0043

Sildenafil-d8

Controlled Product

CAS: 951385-68-5

Applications Sildenafil-d8 is the labeled analogue of Sildenafil (S435000), an orally active selective type 5 cGMP phosphodiesterase inhibitor.
References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996); Goldstein, I., et al.: N. Engl. J. Med., 338, 1397 (1998)

Formula: C₂₂₂H₈H₂₂N₆O₄S

Color and Shape: White To Off-White

Molecular weight: 482.63

Ref: TR-S435003

Sildenafil-d8

Controlled Product

CAS: 951385-68-5

Sildenafil-d8 is a chemical that is used in medicine. It is the 8-deuterated analog of sildenafil. Sildenafil-d8 has been shown to be more potent than sildenafil in inhibiting phosphodiesterase type-5 (PDE5) and to have a longer half-life. This drug has been shown to be effective in the treatment of pulmonary hypertension, which may be due to its ability to relax smooth muscle cells. Sildenafil-d8 can also be used for the treatment of erectile dysfunction, as it inhibits PDE5, an enzyme that degrades cyclic guanosine monophosphate (cGMP). The effects of this drug are dose dependent and are enhanced by the presence of a matrix effect. This drug is extracted from methanol using liquid chromatography with UV detection at 254 nm and mass spectrometry detection at m/z=

Formula: C₂₂H₂₂D₈N₆O₄S

Purity: Min. 95%

Molecular weight: 482.63 g/mol

Ref: 3D-BNB38568