CAS 95153-31-4

Perindoprilat

Description:

Perindoprilat is the active metabolite of the angiotensin-converting enzyme (ACE) inhibitor perindopril, primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to inhibit the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. Perindoprilat is a white to off-white crystalline powder that is soluble in water and exhibits a pKa indicative of its acidic nature. Its molecular structure includes a carboxyl group, which contributes to its pharmacological activity. The compound has a relatively long half-life, allowing for once-daily dosing in clinical settings. Additionally, perindoprilat is known for its favorable side effect profile, making it a commonly prescribed medication. It is important to monitor renal function and potassium levels in patients taking this medication, as it can affect renal hemodynamics and electrolyte balance. Overall, perindoprilat plays a significant role in cardiovascular therapy, demonstrating efficacy in reducing morbidity and mortality associated with heart disease.

Formula: C₁₇H₂₈N₂O₅

InChI: InChI=1S/C17H28N2O5/c1-3-6-12(16(21)22)18-10(2)15(20)19-13-8-5-4-7-11(13)9-14(19)17(23)24/h10-14,18H,3-9H2,1-2H3,(H,21,22)(H,23,24)/t10-,11-,12-,13-,14-/m0/s1

InChI key: InChIKey=ODAIHABQVKJNIY-PEDHHIEDSA-N

SMILES: C([C@@H](N[C@@H](CCC)C(O)=O)C)(=O)N1[C@@]2([C@](C[C@H]1C(O)=O)(CCCC2)[H])[H]

Synonyms:

• (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-Carboxybutyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid
• (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-Carboxybutyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid (non-preferred name)
• (2S-(1(R*(R*)),2a,3ab,7ab))-Octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl)-1H-indole-2-carboxylic Acid
• 1H-Indole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]-1-oxopropyl]octahydro-, (2S,3aS,7aS)-
• 1H-Indole-2-carboxylic acid, 1-[2-[(1-carboxybutyl)amino]-1-oxopropyl]octahydro-, [2S-[1[R*(R*)],2α,3aβ,7aβ]]-
• 95153-31-4
• S 9780
• Perindoprilat
• Perindopril EP IMpurity-B(USP RC B)
• Perindoprilat (Mixture of Diastereomers)
• Perindopril impurity Ⅲ(Perindoprilat)
• [2S-[1[R*(R*)],2α,3aβ,7aβ]]-1-[2-[(1-Carboxybutyl)aMino]-1-
• PERINDOPRILAT HYDRATE
• (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-Carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
• Perindopril Related CoMpound B
• (2S,3AS,7aS)-1-((S)-2-(((S)-1-carboxybutyl)amino)propanoyl)octahydro-1H-indole-2-carboxylic ac
• (2s-(1(r*(r*)),2-alpha,3a-beta,7a-beta))-)
• Perindopril EP IMpurity B
• 1H-Indole-2-carboxylicacid, 1-[(2S)-2-[[(1S)-1-carboxybutyl]aMino]-1-oxopropyl]octahydro-,(2S,3aS,7aS)-
• 1h-indole-2-carboxylicacid,octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl
• Perindoprilat ,95%
• Perindopril Impurity 5
• Diacid form
• oxopropyl]octahydro-1H-indole-2-carboxylic Acid
• Perindopril Related Compound B (10 mg) ((2S,3aS,7aS)-1-{(S)-2-[(S)-1-carboxybutylamino]propanoyl}octahydro-1H-indole-2-carboxylic acid)

Perindoprilat

CAS: 95153-31-4

Formula: C₁₇H₂₈N₂O₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 340.4146

Ref: IN-DA0066D3

Perindoprilat

CAS: 95153-31-4

Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor.

Formula: C₁₇H₂₈N₂O₅

Purity: 99.48%

Color and Shape: Solid

Molecular weight: 340.41

Ref: TM-T1484

Perindopril EP Impurity B (Perindoprilat)

CAS: 95153-31-4

Formula: C₁₇H₂₈N₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 340.42

Ref: 4Z-P-061

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-Carboxybutyl]amino]propanoyl]octahydro-1H-indole-2-carboxylic Acid (Perindoprilat)

CAS: 95153-31-4

Color and Shape: Neat

Ref: 86-MM0926.02

Perindoprilat-d4 (Mixture of Diastereomers)

Controlled Product

CAS: 1356841-18-3, 95153-31-4

Applications Perindoprilat-d4 is the isotope labelled analog of Perindoprilat (P287531); an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive.
References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)

Formula: C₁₇H₂₄D₄N₂O₅

Color and Shape: Neat

Molecular weight: 344.44

Ref: TR-P287534

Perindoprilat

Controlled Product

CAS: 95153-31-4

Stability Hygroscopic
Applications Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive.
References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)

Formula: C₁₇H₂₈N₂O₅

Color and Shape: Off-White

Molecular weight: 340.41

Ref: TR-P287535

Perindoprilat(Mixture of Diastereomers)

Controlled Product

CAS: 95153-31-4

Applications Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive.
References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)

Formula: C₁₇H₂₈N₂O₅

Color and Shape: Neat

Molecular weight: 340.41

Ref: TR-P287531

Perindopril EP Impurity B

CAS: 95153-31-4

Formula: C₁₇H₂₈N₂O₅

Molecular weight: 340.42

Ref: ST-EA-CP-P18002

Perindoprilat t-Butylamine Salt

Controlled Product

CAS: 95153-31-4

Applications Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive.
References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)

Formula: C₂₁H₃₉N₃O₅

Color and Shape: Neat

Molecular weight: 413.55

Ref: TR-P287585