CAS 95233-18-4

Atovaquone

Description:

Atovaquone is an antiprotozoal medication primarily used to treat and prevent Pneumocystis pneumonia in immunocompromised patients, particularly those with HIV/AIDS. It is classified as a hydroxynaphthoquinone and exhibits a mechanism of action that involves the inhibition of mitochondrial electron transport in protozoa, leading to a disruption of their energy metabolism. Atovaquone is characterized by its lipophilic nature, which enhances its absorption and distribution in the body. The substance is typically administered orally and is known for its relatively low toxicity profile. It is often used in combination with other medications to enhance therapeutic efficacy and reduce the risk of resistance. Atovaquone is also notable for its pharmacokinetic properties, including a long half-life, which allows for once-daily dosing. Its chemical structure includes a naphthoquinone core, contributing to its biological activity. Overall, Atovaquone is a crucial agent in the management of specific parasitic infections, particularly in vulnerable populations.

Formula: C₂₂H₁₉ClO₃

InChI: InChI=1/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,26H,5-8H2

InChI key: InChIKey=KUCQYCKVKVOKAY-CTYIDZIINA-N

SMILES: O=C1C(=C(O)C(=O)C=2C1=CC=CC2)[C@H]3CC[C@@H](CC3)C4=CC=C(Cl)C=C4

Synonyms:

• 1,4-Hydroxynaphthoquinone
• 1,4-Naphthalenedione, 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-
• 1,4-Naphthalenedione,2-
• 1,4-Naphthalenedione,2-(4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-, trans
• 2-(4-(4'-Chlorophenyl)Cyclohexyl)-3-Hydroxy-1,4-Naphthoquinone
• 2-(Trans-4-(4-Chlorophenyl)Cyclohexyl)-3-Hydroxy-1,4-Naphthalenedione
• 2-(Trans-4-(4-Chlorophenyl)Cyclohexyl)-3-Hydroxy-1,4-Naphthoquinone
• 2-[4-(4-Chlorophenyl)Cyclohexyl]-3-Hydroxynaphthalene-1,4-Dione
• 2-[Trans-4-(4-Chlorophenyl)Cyclohexyl]-3-Hydroxynaphthalene-1,4-Dione
• 3-[4-(4-Chlorophenyl)Cyclohexyl]-4-Hydroxynaphthalene-1,2-Dione
• 566C80
• Acuvel
• Bw 556C-80
• Bw 566C
• Mepron
• Mepron (antipneumocystic)
• Meprone
• Samtirel
• Wellvone
• 566C
• Atovaquone-D4
• 3-Hydroxy-2-[4β-(4-chlorophenyl)cyclohexan-1α-yl]naphthalene-1,4-dione
• trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
• BW-566C-80

Atovaquone

CAS: 95233-18-4

Formula: C₂₂H₁₉ClO₃

Purity: >98.0%(T)(HPLC)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 366.84

Ref: 3B-A2545

ATOVAQUONE FOR SYSTEM SUITABILITY CRS

CAS: 95233-18-4

ATOVAQUONE FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001573

ATOVAQUONE CRS

CAS: 95233-18-4

ATOVAQUONE CRS

Formula: C₂₂H₁₉ClO₃

Molecular weight: 366.8375

Ref: 41-Y0001572

Atovaquone

CAS: 95233-18-4

Halogenated, sulfonated, nitrated or nitrosated derivatives: chlordecone (iso)

Formula: C₂₂H₁₉ClO₃

Color and Shape: Yellow Powder

Molecular weight: 366.84 g/mol

Ref: 45-1044651

2-(trans-4-(4-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthalenedione

CAS: 95233-18-4

Formula: C₂₂H₁₉ClO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 366.8375

Ref: IN-DA0036UM

2-(Trans-4-(4-Chlorophenyl)Cyclohexyl)-3-Hydroxynaphthalene-1,4-Dione

CAS: 95233-18-4

2-(Trans-4-(4-Chlorophenyl)Cyclohexyl)-3-Hydroxynaphthalene-1,4-Dione

Formula: C₂₂H₁₉ClO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 366.84

Ref: 54-OR1009861

Atovaquone

CAS: 95233-18-4

Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.

Formula: C₂₂H₁₉ClO₃

Purity: 98% - 99.85%

Color and Shape: Yellow To Orange Crystalline Solid

Molecular weight: 366.84

Ref: TM-T1491

Atovaquone

CAS: 95233-18-4

Formula: C₂₂H₁₉ClO₃

Color and Shape: Yellow Solid

Molecular weight: 366.84

Ref: 4Z-A-2710

Atovaquone

CAS: 95233-18-4

Atovaquone

Formula: C₂₂H₁₉ClO₃

Purity: ≥98%

Molecular weight: 366.84

Ref: 54-BUP17165

Atovaquone

CAS: 95233-18-4

Formula: C₂₂H₁₉ClO₃

Purity: ≥ 98.0%

Color and Shape: Yellow to orange powder

Molecular weight: 366.84

Ref: 7W-GP1551

Atovaquone

CAS: 95233-18-4

Formula: C₂₂H₁₉ClO₃

Color and Shape: Neat

Molecular weight: 366.84

Ref: 86-MM3007.00

Didehydroatovaquone isomer

CAS: 95233-18-4

Formula: C₂₂H₁₇ClO₃

Color and Shape: Yellow Solid

Molecular weight: 364.83

Ref: 4Z-A-2713

Atovaquone

CAS: 95233-18-4

Formula: C₂₂H₁₉ClO₃

Molecular weight: 366.84

Ref: ST-EA-CP-A33000

Atovaquone

Controlled Product

CAS: 95233-18-4

Applications Hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport. Antipneumocystic.
References Hudson, A.T., et al.: Drugs Exp. Clin. Res., 17, 427 (1991), Fry, M., et al.: Biochem. Pharmacol., 43, 1545 (1992), El-Sadr, W.M., et al.: N. Engl. J. Med., 339, 1889 (1998),

Formula: C₂₂H₁₉ClO₃

Color and Shape: Neat

Molecular weight: 366.84

Ref: TR-A793500

Atovaquone - Bio-X ™

CAS: 95233-18-4

Atovaquone is an antimicrobial drug that is used for the treatment of Pneumocystis jirovecii pneumonia. This drug is an analog of ubiquinone and has good in vitro activity against Toxoplasma gondii.

Formula: C₂₂H₁₉ClO₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 366.84 g/mol

Ref: 3D-BA164228

Atovaquone

CAS: 95233-18-4

Mitochondrial electron transport inhibitor; anti-parasitic; anti-pneumocystic

Formula: C₂₂H₁₉ClO₃

Purity: Min. 98 Area-%

Color and Shape: Yellow Powder

Molecular weight: 366.84 g/mol

Ref: 3D-FA18025

ATOVAQUONE

CAS: 95233-18-4

Formula: C₂₂H₁₉ClO₃

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 366.84

Ref: 10-F390345

Atovaquone

CAS: 95233-18-4

Color and Shape: Neat

Ref: 61-FOR3007.00