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CAS 95233-18-4

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Atovaquone

Description:
Atovaquone is an antiprotozoal medication primarily used to treat and prevent Pneumocystis pneumonia in immunocompromised patients, particularly those with HIV/AIDS. It is classified as a hydroxynaphthoquinone and exhibits a mechanism of action that involves the inhibition of mitochondrial electron transport in protozoa, leading to a disruption of their energy metabolism. Atovaquone is characterized by its lipophilic nature, which enhances its absorption and distribution in the body. The substance is typically administered orally and is known for its relatively low toxicity profile. It is often used in combination with other medications to enhance therapeutic efficacy and reduce the risk of resistance. Atovaquone is also notable for its pharmacokinetic properties, including a long half-life, which allows for once-daily dosing. Its chemical structure includes a naphthoquinone core, contributing to its biological activity. Overall, Atovaquone is a crucial agent in the management of specific parasitic infections, particularly in vulnerable populations.
Formula:C22H19ClO3
InChI:InChI=1/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,26H,5-8H2
InChI key:InChIKey=KUCQYCKVKVOKAY-CTYIDZIINA-N
SMILES:O=C1C(=C(O)C(=O)C=2C1=CC=CC2)[C@H]3CC[C@@H](CC3)C4=CC=C(Cl)C=C4
Synonyms:
  • 1,4-Hydroxynaphthoquinone
  • 1,4-Naphthalenedione, 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-
  • 1,4-Naphthalenedione,2-
  • 1,4-Naphthalenedione,2-(4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-, trans
  • 2-(4-(4'-Chlorophenyl)Cyclohexyl)-3-Hydroxy-1,4-Naphthoquinone
  • 2-(Trans-4-(4-Chlorophenyl)Cyclohexyl)-3-Hydroxy-1,4-Naphthalenedione
  • 2-(Trans-4-(4-Chlorophenyl)Cyclohexyl)-3-Hydroxy-1,4-Naphthoquinone
  • 2-[4-(4-Chlorophenyl)Cyclohexyl]-3-Hydroxynaphthalene-1,4-Dione
  • 2-[Trans-4-(4-Chlorophenyl)Cyclohexyl]-3-Hydroxynaphthalene-1,4-Dione
  • 3-[4-(4-Chlorophenyl)Cyclohexyl]-4-Hydroxynaphthalene-1,2-Dione
  • See more synonyms
Found 19 products.