CAS 955365-80-7

MK 1775

Description:

MK-1775, also known as AZD1775, is a small molecule inhibitor that primarily targets the checkpoint kinase 1 (CHK1), an important protein involved in the DNA damage response and cell cycle regulation. This compound is characterized by its ability to enhance the sensitivity of cancer cells to DNA-damaging agents, making it a potential therapeutic agent in oncology. MK-1775 is typically used in combination with other chemotherapeutic agents to improve their efficacy, particularly in tumors with specific genetic backgrounds, such as those with p53 mutations. The substance is known for its role in promoting apoptosis in cancer cells by disrupting their ability to repair DNA damage. In terms of its chemical structure, MK-1775 features a unique arrangement of atoms that contributes to its biological activity, although specific structural details are not provided here. As a research compound, MK-1775 has undergone various clinical trials to evaluate its safety and effectiveness in treating different types of cancer.

Formula: C₂₇H₃₂N₈O₂

InChI: InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31)

InChI key: InChIKey=BKWJAKQVGHWELA-UHFFFAOYSA-N

SMILES: C(C=C)N1N(C=2C(C1=O)=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N2)C=5N=C(C(C)(C)O)C=CC5

Synonyms:

• 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one
• 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
• 2-Allyl-1,8-Dimethoxy-9,10-Anthraquinone
• 2-Allyl-1,8-Dimethoxyanthracene-9,10-Dione
• 2-allyl-1-[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
• 3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-
• 9,10-Anthracenedione,1,8-dimethoxy-2-(2-propenyl)
• Adavosertib
• Azd 1775
• Azd1775
• Mk-1775
• Wee 1-1
• MK-1775,MK1775
• MK-1775, >=98%
• 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one
• 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK 1775
• MK-1775, AZD1775,
• 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-
• 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one
• Adavosertib (MK-1775)
• MK-1175
• 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one

1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)pyrazolo[3,4-d]pyrimidin-3-one

CAS: 955365-80-7

Formula: C₂₇H₃₂N₈O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 500.5954

Ref: IN-DA003A4D

2-Allyl-1-(6-(2-Hydroxypropan-2-Yl)Pyridin-2-Yl)-6-((4-(4-Methylpiperazin-1-Yl)Phenyl)Amino)-1H-Pyrazolo[3,4-D]Pyrimidin-3(2H)-One

CAS: 955365-80-7

2-Allyl-1-(6-(2-Hydroxypropan-2-Yl)Pyridin-2-Yl)-6-((4-(4-Methylpiperazin-1-Yl)Phenyl)Amino)-1H-Pyrazolo[3,4-D]Pyrimidin-3(2H)-One

Purity: 98%

Molecular weight: 500.6g/mol

Ref: 54-OR1026225

Adavosertib

CAS: 955365-80-7

Adavosertib

Purity: ≥98%

Molecular weight: 500.6g/mol

Ref: 54-BUP17147

Adavosertib (MK-1775)

CAS: 955365-80-7

Formula: C₂₇H₃₂N₈O₂

Molecular weight: 500.61

Ref: 4Z-A-400001

Adavosertib

CAS: 955365-80-7

Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.

Formula: C₂₇H₃₂N₈O₂

Purity: 98.65% - 99.86%

Color and Shape: Solid

Molecular weight: 500.6

Ref: TM-T2077

MK 1775

Controlled Product

CAS: 955365-80-7

Applications MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.
References Indovina, P., et al.: Cancer Bilo. Ther., 15, 380 (2014);

Formula: C₂₇H₃₂N₈O₂

Color and Shape: Light Yellow

Molecular weight: 500.6

Ref: TR-M424975

MK 1775

CAS: 955365-80-7

Wee1 inhibitor with an IC50 of 5.2 nM

Formula: C₂₇H₃₂N₈O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 500.6 g/mol

Ref: 3D-BM161385

MK 1775-d3

Controlled Product

CAS: 955365-80-7

Formula: C₂₇H₂₉D₃N₈O₂

Color and Shape: Neat

Molecular weight: 503.61

Ref: TR-M424977