CAS 955365-80-7

MK 1775

Description:

MK-1775, also known as AZD1775, is a small molecule inhibitor that primarily targets the checkpoint kinase 1 (CHK1), an important protein involved in the DNA damage response and cell cycle regulation. This compound is characterized by its ability to enhance the sensitivity of cancer cells to DNA-damaging agents, making it a potential therapeutic agent in oncology. MK-1775 is typically used in combination with other chemotherapeutic agents to improve their efficacy, particularly in tumors with specific genetic backgrounds, such as those with p53 mutations. The substance is known for its role in promoting apoptosis in cancer cells by disrupting their ability to repair DNA damage. In terms of its chemical structure, MK-1775 features a unique arrangement of atoms that contributes to its biological activity, although specific structural details are not provided here. As a research compound, MK-1775 has undergone various clinical trials to evaluate its safety and effectiveness in treating different types of cancer.

Formula:C₂₇H₃₂N₈O₂

InChI:InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31)

InChI key:InChIKey=BKWJAKQVGHWELA-UHFFFAOYSA-N

SMILES:C(C=C)N1N(C=2C(C1=O)=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N2)C=5N=C(C(C)(C)O)C=CC5

Synonyms:

1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one
1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
2-Allyl-1,8-Dimethoxy-9,10-Anthraquinone
2-Allyl-1,8-Dimethoxyanthracene-9,10-Dione
2-allyl-1-[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-
9,10-Anthracenedione,1,8-dimethoxy-2-(2-propenyl)
Adavosertib
Azd 1775
Azd1775
Mk-1775
Wee 1-1
MK-1775,MK1775
MK-1775, >=98%
2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one
2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK 1775
MK-1775, AZD1775,
2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-
1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one
Adavosertib (MK-1775)
MK-1175
2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one
See more synonyms

Found 11 products.

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2-Allyl-1-(6-(2-Hydroxypropan-2-Yl)Pyridin-2-Yl)-6-((4-(4-Methylpiperazin-1-Yl)Phenyl)Amino)-1H-Pyrazolo[3,4-D]Pyrimidin-3(2H)-One
CAS:
- 955365-80-7
2-Allyl-1-(6-(2-Hydroxypropan-2-Yl)Pyridin-2-Yl)-6-((4-(4-Methylpiperazin-1-Yl)Phenyl)Amino)-1H-Pyrazolo[3,4-D]Pyrimidin-3(2H)-One
Formula:C₂₇H₃₂N₈O₂
Purity:98%
Molecular weight:500.6
Ref: 54-OR1026225
25mg
91.00€
VAT not included
50mg
109.00€
VAT not included
100mg
144.00€
VAT not included
250mg
201.00€
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1g
450.00€
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5g
1,321.00€
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Adavosertib
CAS:
- 955365-80-7
Adavosertib
Formula:C₂₇H₃₂N₈O₂
Purity:99.5%
Molecular weight:500.6
Ref: 54-BUP17147
5mg
64.00€
VAT not included
10mg
98.00€
VAT not included
25mg
120.00€
VAT not included
50mg
141.00€
VAT not included
100mg
179.00€
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200mg
248.00€
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Adavosertib (MK-1775)
CAS:
- 955365-80-7
Formula:C₂₇H₃₂N₈O₂
Molecular weight:500.61
Ref: 4Z-A-400001
5mg
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100mg
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10mg
436.00€
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25mg
623.00€
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50mg
810.00€
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MK 1775
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 955365-80-7
Applications MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.
References Indovina, P., et al.: Cancer Bilo. Ther., 15, 380 (2014);
Formula:C₂₇H₃₂N₈O₂
Color and Shape:Neat
Molecular weight:500.6
Ref: TR-M424975
5mg
100.00€
VAT not included
10mg
137.00€
VAT not included
50mg
461.00€
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2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one
CAS:
- 955365-80-7
Formula:C₂₇H₃₂N₈O₂
Purity:98%
Molecular weight:500.6
Ref: IN-DG238532
+ Info
Adavosertib
CAS:
- 955365-80-7
Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.
Formula:C₂₇H₃₂N₈O₂
Purity:98.65% - 99.86%
Color and Shape:Solid
Molecular weight:500.6
Ref: TM-T2077
+ Info
MK 1775
CAS:
- 955365-80-7
Wee1 inhibitor with an IC50 of 5.2 nM
Formula:C₂₇H₃₂N₈O₂
Purity:Min. 95%
Color and Shape:Powder
Molecular weight:500.6 g/mol
Ref: 3D-BM161385
10mg
244.00€
VAT not included
50mg
716.00€
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Adavosertib
CAS:
- 955365-80-7
Formula:C₂₇H₃₂N₈O₂
Molecular weight:500.6
Ref: BE-RMCK020066
1mg
48.00€
VAT not included
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2-Allyl-1-[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
CAS:
- 955365-80-7
Purity:98%
Molecular weight:500.6069946
Ref: 10-F862517
1g
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5g
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50mg
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100mg
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250mg
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25mg
58.00€
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MK 1775-d3
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 955365-80-7
Formula:C₂₇H₂₉D₃N₈O₂
Color and Shape:Neat
Molecular weight:503.61
Ref: TR-M424977
100mg
17,982.00€
VAT not included
+ Info
1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)pyrazolo[3,4-d]pyrimidin-3-one
CAS:
- 955365-80-7
Formula:C₂₇H₃₂N₈O₂
Purity:98%
Color and Shape:Solid
Molecular weight:500.5954
Ref: IN-DA003A4D
5g
Discontinued
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10g
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25g
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5mg
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10mg
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25mg
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50mg
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100mg
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250mg
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1g
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Discontinued product

CAS 955365-80-7

MK 1775

2-Allyl-1-(6-(2-Hydroxypropan-2-Yl)Pyridin-2-Yl)-6-((4-(4-Methylpiperazin-1-Yl)Phenyl)Amino)-1H-Pyrazolo[3,4-D]Pyrimidin-3(2H)-One

Ref: 54-OR1026225

Adavosertib

Ref: 54-BUP17147

Adavosertib (MK-1775)

Ref: 4Z-A-400001

MK 1775

Ref: TR-M424975

2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one

Ref: IN-DG238532

Adavosertib

Ref: TM-T2077

MK 1775

Ref: 3D-BM161385

Adavosertib

Ref: BE-RMCK020066

2-Allyl-1-[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

Ref: 10-F862517

MK 1775-d3

Ref: TR-M424977

1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)pyrazolo[3,4-d]pyrimidin-3-one

Ref: IN-DA003A4D