CAS 956104-40-8
:Apalutamide
Description:
Apalutamide is a synthetic organic compound classified as a non-steroidal androgen receptor inhibitor, primarily used in the treatment of prostate cancer. It functions by binding to androgen receptors, thereby blocking the action of androgens like testosterone, which can promote the growth of prostate cancer cells. The molecular formula of apalutamide is C19H22F2N4O2, and it has a relatively complex structure featuring multiple functional groups, including a pyrimidine ring. Apalutamide is typically administered orally and has been shown to improve progression-free survival in patients with non-metastatic castration-resistant prostate cancer. Its pharmacokinetics indicate good oral bioavailability, with metabolism primarily occurring in the liver. Common side effects may include fatigue, rash, and hypertension, reflecting its systemic effects. As a targeted therapy, apalutamide represents a significant advancement in the management of prostate cancer, offering a more focused approach compared to traditional chemotherapy.
Formula:C21H15F4N5O2S
InChI:InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)
InChI key:InChIKey=HJBWBFZLDZWPHF-UHFFFAOYSA-N
SMILES:O=C1C2(N(C(=S)N1C=3C=C(C(F)(F)F)C(C#N)=NC3)C4=CC(F)=C(C(NC)=O)C=C4)CCC2
Synonyms:- 4-[7-[6-Cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide
- 4-[7-[6-Cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide
- Apalutamide
- Ar 509
- Benzamide, 4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methyl-
- Erleada
- A 52
- ARN 509
- ARN-509
- ARN 509
- AR509 100G
- AR509
- ARN509, Apalutamide
- 4-[7-[6-Cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide ARN-509
- Copanlisib Dihydrochloride
- 4-(7-(4-Cyano-3-(trifluoromethyl)phenyl)-8-hydroxy-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-f
- 4-(7-(6-cyano-5-(trifluoroMethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspirooctan-5-yl)-2-fluoro-N-MethylbenzaMide
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Found 11 products.
4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
CAS:4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamidePurity:98%Molecular weight:477.44g/molApalutamide-13C-d3
CAS:Formula:C2013CH12D3F4N5O2SColor and Shape:White To Off-White SolidMolecular weight:481.45Apalutamide
CAS:<p>Apalutamide (ARN-509) is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.</p>Formula:C21H15F4N5O2SPurity:99.03% - 99.91%Color and Shape:SolidMolecular weight:477.43Apalutamide
CAS:Controlled Product<p>Applications Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.<br>References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)<br></p>Formula:C21H15F4N5O2SColor and Shape:White To Off-WhiteMolecular weight:477.4347ARN 509
CAS:<p>A potent antagonist of androgen receptor with IC50 value of 16 nM. Binds androgen receptors, thereby inhibiting nuclear translocation, DNA binding and transcriptional activation. Has therapeutic applications in non-metastatic, castration-resistant prostate cancer.</p>Formula:C21H15F4N5O2SPurity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:477.44 g/molApalutamide-d7
CAS:Controlled ProductFormula:C21H8D7F4N5O2SColor and Shape:NeatMolecular weight:484.48
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