CAS 956104-40-8

Apalutamide

Description:

Apalutamide is a synthetic organic compound classified as a non-steroidal androgen receptor inhibitor, primarily used in the treatment of prostate cancer. It functions by binding to androgen receptors, thereby blocking the action of androgens like testosterone, which can promote the growth of prostate cancer cells. The molecular formula of apalutamide is C19H22F2N4O2, and it has a relatively complex structure featuring multiple functional groups, including a pyrimidine ring. Apalutamide is typically administered orally and has been shown to improve progression-free survival in patients with non-metastatic castration-resistant prostate cancer. Its pharmacokinetics indicate good oral bioavailability, with metabolism primarily occurring in the liver. Common side effects may include fatigue, rash, and hypertension, reflecting its systemic effects. As a targeted therapy, apalutamide represents a significant advancement in the management of prostate cancer, offering a more focused approach compared to traditional chemotherapy.

Formula: C₂₁H₁₅F₄N₅O₂S

InChI: InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)

InChI key: InChIKey=HJBWBFZLDZWPHF-UHFFFAOYSA-N

SMILES: O=C1C2(N(C(=S)N1C=3C=C(C(F)(F)F)C(C#N)=NC3)C4=CC(F)=C(C(NC)=O)C=C4)CCC2

Synonyms:

• 4-[7-[6-Cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide
• 4-[7-[6-Cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide
• Apalutamide
• Ar 509
• Benzamide, 4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methyl-
• Erleada
• A 52
• ARN 509
• ARN-509
• ARN 509
• AR509 100G
• AR509
• ARN509, Apalutamide
• 4-[7-[6-Cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide ARN-509
• Copanlisib Dihydrochloride
• 4-(7-(4-Cyano-3-(trifluoromethyl)phenyl)-8-hydroxy-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-f
• 4-(7-(6-cyano-5-(trifluoroMethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspirooctan-5-yl)-2-fluoro-N-MethylbenzaMide

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide

CAS: 956104-40-8

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide

Formula: C₂₁H₁₅F₄N₅O₂S

Purity: 98%

Molecular weight: 477.44

Ref: 54-PC109070

ARN-509

CAS: 956104-40-8

Formula: C₂₁H₁₅F₄N₅O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 477.4347

Ref: IN-DA00IJ8N

Apalutamide

CAS: 956104-40-8

Apalutamide

Formula: C₂₁H₁₅F₄N₅O₂S

Purity: ≥98%

Molecular weight: 477.43

Ref: 54-BUP13002

Apalutamide

CAS: 956104-40-8

Formula: C₂₁H₁₅F₄N₅O₂S

Color and Shape: Off-White Solid

Molecular weight: 477.44

Ref: 4Z-A-284001

Apalutamide-13C-d3

CAS: 956104-40-8

Formula: C₂₀₁₃CH₁₂D₃F₄N₅O₂S

Color and Shape: White To Off-White Solid

Molecular weight: 481.45

Ref: 4Z-A-284002

Apalutamide

CAS: 956104-40-8

Color and Shape: Neat

Ref: 86-MM3993.00

Apalutamide

CAS: 956104-40-8

Apalutamide (ARN-509) is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.

Formula: C₂₁H₁₅F₄N₅O₂S

Purity: 99.03% - 99.91%

Color and Shape: Solid

Molecular weight: 477.43

Ref: TM-T2339

Apalutamide

Controlled Product

CAS: 956104-40-8

Applications Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.
References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)

Formula: C₂₁H₁₅F₄N₅O₂S

Color and Shape: Neat

Molecular weight: 477.4347

Ref: TR-A726120

ARN 509

CAS: 956104-40-8

A potent antagonist of androgen receptor with IC50 value of 16 nM. Binds androgen receptors, thereby inhibiting nuclear translocation, DNA binding and transcriptional activation. Has therapeutic applications in non-metastatic, castration-resistant prostate cancer.

Formula: C₂₁H₁₅F₄N₅O₂S

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 477.44 g/mol

Ref: 3D-FA64943

Apalutamide

CAS: 956104-40-8

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide

Formula: C₂₁H₁₅F₄N₅O₂S

Purity: 98%

Molecular weight: 477.43

Ref: IN-DG290987

Apalutamide

CAS: 956104-40-8

Purity: 98%

Molecular weight: 477.4400024

Ref: 10-F857109

Apalutamide

CAS: 956104-40-8

Formula: C₂₁H₁₅F₄N₅O₂S

Molecular weight: 477.44

Ref: ST-EA-CP-A92000

Apalutamide-d7

Controlled Product

CAS: 956104-40-8

Formula: C₂₁H₈D₇F₄N₅O₂S

Color and Shape: Neat

Molecular weight: 484.48

Ref: TR-A726121