CAS 95635-55-5

Ranolazine

Description:

Ranolazine is an antianginal medication primarily used to treat chronic stable angina pectoris. It functions by inhibiting the late sodium current in cardiac myocytes, which helps to reduce intracellular sodium and calcium overload, ultimately improving myocardial oxygen efficiency. The chemical formula of ranolazine is C24H33N3O4S, and it has a molecular weight of approximately 427.6 g/mol. This compound is characterized by its unique structure, which includes a piperazine ring and a thiazole moiety. Ranolazine is typically administered orally and is known for its relatively low side effect profile compared to traditional antianginal therapies. It does not significantly affect heart rate or blood pressure, making it suitable for patients who may not tolerate other medications. Additionally, ranolazine has been shown to have metabolic effects, potentially improving glucose metabolism in diabetic patients. Its pharmacokinetics involve extensive hepatic metabolism, primarily via the cytochrome P450 system, and it has a moderate half-life, necessitating careful consideration of dosing regimens.

Formula: C₂₄H₃₃N₃O₄

InChI: InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)

InChI key: InChIKey=XKLMZUWKNUAPSZ-UHFFFAOYSA-N

SMILES: O(CC(CN1CCN(CC(NC2=C(C)C=CC=C2C)=O)CC1)O)C3=C(OC)C=CC=C3

Synonyms:

• (±)-N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propry]-1-piperazine acetamide
• 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-
• 1-[3-(2-Methoxyphenoxy)-2-Hydroxypropyl]-4-[(2,6-Dimethylphenyl)Aminocarbonylmethy]Piperazine
• 4-(Pyrimidin-2-ylmethyl)-7-(4-(trifluoromethyl)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one
• Cvt 303
• N-(2,6-Dimethylphenyl)-2-[4-[2-Hydroxy-3-(2-Methoxyphenoxy)Propyl]Piperazin-1-Yl]Acetamide
• N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide
• Ranexa
• Renexa
• Rs 43285-003
• Ranolazine

Ranolazine Dihydrochloride

CAS: 95635-55-5, 95635-56-6

Formula: C₂₄H₃₃N₃O₄·2HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 500.46

Ref: 3B-R0112

Ranolazine

CAS: 95635-55-5

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₄H₃₃N₃O₄

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 427.24711

Ref: 45-1598744

N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide

CAS: 95635-55-5

Formula: C₂₄H₃₃N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 427.5365

Ref: IN-DA00H8QM

Ranolazine-d5

CAS: 95635-55-5

Formula: C₂₄H₂₈D₅N₃O₄

Color and Shape: White To Off-White Solid

Molecular weight: 432.58

Ref: 4Z-R-172

Ranolazine

CAS: 95635-55-5

Ranolazine

Purity: ≥98%

Molecular weight: 427.54g/mol

Ref: 54-BUP16070

Ranolazine

CAS: 95635-55-5

Ranolazine

Purity: 98%

Molecular weight: 427.54g/mol

Ref: 54-OR1030242

Ranolazine

CAS: 95635-55-5

Formula: C₂₄H₃₃N₃O₄

Color and Shape: White To Off-White Solid

Molecular weight: 427.55

Ref: 4Z-R-171

Ranolazine

CAS: 95635-55-5

Formula: C₂₄H₃₃N₃O₄

Molecular weight: 427.54

Ref: 7W-GP0528

Ranolazine

CAS: 95635-55-5

Formula: C₂₄H₃₃N₃O₄

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 427.55

Ref: 3B-R0247

Ranolazine

Controlled Product

CAS: 95635-55-5

Formula: C₂₄H₃₃N₃O₄

Color and Shape: Neat

Molecular weight: 427.54

Ref: 86-MM3496.00

Ranolazine Impurity 14

CAS: 95635-55-5

Formula: C₃₄H₄₅N₃O₇

Molecular weight: 607.75

Ref: 4Z-R-1724

Ranolazine

CAS: 95635-55-5

Ranolazine (RS 43285-003) inhibits calcium uptake, treats chronic angina by targeting sodium/calcium channels to modulate intracellular sodium.

Formula: C₂₄H₃₃N₃O₄

Purity: 98.13%

Color and Shape: White Solid

Molecular weight: 427.54

Ref: TM-T6633

Ranolazine

Controlled Product

CAS: 95635-55-5

Formula: C₂₄H₃₃N₃O₄

Color and Shape: Neat

Molecular weight: 427.54

Ref: TR-R122500

Ranolazine

CAS: 95635-55-5

Anti-anginal; anti-arrhythmic; anti-ischemic; pFOX inhibitor

Formula: C₂₄H₃₃N₃O₄

Purity: Min. 95%

Color and Shape: White Solid

Molecular weight: 427.54 g/mol

Ref: 3D-FD61499

Ranolazine - Bio-X ™

CAS: 95635-55-5

Ranolazine is a group P2 drug that reverses the pathogenic mechanism of myocardial infarction. It is used to treat chronic angina. It decreases myocardial wall tension and improves coronary blood flow. It inhibits the ryanodine receptor, which is responsible for regulating the release of intracellular calcium in cardiac and skeletal muscle cells. Furthermore, it is also effective at preventing atrial fibrillation and has been studied as monotherapy as well as in combination with other medications used to treat irregular heartbeat.

Formula: C₂₄H₃₃N₃O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 427.54 g/mol

Ref: 3D-BD164322

N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide

CAS: 95635-55-5

Formula: C₂₄H₃₃N₃O₄

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 427.545

Ref: 10-F079440