CAS 95635-56-6

Ranolazine hydrochloride

Description:

Ranolazine hydrochloride is a pharmaceutical compound primarily used in the management of chronic angina and is classified as an antianginal agent. It functions by inhibiting the late sodium current in cardiac myocytes, which helps to improve myocardial oxygen consumption and reduce anginal episodes. The substance is a white to off-white crystalline powder, soluble in water and methanol, but less soluble in organic solvents like ethanol and chloroform. Its chemical formula is C24H33N3O4S·HCl, indicating the presence of a hydrochloride salt, which enhances its solubility and stability. Ranolazine is typically administered orally and has a relatively long half-life, allowing for twice-daily dosing. It is important to note that ranolazine may interact with other medications, particularly those metabolized by the liver, and can have side effects such as dizziness, nausea, and constipation. As with any medication, it should be used under the guidance of a healthcare professional, considering individual patient factors and potential drug interactions.

Formula: C₂₄H₃₃N₃O₄·2ClH

InChI: InChI=1S/C24H33N3O4.2ClH/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3;;/h4-10,20,28H,11-17H2,1-3H3,(H,25,29);2*1H

InChI key: InChIKey=RJNSNFZXAZXOFX-UHFFFAOYSA-N

SMILES: O(CC(CN1CCN(CC(NC2=C(C)C=CC=C2C)=O)CC1)O)C3=C(OC)C=CC=C3.Cl

Synonyms:

• (+/-)-4-[2-Hydroxy-3-(O-Methoxyphenoxy)Propyl]-1-Piperazineaceto-2',6'-Xylidide Dihydrochloride
• (+/-)-N-(2,6-Dimethylphenyl)-4-[2-Hydroxy-3-(2-Methoxyphenoxy)Propyl]-1-Piperazineacetamide Dihydrochloride
• (±)-N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide
• (±)-Rs 43285-193
• 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-, dihydrochloride
• 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-, hydrochloride (1:2)
• N-(2,6-Dimethylphenyl)-2-[4-[2-Hydroxy-3-(2-Methoxyphenoxy)Propyl]Piperazin-1-Yl]Acetamide Dihydrochloride
• Ranolazine Di Hcl
• Ranolazine DiHCI
• Ranolazine Dihydrochloride
• Ranolazine and salt
• Ranolazine hydrochloride
• Ranolazine2Hcl

Ranolazine Dihydrochloride

CAS: 95635-55-5, 95635-56-6

Formula: C₂₄H₃₃N₃O₄·2HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 500.46

Ref: 3B-R0112

1-​Piperazineacetamide, N-​(2,​6-​dimethylphenyl)​-​4-​[2-​hydroxy-​3-​(2-​methoxyphenoxy)​propyl]​-​, hydrochloride (1:2)

CAS: 95635-56-6

Formula: C₂₄H₃₄ClN₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 463.9975

Ref: IN-DA00H8QL

Ranolazine dihydrochloride

CAS: 95635-56-6

Ranolazine 2HCl, an antianginal, treats arrhythmia by inhibiting sodium current without changing blood pressure or heart rate.

Formula: C₂₄H₃₅Cl₂N₃O₄

Purity: 99.30% - >99.99%

Color and Shape: White Crystalline Powder

Molecular weight: 500.46

Ref: TM-T0207

Ranolazine Dihydrochloride

CAS: 95635-56-6

Ranolazine Dihydrochloride

Purity: 99%

Molecular weight: 500.46g/mol

Ref: 54-OR1014887

Ranolazine dihydrochloride

CAS: 95635-56-6

Formula: C₂₄H₃₃N₃O₄·2HCl

Molecular weight: 500.46

Ref: 7W-GP5916

Ranolazine dihydrochloride

CAS: 95635-56-6

Ranolazine dihydrochloride

Purity: ≥98%

Molecular weight: 500.46g/mol

Ref: 54-BUP15060

Ranolazine Dihydrochloride

CAS: 95635-56-6

Stability Hygroscopic
Applications Ranolazine Dihydrochloride is an anti-ischemic agent which modulates myocardial metabolism. Antianginal.
References Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002)

Formula: C₂₄H₃₅Cl₂N₃O₄

Color and Shape: Neat

Molecular weight: 500.46

Ref: TR-R122505

N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide dihydrochloride

CAS: 95635-56-6

Purity: 98%

Molecular weight: 500.4599915

Ref: 10-F863805