CAS 957116-20-0

(8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride

Description:

The chemical substance with the name "(8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride" and CAS number "957116-20-0" is a complex organic compound characterized by its unique spirocyclic structure, which includes multiple fused rings and a diazaspiro framework. This compound features a difluorophenyl group, contributing to its potential biological activity and lipophilicity. The presence of an acetamide functional group suggests possible interactions with biological targets, making it of interest in medicinal chemistry. The hydrochloride salt form indicates enhanced solubility in aqueous environments, which is beneficial for pharmacological applications. Its stereochemistry, particularly the (8R) and (2R) configurations, is crucial for its biological activity, as stereoisomers can exhibit significantly different properties. Overall, this compound's intricate structure and functional groups suggest potential utility in drug development, particularly in targeting specific biological pathways.

Formula: C₃₁H₂₉F₂N₅O₃·HCl

InChI: InChI=1S/C31H29F2N5O3.ClH/c32-21-10-19(11-22(33)13-21)25-16-35-31(7-1-2-8-31)29(41)38(25)17-26(39)36-23-6-5-18-14-30(15-20(18)12-23)24-4-3-9-34-27(24)37-28(30)40;/h3-6,9-13,25,35H,1-2,7-8,14-17H2,(H,36,39)(H,34,37,40);1H/t25-,30+;/m0./s1

InChI key: VWKNXYACOMQRBX-KZCKSIIFSA-N

SMILES: C1CCC2(C1)C(=O)N([C@@H](CN2)C3=CC(=CC(=C3)F)F)CC(=O)NC4=CC5=C(C[C@@]6(C5)C7=C(NC6=O)N=CC=C7)C=C4.Cl

Synonyms:

• MK-3207 HCl salt
• MK 3207 hydrochloride
• 6,9-Diazaspiro[4.5]decane-9-acetamide, 8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, hydrochloride
• (8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride USP/EP/BP
• MK3207 MK-3207 hydrochloride HCL
• MK3207 HCl
• MK3207 HYDROCHLORIDE;MK 3207 HYDROCHLORIDE;MK-3207
• 2-((R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide hydrochloride
• CS-549
• (8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride

MK-3207 (Hydrochloride)

CAS: 957116-20-0

MK-3207 (Hydrochloride)

Formula: C₃₁H₃₀ClF₂N₅O₃

Purity: 98%

Molecular weight: 594.05

Ref: 54-PC1027869

MK-3207 Hydrochloride

CAS: 957116-20-0

MK-3207 Hydrochloride (MK-3207 HCl) is a potent CGRP receptor antagonist with IC₅₀ and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.

Formula: C₃₁H₃₀ClF₂N₅O₃

Purity: 98.19%

Color and Shape: Yellow Solid

Molecular weight: 594.051

Ref: TM-T6590

MK-3207 Hydrochloride

CAS: 957116-20-0

Formula: C₃₁H₃₀ClF₂N₅O₃

Purity: 98%

Molecular weight: 594.0514

Ref: IN-DA005YDF

MK-3207 Hydrochloride

CAS: 957116-20-0

MK-3207 Hydrochloride is a potent and selective inhibitor of the voltage-gated potassium channel Kv1.3. It blocks potassium ion channels, which prevents the activation of neurons, resulting in the suppression of pain. MK-3207 Hydrochloride has been shown to be effective in preclinical studies for treating neuropathic pain, chronic pain, and cancer pain. This compound may also be used as research tool for studying protein interactions, ion channels and cell biology.br>br>

Formula: C₃₁H₃₀ClF₂N₅O₃

Purity: Min. 95%

Molecular weight: 594.05 g/mol

Ref: 3D-HNB11620