CAS 95734-82-0
:Nedaplatin
Description:
Nedaplatin is a platinum-based chemotherapeutic agent, primarily used in the treatment of various cancers, including lung and head and neck cancers. It is a second-generation platinum compound, designed to overcome some of the limitations associated with cisplatin, such as nephrotoxicity and gastrointestinal side effects. Nedaplatin exhibits antitumor activity by forming DNA cross-links, which inhibit DNA replication and transcription, ultimately leading to cancer cell death. Its chemical structure includes a platinum atom coordinated to various ligands, which enhances its solubility and bioavailability compared to its predecessors. Nedaplatin is typically administered intravenously and has been shown to have a different side effect profile, often resulting in less severe nausea and vomiting. However, like other platinum compounds, it can still cause myelosuppression and peripheral neuropathy. Ongoing research continues to explore its efficacy in combination with other therapeutic agents and its potential in treating resistant cancer types. Overall, nedaplatin represents an important option in the arsenal of chemotherapeutic agents for oncologists.
Formula:C2H8N2O3Pt
InChI:InChI=1S/C2H3O3.2H3N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H3;/q-1;;;+2/p-1
InChI key:InChIKey=GYAVMUDJCHAASE-UHFFFAOYSA-M
SMILES:[NH3][Pt+2]1([NH3])[O-]C(=O)C[O-]1
Synonyms:- (Glycolato-O,O')Diammineplatinum(Ii)
- (SP-4-3)-Diammine[2-(hydroxy-κO)acetato(2-)-κO]platinum
- 254-S
- Acetic acid, hydroxy-, platinum complex
- Aqupla
- Cis-Diammine(Glycolato)Platinum(Ii)
- Diammine(Glycolato)Platinum(Ii) Nedaplatin Nsc 375101D
- NSC 375101
- Nedaplait
- O(Sup 2))- Diammine(Hydroxyacetato(2-)-O(Sup 1 (Sp-4-3)-Platinu (Glycolato-O,O')Diammineplatinum(Ii) 254-S Cis-
- O(Sup2))-Diammine(Hydroxyacetato(2-)-O(Sup1(Sp-4-3)-Platinu
- Platinum(2+) Azanide - Hydroxyacetic Acid (1:2:1)
- Platinum, diammine[(hydroxy-κO)acetato(2-)-κO]-, (SP-4-3)-
- Platinum, diammine[2-(hydroxy-κO)acetato(2-)-κO]-, (SP-4-3)-
- Platinum, diammine[hydroxyacetato(2-)-O<sup>1</sup>,O<sup>2</sup>]-, (SP-4-3)-
- S 254
- diamino[(hydroxy-kappaO)acetato(2-)-kappaO]platinum
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Found 9 products.
Nedaplatin
CAS:(SP-4-3)-Diammine[2-(hydroxy-κO)acetato(2-)-κO]platinumFormula:C2H8N2O3PtPurity:98%Molecular weight:303.17Nedaplatin
CAS:Nedaplatin, a cisplatin derivative, induces tumor DNA damage (IC50: 94 μM) through platinum-DNA cross-links, causing apoptosis.Formula:C2H8N2O3PtPurity:99.88% - >99.99%Color and Shape:SolidMolecular weight:303.17Platinum, diammine[2-(hydroxy-κO)acetato(2-)-κO]-, (SP-4-3)-
CAS:Formula:C2H6N2O3PtPurity:98%Color and Shape:SolidMolecular weight:301.1586Nedaplatin
CAS:Nedaplatin is a platinum-based anti-cancer drug that has been reported to have significant cytotoxicity against human osteosarcoma cells. It is used in chemotherapy as a radiosensitizer. Nedaplatin can be used to treat cancers that are unresponsive to cisplatin, such as non-small cell lung cancer, ovarian cancer, and breast cancer. Nedaplatin is administered intravenously and has acute toxicities that include nephrotoxicity, neurotoxicity, and ototoxicity. This drug is an anti-cancer compound that has been shown to inhibit the proliferation of cells by binding with DNA at the site of DNA damage and inhibiting DNA repair. The polymer coating on nedaplatin reduces its toxicity by preventing it from entering cells through passive diffusion.
Formula:C2H2O3Pt·2H3NPurity:Min. 95%Color and Shape:PowderMolecular weight:303.18 g/mol
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