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CAS 95734-82-0

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Nedaplatin

Description:
Nedaplatin is a platinum-based chemotherapeutic agent, primarily used in the treatment of various cancers, including lung and head and neck cancers. It is a second-generation platinum compound, designed to overcome some of the limitations associated with cisplatin, such as nephrotoxicity and gastrointestinal side effects. Nedaplatin exhibits antitumor activity by forming DNA cross-links, which inhibit DNA replication and transcription, ultimately leading to cancer cell death. Its chemical structure includes a platinum atom coordinated to various ligands, which enhances its solubility and bioavailability compared to its predecessors. Nedaplatin is typically administered intravenously and has been shown to have a different side effect profile, often resulting in less severe nausea and vomiting. However, like other platinum compounds, it can still cause myelosuppression and peripheral neuropathy. Ongoing research continues to explore its efficacy in combination with other therapeutic agents and its potential in treating resistant cancer types. Overall, nedaplatin represents an important option in the arsenal of chemotherapeutic agents for oncologists.
Formula:C2H8N2O3Pt
InChI:InChI=1S/C2H3O3.2H3N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H3;/q-1;;;+2/p-1
InChI key:InChIKey=GYAVMUDJCHAASE-UHFFFAOYSA-M
SMILES:[NH3][Pt+2]1([NH3])[O-]C(=O)C[O-]1
Synonyms:
  • (Glycolato-O,O')Diammineplatinum(Ii)
  • (SP-4-3)-Diammine[2-(hydroxy-κO)acetato(2-)-κO]platinum
  • 254-S
  • Acetic acid, hydroxy-, platinum complex
  • Aqupla
  • Cis-Diammine(Glycolato)Platinum(Ii)
  • Diammine(Glycolato)Platinum(Ii) Nedaplatin Nsc 375101D
  • NSC 375101
  • Nedaplait
  • O(Sup 2))- Diammine(Hydroxyacetato(2-)-O(Sup 1 (Sp-4-3)-Platinu (Glycolato-O,O')Diammineplatinum(Ii) 254-S Cis-
  • See more synonyms
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