CAS 959119-22-3

Clarithromycin-N-methyl-13C, d3

Description:

Clarithromycin-N-methyl-13C, d3 is a stable isotope-labeled derivative of clarithromycin, an antibiotic belonging to the macrolide class. This compound is characterized by the incorporation of three deuterium atoms (d3) and a carbon-13 isotope (13C) into its molecular structure, which allows for enhanced tracking and analysis in various biochemical studies. The presence of these isotopes does not significantly alter the pharmacological properties of clarithromycin, which is primarily used to treat bacterial infections by inhibiting protein synthesis in susceptible organisms. The labeling with deuterium and carbon-13 is particularly useful in pharmacokinetic studies, metabolic profiling, and tracer studies, as it enables researchers to differentiate between the labeled and unlabeled forms of the drug in biological systems. Clarithromycin itself is known for its broad-spectrum activity against various Gram-positive and some Gram-negative bacteria, as well as atypical pathogens. The specific characteristics of the labeled compound, including its molecular weight and spectral properties, can be determined through techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy.

Formula: C₃₈H₆₉NO₁₃

InChI: InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1/i11D3

InChI key: AGOYDEPGAOXOCK-AOAQTVJMSA-N

SMILES: [2H]C([2H])([2H])N(C)[C@H]1C[C@H](O[C@H]([C@@H]1O)O[C@@H]2[C@H]([C@@H]([C@H](C(=O)O[C@@H]([C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]2(C)OC)C)C)O)(C)O)CC)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)OC)C)C

Synonyms:

• Clarithromycin-N-methyl-13C, d3

Clarithromycin-D3

CAS: 959119-22-3

Clarithromycin-D3 is the deuterium-labeled form of Clarithromycin, which exhibits broad-spectrum antibacterial activity. It inhibits CYP3A4-catalyzed triazolam α-hydroxylation, with an IC₅₀ (Ki) value of 56 (43) μM. Additionally, Clarithromycin (T1434) significantly inhibits HERG potassium currents and affects autophagic flux by disrupting the signaling pathway linking hERG1 and PI3K.

Formula: C₃₈H₆₉NO₁₃

Molecular weight: 750.97

Ref: TM-TMID-0859

Clarithromycin-N-methyl-d3

Controlled Product

CAS: 959119-22-3

Applications Labelled Clarithromycin (C559750). Clarithromycin is a semi-synthetic macrolide antibiotic. Clarithromycin is a derivative of Erythromycin (E650000).
References Benson, C., et al.: Eur. J. Clin. Microbiol., 6, 173 (1987), Boyanova, L., et al.: J. Med. Microb., 61, 85 (2012), Lin, Z., et al.: Toxicol. Sci., 126, 114 (2012),

Formula: C₃₈D₃H₆₆NO₁₃

Color and Shape: Neat

Molecular weight: 750.9718

Ref: TR-C559752

Clarithromycin-N-methyl-d3

Controlled Product

CAS: 959119-22-3

Please enquire for more information about Clarithromycin-N-methyl-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₃₈H₆₆D₃NO₁₃

Purity: Min. 95%

Molecular weight: 750.97 g/mol

Ref: 3D-IC183141