CAS 960374-59-8

ONX-0914

Description:

ONX-0914, with the CAS number 960374-59-8, is a small molecule inhibitor that specifically targets the proteasome, a critical component of the cellular protein degradation pathway. This compound is known for its selective inhibition of the immunoproteasome, which plays a significant role in the processing of antigens for presentation to the immune system. ONX-0914 has garnered attention in research for its potential therapeutic applications, particularly in the context of autoimmune diseases and certain cancers, where modulation of immune responses may be beneficial. The compound exhibits a favorable pharmacokinetic profile, allowing for effective cellular uptake and activity. Additionally, its mechanism of action involves the disruption of protein homeostasis, leading to the accumulation of pro-apoptotic factors in malignant cells. Overall, ONX-0914 represents a promising avenue for therapeutic intervention, although further studies are necessary to fully elucidate its efficacy and safety in clinical settings.

ONX-0914

CAS: 960374-59-8

(S)-3-(4-Methoxyphenyl)-N-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide

Formula: C₃₁H₄₀N₄O₇

Purity: 99%

Molecular weight: 580.67

Ref: IN-DG304680

(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide

CAS: 960374-59-8

Formula: C₃₁H₄₀N₄O₇

Purity: 99%

Color and Shape: Solid

Molecular weight: 580.6719

Ref: IN-DA00IJRG

ONX-0914

CAS: 960374-59-8

ONX-0914

Formula: C₃₁H₄₀N₄O₇

Purity: ≥98%

Molecular weight: 580.67

Ref: 54-BUP04933

ONX-0914

CAS: 960374-59-8

ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.

Formula: C₃₁H₄₀N₄O₇

Purity: 98.24% - 99.31%

Color and Shape: Solid

Molecular weight: 580.67

Ref: TM-T6029

ONX 0914

CAS: 960374-59-8

Ref: 7W-GW4334

ONX 0914

Controlled Product

CAS: 960374-59-8

Applications ONX 0914 is a proteosome inhibitor known for treatming malignancies and more recently, effacaciously inducing apoptosis for cancers. Used in the treatment of autoimmune diseases.
References Mulder, A. et a.L Transplantation, 95, 1331 (2013); Screen, M. et al.: J. Biol. Chem., 285, 40125 (2010);

Formula: C₃₁H₄₀N₄O₇

Color and Shape: Neat

Molecular weight: 580.67

Ref: TR-O658000