CAS 96445-14-6

(5alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6,10-dione

Description:

The chemical substance known as (5alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6,10-dione, with the CAS number 96445-14-6, is a synthetic derivative of morphinan, a class of compounds that includes various opiates. This substance features a complex molecular structure characterized by multiple functional groups, including hydroxyl (-OH) groups and an epoxide, which contribute to its potential biological activity. The presence of the cyclopropylmethyl group may influence its pharmacokinetic properties, such as absorption and metabolism. Morphinan derivatives are often studied for their analgesic and antitussive properties, and this particular compound may exhibit similar effects. Its specific interactions with opioid receptors and other biological targets would require further investigation through pharmacological studies. Additionally, the stereochemistry indicated by the "5alpha" designation suggests a specific three-dimensional arrangement that can significantly affect the compound's activity and efficacy. Overall, this substance represents a unique entry in the field of medicinal chemistry, with potential applications in pain management and other therapeutic areas.

Formula: C₂₀H₂₁NO₅

InChI: InChI=1/C20H21NO5/c22-12-4-3-11-14-16(12)26-18-13(23)5-6-20(25)17(15(11)24)21(9-10-1-2-10)8-7-19(14,18)20/h3-4,10,17-18,22,25H,1-2,5-9H2/t17-,18+,19+,20-/m1/s1

Synonyms:

• Naltrexone EP Impurity I

10-Oxo Naltrexone

Controlled Product

CAS: 96445-14-6

Impurity Naltrexone EP Impurity I
Applications Naltrexone derivative. It is less potent than Naltrexone (N285750) and Oxymorphone (O876800).
References Archer, S., et al.: J. Med. Chem., 28 974 (1985),

Formula: C₂₀H₂₁NO₅

Color and Shape: Neat

Molecular weight: 355.38

Ref: TR-O858200

10-Oxo Naltrexone (1 mg/ml in Acetonitrile)

Controlled Product

CAS: 96445-14-6

Formula: C₂₀H₂₁NO₅

Color and Shape: Single Solution

Molecular weight: 355.38

Ref: TR-KIT6765

10-Ketonaltrexone - in methanol solution

Controlled Product

CAS: 96445-14-6

10-Ketonaltrexone is an opioid receptor antagonist that binds to the μ- and δ-opioid receptors in the gastrointestinal tract, blocking the effect of opioids. It has been shown to selectively inhibit binding of oxycodone, cyclazocine, and morphine to their receptors in muscle and deferens tissue. 10-Ketonaltrexone has affinity for opioid receptors in ileum tissue and binding sites in the brain. This drug is selective for the μ-receptors over δ-receptors and has no activity against other receptors such as dopamine, serotonin, or histamine. In vitro assays have shown that 10-ketonaltrexone binds with high affinity to human naltrexone binding sites but not to human oxymorphone binding sites.

Formula: C₂₀H₂₁NO₅

Purity: Min. 95%

Molecular weight: 355.38 g/mol

Ref: 3D-FK71982

Naltrexone impurity I

Controlled Product

CAS: 96445-14-6

Naltrexone impurity I is an impurity of naltrexone that can be found in the drug oxymorphone. It is a selective opiate antagonist that binds to opiate receptors in the brain, including those in the myenteric plexus and ileum. The affinity of naltrexone for these binding sites is much lower than that of oxycodone or oxymorphone. This means it will not displace these drugs from their binding sites and will therefore not cause withdrawal symptoms when used as a substitute for these drugs. Naltrexone impurity I also has low affinity for muscle tissue, which makes it suitable for use as a long-acting injectable drug.

Formula: C₂₀H₂₁NO₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 355.38 g/mol

Ref: 3D-IN167109

Naltrexone EP Impurity I

CAS: 96445-14-6

Formula: C₂₀H₂₁NO₅

Molecular weight: 355.4

Ref: ST-EA-CP-N57008