CAS 968-81-0

Acetohexamide

Description:

Acetohexamide is a chemical compound classified as a sulfonylurea, primarily used in the management of type 2 diabetes mellitus. It functions as an oral hypoglycemic agent, stimulating insulin release from the pancreas and enhancing insulin sensitivity in peripheral tissues. The molecular structure of acetohexamide includes a hexamethylene chain and an acetamide group, contributing to its pharmacological properties. It is typically administered in tablet form and is known for its moderate efficacy in lowering blood glucose levels. Acetohexamide has a relatively low solubility in water, which can affect its absorption and bioavailability. Common side effects may include gastrointestinal disturbances, hypoglycemia, and allergic reactions. As with other sulfonylureas, its use requires careful monitoring of blood glucose levels to avoid potential complications. The compound is metabolized in the liver, and its pharmacokinetics can be influenced by factors such as age, liver function, and concurrent medications. Overall, acetohexamide plays a role in diabetes management, although it has largely been replaced by newer agents with improved safety and efficacy profiles.

Formula: C₁₅H₂₀N₂O₄S

InChI: InChI=1/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)

InChI key: InChIKey=VGZSUPCWNCWDAN-UHFFFAOYSA-N

SMILES: S(NC(NC1CCCCC1)=O)(=O)(=O)C2=CC=C(C(C)=O)C=C2

Synonyms:

• 1-(4-Acetylbenzenesulfonyl)-3-Cyclohexylurea
• 1-(4-Acetylphenyl)sulfonyl-3-cyclohexylurea
• 1-(p-Acetylbenzenesulfonyl)-3-cyclohexylurea
• 1-[(p-Acetylphenyl)sulfonyl]-3-cyclohexylurea
• 4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide
• 4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide
• Acetohexamid
• Acetohexamida
• Benzenesulfonamide, 4-acetyl-N-[(cyclohexylamino)carbonyl]-
• Dimelin
• Dimelin (antidiabetic)
• Dimelor
• Dymelor
• Gamadiabet
• Hypoglicil
• Metaglucina
• Minoral
• N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea
• Ordimel
• Tsiklamid
• U 14812
• Urea, 1-[(p-acetylphenyl)sulfonyl]-3-cyclohexyl-
• Acetohexamide
• DyMelor-d6
• -d6 DiMelin-d6
• Hypoglicil-d6
• 4-Acetyl-N-[(cyclohexyl-d6-aMino)carbonyl]benzenesulfonaMide
• Acetohexamide (250 mg)
• AcetohexaMide-d6
• Cyclamide
• 1-(4-acetylphenyl)sulfonyl-3-cyclohexyl-urea
• 1-cyclohexyl-3-(4-ethanoylphenyl)sulfonyl-urea
• gamadiaber
• 1-[(p-Acetylphenyl)su
• 1-((p-acetylphenyl)sulfonyl)-3-cyclohexyl-ure
• GaMadiabet-d6
• 4-acetyl-n-[(cyclohexylamino)carbonyl]-benzenesulfonamid
• nci-c03247
• U 14812-d6
• 4-acetyl-n-benzenesulfonamide
• 1-(p-acetylbenzenesulfonyl)-3-cyclohexylure
• 1-(p-Acetylbenzenesulfonyl)
• OrdiMel-d6
• 4-acetyl-n-((cyclohexylamino)carbonyl)-benzenesulfonamid
• ACETOHEXAMIDE, USP GRADE ORAL HYPOGLYCEM IC AGE
• Metaglucina-d6
• u14812
• TsiklaMid-d6
• Minoral-d6

Acetohexamide

CAS: 968-81-0

Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity.

Formula: C₁₅H₂₀N₂O₄S

Purity: 99.01% - 99.19%

Color and Shape: White Solid

Molecular weight: 324.40

Ref: TM-T0816

Acetohexamide

CAS: 968-81-0

Acetohexamide

Formula: C₁₅H₂₀N₂O₄S

Purity: ≥98%

Molecular weight: 324.4

Ref: 54-BUP14643

Acetohexamide

CAS: 968-81-0

Formula: C₁₅H₂₀N₂O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 324.3953

Ref: IN-DA005SIZ

Acetohexamide

CAS: 968-81-0

Formula: C₁₅H₂₀N₂O₄S

Molecular weight: 324.40

Ref: 7W-GL0522

Acetohexamide

CAS: 968-81-0

Color and Shape: Neat

Ref: 61-FOR1726.00

Acetohexamide (Standard)

CAS: 968-81-0

Acetohexamide (Standard) is the standard substance of Acetohexamide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide.

Formula: C₁₅H₂₀N₂O₄S

Molecular weight: 324.40

Ref: TM-TMSM-0357

Acetohexamide

Controlled Product

CAS: 968-81-0

Applications Acetohexamide is a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diabetes metilus type 2.
References Yu, T-F. et al.: Metab. Clin. Exp., 17, 309 (1968); Harrower, A.D.B. et al.: Clin. Pharmacokin., 31, 111 (1996); Hirota, Y. et al.: Diab. Med., 26, 948 (2009);

Formula: C₁₅H₂₀N₂O₄S

Color and Shape: Neat

Molecular weight: 324.4

Ref: TR-A162650

Acetohexamide

CAS: 968-81-0

Acetohexamide

Formula: C₁₅H₂₀N₂O₄S

Purity: 99%

Molecular weight: 324.4

Ref: IN-DG16071

Acetohexamide

CAS: 968-81-0

Acetohexamide is a hypoglycemic drug that binds to the sulfonylurea receptor on pancreatic beta-cells and stimulates insulin release. It has been shown to have an oral hypoglycemic effect in humans, as well as in rats. Acetohexamide has been shown to inhibit the action of nonsteroidal anti-inflammatory drugs, such as indomethacin, through competitive inhibition. Acetohexamide also inhibits the enzyme activity of estradiol benzoate and acetohexamide hydrolase. This drug is not active against bacteria or fungi, but has been shown to be effective against some viruses. Acetohexamide is absorbed by the gastrointestinal tract and excreted unchanged in urine and feces. The drug does not bind to proteins and does not cross the blood-brain barrier.

Formula: C₁₅H₂₀N₂O₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 324.4 g/mol

Ref: 3D-FA16951