CAS 97240-79-4: Topiramate
Description:Topiramate is a sulfamate-substituted monosaccharide that is primarily used as an anticonvulsant and for the prevention of migraines. Its chemical formula is C12H21N3O8S, and it features a unique structure that includes a sulfamate group, which contributes to its pharmacological properties. Topiramate is known for its ability to inhibit certain neurotransmitter pathways, particularly those involving glutamate, and it enhances the activity of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. This dual mechanism of action makes it effective in controlling seizures and preventing migraine attacks. The substance is typically administered orally and is well-absorbed in the gastrointestinal tract. Topiramate is also associated with a range of side effects, including cognitive impairment, weight loss, and potential metabolic acidosis. Its safety profile and efficacy have made it a widely prescribed medication in neurology and psychiatry. As with any medication, it is important for patients to discuss potential risks and benefits with their healthcare provider.
Formula:C12H21NO8S
InChI:InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
InChI key:InChIKey=KJADKKWYZYXHBB-XBWDGYHZSA-N
SMILES:O=S(=O)(OCC12OCC3OC(OC3C2OC(O1)(C)C)(C)C)N
- Synonyms:
- 2,3:4,5-Bis-O-(1-methylethylidene) β-<span class="text-smallcaps">D</span>-fructopyranose sulfamate
- 2,3:4,5-Bis-O-(1-methylethylidene) β-D-fructopyranose sulfamate
- 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose sulfamate
- 5H-Bis[1,3]dioxolo[4,5-b:4′,5′-d]pyran, β-<span class="text-smallcaps">D</span>-fructopyranose deriv.
- Epitoma
- Epitomax
- McN 4853
- Qudexy XR
- Rwj 17021
- Sincronil
- See more synonyms
- TPM
- Toiramate
- Topamac
- Topamax
- Topimax
- Topina
- Topiragen
- Topomax
- Tracrium
- Trokendi XR
- β-<span class="text-smallcaps">D</span>-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate
- β-<span class="text-smallcaps">D</span>-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
- β-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate
- β-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
- Topiramate
- 5H-Bis[1,3]dioxolo[4,5-b:4′,5′-d]pyran, β-D-fructopyranose deriv.
- 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamate
- Topiramato [INN-Spanish]
- 1-O-Sulfamoyl-2-O,3-O:4-O,5-O-diisopropylidene-β-D-fructopyranose
- Topiramate Synonyms Topamax
- TopiramateTopamax
- Topiramate solution
- 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranoside sulfamate
- 2,3:4,5-Di-O-isopropylidene-b-D-fructopyranosidesulfamate
- Topiramate (150 mg)
- Tipiramato [Spanish]
- 2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranose sulfamate
- RWJ-17021-000
- TopiraMate(McN-4853,RWJ-17021,TopaMax)
- Tipiramate [French]
- Topiramic acid
- .beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
- McN 4853, RWJ 17021, Topamax, 2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate
- 1-O-Sulfamoyl-2-O,3-O:4-O,5-O-bis(1-methylethylidene)-β-D-fructopyranose
- TopiraMate API
- 2,3:4,5-Bis-O-(1-methylethylidene)--D-fuctopyranose Sulfamate, McN-4853, RWJ-17021-000, Topamax
- ((3aS,5aR,8aR,8bS)-2,2,7,7-tetraMethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)Methyl sulfaMate
- ((3AS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl
- 2,3:4,5-Bis-O-(1-Methylethylidene)-β-D-fuctopyranose 1-SulfaMate
- Topiramatum [INN-Latin]
- TopiriMate-d12
- 2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-B-D-FUCTO-PYRANOSE SULFAMATE
- Topiramate [USAN:BAN:INN]
- PHARMACEUTICAL RAW MATERIAL: TOPIRAMATEUSP
- topiramatum [Latin]
- 2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranossulfamate
- 2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-36-D-FRUCTO-PYRANOSE SULFAMATE
- 2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulfamate
- 2,3:4,5-Di-O-isopropylidene-1-O-sulfamoyl-beta-D-fructopyranose
- Topiramate, >=98%
- 2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-BETA-D-FUCTOPYRANOSE SULFAMATE
- 2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fuctopyranose Sulfamate, McN-4853, RWJ-17021-000, Topamax