CAS 97322-87-7
:Troglitazone
Description:
Troglitazone is a synthetic compound belonging to the thiazolidinedione class of medications, primarily used in the management of type 2 diabetes mellitus. It functions as a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, which enhances insulin sensitivity and promotes glucose uptake in peripheral tissues. Troglitazone is characterized by its ability to modulate lipid metabolism and improve glycemic control. The compound has a molecular formula that includes carbon, hydrogen, nitrogen, oxygen, and sulfur atoms, contributing to its unique structure and biological activity. However, its clinical use has been limited due to concerns regarding hepatotoxicity, leading to its withdrawal from the market in several countries. Despite its efficacy in lowering blood glucose levels, the risk of liver damage has overshadowed its benefits, prompting the need for careful monitoring in patients. Troglitazone serves as a significant example of the complexities involved in drug development and the importance of balancing therapeutic effects with safety profiles.
Formula:C24H27NO5S
InChI:InChI=1/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
InChI key:InChIKey=GXPHKUHSUJUWKP-UHFFFAOYSA-N
SMILES:CC1=C2C(CCC(COC3=CC=C(CC4C(=O)NC(=O)S4)C=C3)(C)O2)=C(C)C(O)=C1C
Synonyms:- (+/-)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione
- 2,4-Thiazolidinedione, 5-[[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-
- 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
- Ci 991
- Cs 045
- Depotox
- Gr 92132X
- Noscal
- Rezulin
- Romglizone
- Troglitazone
- 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, CS-045, CI-991,Noscal,
- 2,4-thiazolidinedione,5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-b
- 5-[[4-[(3,4-DIHYDRO-6-HYDROXY-2,5,7,8-TETRAMETHYL-2H-1-BENZOPYRAN-2-YL)METHOXY]PHENYL]METHYL]-2,4-THIOAZOLIDINEDIONE
- 5-(4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2
- AKOS 91980
- gr92132x
- ci991
- 5-[[4-((3,4-DIHYDRO-6-HYDROXY-2,5,7,8-TETRAMETHYL-2H-1-BENZOPYRAN-2-YL)METHOXY)PHENYL]METHYL]-2,4-TH
- enzopyran-2-yl)methoxy)phenyl)methyl)-
- Troglitazone for research
- RESULIN(TM)
- TroglitazoneMesylate
- See more synonyms
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Troglitazone
CAS:Formula:C24H27NO5SPurity:>98.0%(HPLC)Color and Shape:White to Orange to Green powder to crystalineMolecular weight:441.54Troglitazone
CAS:Formula:C24H27NO5SPurity:≥ 97.0%Color and Shape:White to off-white solidMolecular weight:441.545-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
CAS:Formula:C24H27NO5SPurity:98%Color and Shape:SolidMolecular weight:441.5399Troglitazone
CAS:Controlled ProductApplications Troglitazone is an an oral hypoglycemic agent which improves insulin sensitivity and decreases hepatic glucose production. Antidiabetic.
References Ciaraldi, T.P., et al.: Metabolism, 39, 1056 (1990), Kuzuya, T., et al.: Diabetes Res. Clin. Pract., 11, 147 (1991), Kellerer, M., et al.: Diabetes, 43, 447 (1994),Formula:C24H27NO5SColor and Shape:NeatMolecular weight:441.545-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)thiazolidine-2,4-dione
CAS:5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)thiazolidine-2,4-dioneFormula:C24H27NO5SPurity:98%Molecular weight:441.54Troglitazone
CAS:Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.Formula:C24H27NO5SPurity:98% - 99.8%Color and Shape:SolidMolecular weight:441.54Troglitazone
CAS:Controlled ProductPPAR-γ agonist; anti-diabetic agent
Formula:C24H27NO5SPurity:Min. 95%Color and Shape:PowderMolecular weight:441.54 g/mol
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