CAS 976-71-6: Canrenone

Description: Canrenone is a synthetic compound classified as a steroid and is primarily known for its role as a potassium-sparing diuretic. It is derived from spironolactone and functions by antagonizing aldosterone receptors, which helps in the regulation of sodium and potassium levels in the body. Canrenone is often used in the treatment of conditions such as hypertension and edema, particularly in patients who require diuretic therapy without the risk of significant potassium loss. The substance is characterized by its relatively low solubility in water, but it is soluble in organic solvents. Its chemical structure includes a lactone ring, which is essential for its biological activity. Canrenone is metabolized in the liver, and its pharmacokinetics can be influenced by various factors, including liver function and concurrent medications. As with any medication, potential side effects may include electrolyte imbalances, particularly hyperkalemia, and hormonal effects due to its steroid-like properties. Overall, Canrenone is an important therapeutic agent in managing fluid balance and blood pressure.

Formula: C₂₂H₂₈O₃

InChI: InChI=1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1

InChI key: InChIKey=UJVLDDZCTMKXJK-WNHSNXHDSA-N

SMILES: O=C1OC2(CC1)CCC3C4C=CC5=CC(=O)CCC5(C)C4CCC32C

Synonyms:

• (10R,13S,17R)-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
• (8R,9S,10R,13S,14S,17R)-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
• 10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
• 11614 R. P.
• 17-Hydroxy-3-oxo-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactone
• 17-Hydroxy-3-oxo-17α-pregna-4,6-diene-21-carboxylic acid lactone
• 17-Hydroxy-3-oxo-17α-pregna-4,6-diene-21-carboxylic acid γ-lactone
• 17alpha-(2-Carboxyethyl)-17beta-hydroxyandrosta-4,6-dien-3-one lactone
• 17alpha-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone (8CI)
• 17α-(2-Carboxyethyl)-17β-hydroxyandrosta-4,6-dien-3-one lactone
• 17α-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone
• 17β-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid
• 20-Spiroxa-4,6-diene-3,21-dione
• 3-(17β-Hydroxy-3-oxoandrosta-4,6-dien-17α-yl)propionic acid lactone
• 3-(17β-Hydroxy-3-oxoandrosta-4,6-dien-17α-yl)propionic acid γ-lactone
• 3-(3-Oxo-17β-hydroxy-4,6-androstadien-17α-yl)propionic acid γ-lactone
• 3′-(3-Oxo-17β-hydroxyandrosta-4,6-dien-17α-yl)-propionic acid lactone
• Aldadiene
• Aldadiene (VAN)
• Brn 0046602
• Canrenona
• Canrenona [INN-Spanish]
• Canrenone [USAN:INN]
• Canrenonum
• Canrenonum [INN-Latin]
• Luvion
• Nsc 261713
• Phanurane
• Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone (17alpha)-
• Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, (17α)-
• Rp 11641
• Sc 9376
• Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregna-4,6-diene-21-carboxylic acid deriv.
• Spirolactone SC 14266
• Unii-78O20X9J0U
• Canrenone

Canrenone, 98%

CAS: 976-71-6

Inhibits aldosterone biosynthesis and blocks ouabain effects This Thermo Scientific Chemicals brand product was originally …

• Formula: C₂₂H₂₈O₃
• Purity: 98%
• Molecular weight: 340.46

Canrenone CRS

CAS: 976-71-6

• Formula: C₂₂H₂₈O₃
• Molecular weight: 340.4559

Spironolactone Related Compound A ((2'R)-3',4'-Dihydro-5'H-spiro[androst-4,6-diene-17,2'-furan]-3,5'-dione)

CAS: 976-71-6

Adrenal cortical hormones and their derivatives nesoi

• Formula: C₂₂H₂₈O₃
• Color and Shape: Light Yellow Crystalline Powder
• Molecular weight: 340.20384

Canrenone

CAS: 976-71-6

Canrenone (SC14266) is an aldosterone antagonist with potassium-sparing diuretic activity.

• Formula: C₂₂H₂₈O₃
• Purity: 99.88%
• Color and Shape: Solid
• Molecular weight: 340.46

Spironolactone EP Impurity F (Canrenone)

CAS: 976-71-6

• Formula: C₂₂H₂₈O₃
• Color and Shape: Yellow Solid
• Molecular weight: 340.46

Spironolactone EP Impurity F-d4 (Canrenone-d4)

CAS: 976-71-6

• Formula: C₂₂H₂₄D₄O₃
• Color and Shape: Pale Yellow Solid
• Molecular weight: 344.49

Canrenone

CAS: 976-71-6

• Formula: C₂₂H₂₈O₃
• Molecular weight: 340.46

3',4'-Dihydrospiro[androst-4,6-diene-17,2'(5'H)-furan]-3,5'-dione (Canrenone)

CAS: 976-71-6

• Formula: C₂₂H₂₈O₃
• Color and Shape: Neat
• Molecular weight: 340.46

Canrenone

CAS: 976-71-6

• Formula: C₂₂H₂₈O₃
• Color and Shape: Neat
• Molecular weight: 340.46

Spironolactone EP Impurity F-d6 (Canrenone-d6)

CAS: 976-71-6

• Formula: C₂₂H₂₂O₃D₆
• Molecular weight: 346.50

Canrenone

CAS: 976-71-6

Impurity Spironolactone EP Impurity F Applications Canrenone (Spironolactone EP Impurity F) is an aldosterone antagonist. …

• Formula: C₂₂H₂₈O₃
• Color and Shape: Light Yellow Solid
• Molecular weight: 340.46

Canrenone-d6 (Major)

CAS: 976-71-6

Applications Labelled Aldosterone antagonist. Diuretic. Not a dangerous good if item is equal to or …

• Formula: C₂₂H₂₂D₆O₃
• Color and Shape: Light Yellow To Dark Yellow
• Molecular weight: 346.49

Canrenone - Bio-X ™

CAS: 976-71-6

Canrenone is a steroidal antimineralcorticoid that is used as a diuretic. It has been shown …

• Formula: C₂₂H₂₈O₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 340.46 g/mol

Canrenone

CAS: 976-71-6

Mineralocorticoid (aldosterone) receptor antagonist

• Formula: C₂₂H₂₈O₃
• Purity: Min. 97 Area-%
• Color and Shape: Powder
• Molecular weight: 340.46 g/mol

Canrenone - 95%

CAS: 976-71-6

Mineralocorticoid (aldosterone) receptor antagonist

• Formula: C₂₂H₂₈O₃
• Purity: Min. 95 Area-%
• Color and Shape: Powder
• Molecular weight: 340.46 g/mol