CAS 976-71-6
:Canrenone
Description:
Canrenone is a synthetic compound classified as a steroid and is primarily known for its role as a potassium-sparing diuretic. It is derived from spironolactone and functions by antagonizing aldosterone receptors, which helps in the regulation of sodium and potassium levels in the body. Canrenone is often used in the treatment of conditions such as hypertension and edema, particularly in patients who require diuretic therapy without the risk of significant potassium loss. The substance is characterized by its relatively low solubility in water, but it is soluble in organic solvents. Its chemical structure includes a lactone ring, which is essential for its biological activity. Canrenone is metabolized in the liver, and its pharmacokinetics can be influenced by various factors, including liver function and concurrent medications. As with any medication, potential side effects may include electrolyte imbalances, particularly hyperkalemia, and hormonal effects due to its steroid-like properties. Overall, Canrenone is an important therapeutic agent in managing fluid balance and blood pressure.
Formula:C22H28O3
InChI:InChI=1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
InChI key:InChIKey=UJVLDDZCTMKXJK-WNHSNXHDSA-N
SMILES:C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C=C4)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3
Synonyms:- (10R,13S,17R)-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
- (8R,9S,10R,13S,14S,17R)-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
- 10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
- 11614 R. P.
- 17-Hydroxy-3-oxo-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactone
- 17-Hydroxy-3-oxo-17α-pregna-4,6-diene-21-carboxylic acid lactone
- 17-Hydroxy-3-oxo-17α-pregna-4,6-diene-21-carboxylic acid γ-lactone
- 17alpha-(2-Carboxyethyl)-17beta-hydroxyandrosta-4,6-dien-3-one lactone
- 17alpha-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone (8CI)
- 17α-(2-Carboxyethyl)-17β-hydroxyandrosta-4,6-dien-3-one lactone
- 17α-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone
- 17β-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid
- 20-Spiroxa-4,6-diene-3,21-dione
- 3-(17β-Hydroxy-3-oxoandrosta-4,6-dien-17α-yl)propionic acid lactone
- 3-(17β-Hydroxy-3-oxoandrosta-4,6-dien-17α-yl)propionic acid γ-lactone
- 3-(3-Oxo-17β-hydroxy-4,6-androstadien-17α-yl)propionic acid γ-lactone
- 3′-(3-Oxo-17β-hydroxyandrosta-4,6-dien-17α-yl)-propionic acid lactone
- Aldadiene
- Aldadiene (VAN)
- Brn 0046602
- Canrenona
- Canrenona [INN-Spanish]
- Canrenone [USAN:INN]
- Canrenonum
- Canrenonum [INN-Latin]
- Luvion
- Nsc 261713
- Phanurane
- Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone (17alpha)-
- Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, (17α)-
- Rp 11641
- Sc 9376
- Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregna-4,6-diene-21-carboxylic acid deriv.
- Spirolactone SC 14266
- Unii-78O20X9J0U
- See more synonyms
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Found 16 products.
Canrenone, 98%
CAS:Inhibits aldosterone biosynthesis and blocks ouabain effectsFormula:C22H28O3Purity:98%Molecular weight:340.46Spironolactone Related Compound A ((2'R)-3',4'-Dihydro-5'H-spiro[androst-4,6-diene-17,2'-furan]-3,5'-dione)
CAS:Adrenal cortical hormones and their derivatives nesoiFormula:C22H28O3Color and Shape:Light Yellow Crystalline PowderMolecular weight:340.20384Canrenone
CAS:Canrenone (SC14266) is an aldosterone antagonist with potassium-sparing diuretic activity.Formula:C22H28O3Purity:99.88%Color and Shape:SolidMolecular weight:340.46Spironolactone EP Impurity F-2,2,20,20-d4 (Spironolactone USP Related Compound A-2,2,20,20-d4, Canrenone-2,2,20,20-d4)
CAS:Formula:C22H24D4O3Color and Shape:Pale Yellow SolidMolecular weight:344.49Spironolactone EP Impurity F (Spironolactone USP Related Compound A, Canrenone)
CAS:Formula:C22H28O3Color and Shape:Yellow SolidMolecular weight:340.463',4'-Dihydrospiro[androst-4,6-diene-17,2'(5'H)-furan]-3,5'-dione (Canrenone)
CAS:Color and Shape:NeatCanrenone
CAS:Controlled ProductFormula:C22H28O3Color and Shape:Light Yellow SolidMolecular weight:340.46Spironolactone EP Impurity F-d6 (Spironolactone USP Related Compound A-d6, Canrenone-d6)
CAS:Formula:C22H22D6O3Molecular weight:346.50Canrenone-d6 (Major)
CAS:Controlled ProductApplications Labelled Aldosterone antagonist. Diuretic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sadee, W., et al.: J. Pharmacol. Exp. Ther., 185, 686 (1973), Pitt, B., et al.: Circulation, 108, 1831 (2003), Silvestre, J., et al.: J. Biol. Chem., 273, 4883 (1998), Struthers, A., et al.: Heart, 92, 1728 (2006),Formula:C22H22D6O3Color and Shape:Light Yellow To Dark YellowMolecular weight:346.49Thiothiamine
CAS:Impurity Spironolactone EP Impurity F
Applications Canrenone (Spironolactone EP Impurity F) is an aldosterone antagonist. Diuretic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sadee, W., et al.: J. Pharmacol. Exp. Ther., 185, 686 (1973), Pitt, B., et al.: Circulation, 108, 1831 (2003), Silvestre, J., et al.: J. Biol. Chem., 273, 4883 (1998), Struthers, A., et al.: Heart, 92, 1728 (2006),Formula:C22H28O3Color and Shape:Light Yellow SolidMolecular weight:340.46Canrenone - Bio-X ™
CAS:Controlled ProductCanrenone is a steroidal antimineralcorticoid that is used as a diuretic. It has been shown to reduce blood pressure and increase urine volume. Also, this drug has shown to be effective in treating hirsutism in women.Formula:C22H28O3Purity:Min. 95%Color and Shape:PowderMolecular weight:340.46 g/molCanrenone
CAS:Controlled ProductMineralocorticoid (aldosterone) receptor antagonistFormula:C22H28O3Purity:Min. 97 Area-%Color and Shape:PowderMolecular weight:340.46 g/molCanrenone - 95%
CAS:Controlled ProductMineralocorticoid (aldosterone) receptor antagonist
Formula:C22H28O3Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:340.46 g/mol
![3',4'-Dihydrospiro[androst-4,6-diene-17,2'(5'H)-furan]-3,5'-dione (Canrenone)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F86%2Fthumb%2FMM0197.01-0250.jpg&w=3840&q=75)
