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CAS 98-96-4

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Pyrazinamide

Description:
Pyrazinamide is a synthetic compound primarily used as an antitubercular medication. It is classified as a pyrazine derivative and is known for its effectiveness against Mycobacterium tuberculosis, particularly in the treatment of active tuberculosis. The chemical formula of pyrazinamide is C5H5N3O, and it features a pyrazine ring with an amide functional group. This compound is typically administered orally and is well-absorbed in the gastrointestinal tract. Pyrazinamide exhibits bactericidal activity, especially in acidic environments, which is significant for its action in the macrophages where the tuberculosis bacteria often reside. Its mechanism of action involves the inhibition of fatty acid synthesis, disrupting the bacterial cell wall. Common side effects may include hepatotoxicity, hyperuricemia, and gastrointestinal disturbances. Due to its unique properties, pyrazinamide is often included in combination therapy regimens for tuberculosis, particularly in the initial phase of treatment. Its use has been pivotal in reducing the duration of therapy required for effective tuberculosis management.
Formula:C5H5N3O
InChI:InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
InChI key:InChIKey=IPEHBUMCGVEMRF-UHFFFAOYSA-N
SMILES:C(N)(=O)C=1C=NC=CN1
Synonyms:
  • 2-(Aminocarbonyl)pyrazine
  • 2-Carbamylpyrazine
  • 2-Carboxamidopyrazine
  • 2-​ Pyrazinecarboxamide
  • Aldinamid
  • Aldinamide
  • D 50
  • Eprazin
  • Farmizina
  • Isopas
  • See more synonyms
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