CAS 98-96-4
:Pyrazinamide
Description:
Pyrazinamide is a synthetic compound primarily used as an antitubercular medication. It is classified as a pyrazine derivative and is known for its effectiveness against Mycobacterium tuberculosis, particularly in the treatment of active tuberculosis. The chemical formula of pyrazinamide is C5H5N3O, and it features a pyrazine ring with an amide functional group. This compound is typically administered orally and is well-absorbed in the gastrointestinal tract. Pyrazinamide exhibits bactericidal activity, especially in acidic environments, which is significant for its action in the macrophages where the tuberculosis bacteria often reside. Its mechanism of action involves the inhibition of fatty acid synthesis, disrupting the bacterial cell wall. Common side effects may include hepatotoxicity, hyperuricemia, and gastrointestinal disturbances. Due to its unique properties, pyrazinamide is often included in combination therapy regimens for tuberculosis, particularly in the initial phase of treatment. Its use has been pivotal in reducing the duration of therapy required for effective tuberculosis management.
Formula:C5H5N3O
InChI:InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
InChI key:InChIKey=IPEHBUMCGVEMRF-UHFFFAOYSA-N
SMILES:C(N)(=O)C=1C=NC=CN1
Synonyms:- 2-(Aminocarbonyl)pyrazine
- 2-Carbamylpyrazine
- 2-Carboxamidopyrazine
- 2- Pyrazinecarboxamide
- Aldinamid
- Aldinamide
- D 50
- Eprazin
- Farmizina
- Isopas
- Mk 56
- Novamid
- Nsc 14911
- Pirazimida
- Pirazinamid
- Pirazinamida
- Pyrafat
- Pyramizade
- Pyrazide
- Pyrazinamid
- Pyrazine carboxylamide
- Pyrazine-2-Carboxamide
- Pyrazinecarboxamide
- Pyrazinecarboxylic acid amide
- Pyrazinoic acid amide
- Rifafour e-200
- Rifcin
- Rozide
- Tebrazid
- Unipyranamide
- Zinamide
- See more synonyms
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Pyrazinamide
CAS:Formula:C5H5N3OPurity:>98.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:123.12Pyrazinamide
CAS:PyrazinamideFormula:C5H5N3OPurity:98.9%Color and Shape:White To Off-WhiteMolecular weight:123.04326Pyrazinamide
CAS:Acriflavine; acriflavine hydrochloride; carbadox; and pFormula:C5H5N3OColor and Shape:White Crystalline PowderMolecular weight:123.11Pyrazinamide
CAS:Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amideFormula:C5H5N3OPurity:99.71% - 99.95%Color and Shape:Crystals Physical Description White Powder Sublimes From 318°F (Ntp 1992)Molecular weight:123.11Pyrazinecarboxamide
CAS:Formula:C5H5N3OPurity:≥ 99.0% (anhydrous)Color and Shape:White powderMolecular weight:123.11Pyrazinecarboxamide, BP, Ph. Eur., USP grade
CAS:Formula:C5H5N3OPurity:99.0 - 101.0 % (BP, Ph. Eur.)Color and Shape:White crystalline powderMolecular weight:123.11Pyrazinamide
CAS:Controlled ProductFormula:C5H5N3OColor and Shape:White To Off-WhiteMolecular weight:123.11Pyrazinamide
CAS:Controlled ProductFormula:C5H5N3OColor and Shape:White To Off-WhiteMolecular weight:123.11Pyrazine-2-carboxamide
CAS:Pyrazine-2-carboxamideFormula:C5H5N3OPurity:99%Color and Shape:White Solid-PowderMolecular weight:123.11269Pyrazinamide
CAS:Controlled ProductApplications Antibacterial (tuberculostatic).
References Weiner, I.M., et al.: J. Pharmacol. Exp. Ther., 180, 411 (1972), Feldner, E., et al.: Anal. Profiles Drug Subs., 12, 433 (1983)Formula:C5H5N3OColor and Shape:NeatMolecular weight:123.11Pirazinecarboxamide
CAS:Pirazinecarboxamide (Pyrazinamide) is an antitubercular agent with action on Mycobacterium tuberculosis by disrupting membrane energetics and is used for treating tuberculosis in combination with other drugs.Formula:C5H5N3OPurity:Min. 95%Color and Shape:PowderMolecular weight:123.11 g/mol
