CAS 98015-53-3

Carbonochloridic acid, 1,2,2,2-tetrachloroethyl ester

Description:

Carbonochloridic acid, 1,2,2,2-tetrachloroethyl ester, identified by the CAS number 98015-53-3, is an organochlorine compound characterized by its structure, which includes a carbonyl group (C=O) bonded to a tetrachloroethyl moiety. This compound is typically a colorless to pale yellow liquid with a distinctive odor. It is known for its high density and low volatility, making it less likely to evaporate quickly. The presence of multiple chlorine atoms contributes to its chemical stability and reactivity, particularly in nucleophilic substitution reactions. Carbonochloridic acid esters are often used in organic synthesis and may serve as intermediates in the production of various chemicals. However, due to the potential environmental and health impacts associated with chlorinated compounds, handling and disposal must be conducted with caution. Safety data sheets should be consulted for specific handling guidelines, as exposure can pose risks. Overall, this compound exemplifies the characteristics typical of chlorinated organic substances, including persistence in the environment and potential bioaccumulation.

Formula: C₃HCl₅O₂

InChI: InChI=1S/C3HCl5O2/c4-1(3(6,7)8)10-2(5)9/h1H

InChI key: InChIKey=RINXZIYBNVEZRT-UHFFFAOYSA-N

SMILES: C(OC(Cl)=O)(C(Cl)(Cl)Cl)Cl

Synonyms:

• (1R)-1,2,2,2-Tetrachloroethyl chloroformate
• 1,2,2,2,Tetrachloroethyl chloroformate
• 1,2,2,2-Tetrachloroethyl carbonochloridate
• Carbonochloridic acid, 1,2,2,2-tetrachloroethyl ester
• Formic acid, chloro-, 1,2,2,2-tetrachloroethyl ester

Carbonochloridic Acid 1,2,2,2-Tetrachloroethyl Ester

Controlled Product

CAS: 98015-53-3

Applications Carbonochloridic Acid 1,2,2,2-Tetrachloroethyl Ester is used in the synthesis of Doxorubicin (D558000), is used as an antineoplastic. Also used in the synthesis of metabolites of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic.
References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969), Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984); Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)

Formula: C₃HCl₅O₂

Color and Shape: Neat

Molecular weight: 246.304

Ref: TR-C176645