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CAS 98079-51-7

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Lomefloxacin

Description:
Lomefloxacin is a synthetic antibiotic belonging to the fluoroquinolone class, primarily used to treat bacterial infections. It exhibits broad-spectrum antibacterial activity, particularly against Gram-negative and some Gram-positive bacteria. The compound functions by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription, thereby preventing bacterial cell division. Lomefloxacin is typically administered orally and is well-absorbed in the gastrointestinal tract. Its pharmacokinetics include a relatively long half-life, allowing for once or twice daily dosing. The drug is metabolized in the liver and excreted primarily through the kidneys. Common side effects may include gastrointestinal disturbances, central nervous system effects, and potential photosensitivity. Due to its mechanism of action, lomefloxacin is effective in treating various infections, including urinary tract infections and respiratory tract infections. However, its use may be limited by the emergence of antibiotic resistance and potential adverse effects, necessitating careful consideration in clinical settings. As with all antibiotics, it is essential to use lomefloxacin judiciously to minimize resistance development.
Formula:C17H19F2N3O3
InChI:InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)
InChI key:InChIKey=ZEKZLJVOYLTDKK-UHFFFAOYSA-N
SMILES:C(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CC(F)=C(C2F)N3CC(C)NCC3
Synonyms:
  • 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-
  • Lomefloxacin
  • 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
  • 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-2,3-dihydroquinoline-3-carboxylic acid
  • DM 10
  • SC 47111A
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