CAS 98753-19-6

Cefpirome sulfate

Description:

Cefpirome sulfate is a broad-spectrum cephalosporin antibiotic, classified under the fourth generation of cephalosporins. It is primarily used to treat a variety of bacterial infections, particularly those caused by Gram-negative bacteria, including Pseudomonas aeruginosa. Cefpirome exhibits a high degree of stability against beta-lactamases, enzymes produced by some bacteria that can inactivate many antibiotics. The compound is typically administered via injection and is known for its favorable pharmacokinetic properties, including good tissue penetration and a relatively long half-life, which allows for less frequent dosing. Its mechanism of action involves inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Cefpirome sulfate is generally well-tolerated, but like all antibiotics, it may cause side effects, including allergic reactions and gastrointestinal disturbances. It is important to use this antibiotic judiciously to minimize the risk of developing antibiotic resistance. As with any medication, its use should be guided by susceptibility testing and clinical judgment.

Formula: C₂₂H₂₃N₆O₅S₂·HO₄S

InChI: InChI=1S/C22H22N6O5S2.H2O4S/c1-33-26-15(13-10-35-22(23)24-13)18(29)25-16-19(30)28-17(21(31)32)12(9-34-20(16)28)8-27-7-3-5-11-4-2-6-14(11)27;1-5(2,3)4/h3,5,7,10,16,20H,2,4,6,8-9H2,1H3,(H3-,23,24,25,29,31,32);(H2,1,2,3,4)/b26-15-;/t16-,20-;/m1./s1

InChI key: InChIKey=RKTNPKZEPLCLSF-QHBKFCFHSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C3=CSC(N)=N3)=O)C2=O)(SCC1C[N+]4=C5C(CCC5)=CC=C4)[H].S(=O)(=O)([O-])O

Synonyms:

• 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-6,7-dihydro-5H-cyclopenta[b]pyridinium sulfate
• 1-{[(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-6,7-dihydro-5H-cyclopenta[b]pyridinium hydrogen sulfate
• 5H-Cyclopenta[b]pyridinium, 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-6,7-dihydro-, sulfate (1:1)
• Broact
• Cefpirome sulphate
• HR 810 sulfate
• Keiten
• Cefpirome sulfate
• Cefpirome  Sulfate

Cefpirome Sulfate

CAS: 98753-19-6

Formula: C₂₂H₂₂N₆O₅S₂·H₂SO₄

Purity: >95.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 612.65

Ref: 3B-C3007

Cefpirome sulfate, 95%

CAS: 98753-19-6

A fourth generation cephalosporin antibiotic

Formula: C₂₂H₂₂N₆O₅S₂•H₂SO₄

Purity: 95%

Molecular weight: 612.66

Ref: 02-J66001

Cefpirome Sulfate

CAS: 98753-19-6

Cefpirome Sulfate

Formula: C₂₂H₂₄N₆O₉S₃

Purity: Cefpirome≥82%

Color and Shape: Solid

Molecular weight: 612.66

Ref: 54-OR1028549

Cefpirome sulfate

CAS: 98753-19-6

Formula: C₂₂H₂₄N₆O₉S₃

Purity: ≥ 760μg/mg (Cefpirome on dry basis)

Color and Shape: White to pale yellow crystalline powder

Molecular weight: 612.66

Ref: 7W-GA2123

Cefpirome sulfate

CAS: 98753-19-6

Cefpirome sulfate

Formula: C₂₂H₂₄N₆O₉S₃

Purity: 97.5%

Molecular weight: 612.66

Ref: 54-BUP18565

Cefpirome sulfate

Controlled Product

CAS: 98753-19-6

Formula: C₂₂H₂₂N₆O₅S₂·H₂O₄S

Color and Shape: Neat

Molecular weight: 612.66

Ref: 04-C11064500

1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-6,7-dihydro-5H-Cyclopenta[b]pyridinium sulfate

CAS: 98753-19-6

Formula: C₂₂H₂₄N₆O₉S₃

Purity: 82%

Color and Shape: Solid

Molecular weight: 612.6558

Ref: IN-DA00IK5Y

Cefpirome Sulfate

Controlled Product

CAS: 98753-19-6

Applications Fourth generation cephalosporin antibiotic.
References Kavi, J., et al.: J. Antimicrob. Chemother., 22, 911 (1988), Horstmann, G., et al.: Arzneim.-Forsch., 40, 1250 (1990),

Formula: C₂₂H₂₂N₆O₅S₂·H₂O₄S

Color and Shape: Neat

Molecular weight: 612.66

Ref: TR-C243500

Cefpirome sulfate

CAS: 98753-19-6

Cefpirome sulfate (HR-810 sulfate) is a fourth generation cephalosporin antibiotic.

Formula: C₂₂H₂₄N₆O₉S₃

Purity: 97.52%

Color and Shape: White Solid

Molecular weight: 612.66

Ref: TM-T4995

Cefpirome Sulfate

CAS: 98753-19-6

Formula: C₂₂H₂₂N₆O₅S₂·H₂O₄S

Molecular weight: 514.58 98.07

Ref: 4Z-C-296001

Cefpirome sulfate

CAS: 98753-19-6

Formula: C₂₂H₂₄N₆O₉S₃

Molecular weight: 612.7

Ref: BE-BePure-21007

Cefpirome sulfate

CAS: 98753-19-6

Formula: C₂₂H₂₄N₆O₉S₃

Molecular weight: 612.7

Ref: BE-RMCC143001

Cefpirome Sulfate

CAS: 98753-19-6

Formula: C₂₂H₂₃N₆O₅S₂HO₄S

Molecular weight: 515.6 : 97.1

Ref: ST-EA-CP-C212000

Cefpirome sulfate

CAS: 98753-19-6

Cefpirome sulfate is a cephalosporin antibiotic that has been used in the treatment of infectious diseases. It is active against a wide range of microorganisms, including Gram-positive and Gram-negative bacteria and mycoplasma. Cefpirome sulfate is given for intravenous injection as an alternative to glucose. The drug binds to the cell wall of bacteria, causing lysis and cell death. Cefpirome sulfate also inhibits bacterial growth by inhibiting protein synthesis at the level of the ribosome, where it binds to the 50S subunit. This binding prevents peptide chain elongation and affects RNA synthesis by impairing translocation of tRNA from the A site on the ribosome to the P site on the ribosome. Thermodynamic data show that cefpirome sulfate has a high degree of stability in human serum compared with vancomycin hydrochloride (another cephalosporin antibiotic).

Formula: C₂₂H₂₄N₆O₉S₃

Purity: Min. 95 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 612.66 g/mol

Ref: 3D-FC19865