CAS 992-21-2

Lymecycline

Description:

Lymecycline is a semi-synthetic antibiotic belonging to the tetracycline class, primarily used to treat various bacterial infections. It exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria by inhibiting protein synthesis through binding to the 30S ribosomal subunit. This action prevents the growth and reproduction of bacteria. Lymecycline is characterized by its stability in acidic environments, which enhances its bioavailability when administered orally. It is often prescribed for conditions such as acne, respiratory tract infections, and certain skin infections. The compound is generally well-tolerated, although it may cause side effects such as gastrointestinal disturbances, photosensitivity, and potential effects on bone and teeth development in children. As with other tetracyclines, it is contraindicated in pregnant women and young children due to the risk of tooth discoloration and skeletal effects. Lymecycline's pharmacokinetics involve absorption in the gastrointestinal tract, with distribution to various tissues, and it is primarily excreted through the kidneys.

Formula:C₂₉H₃₈N₄O₁₀

InChI:InChI=1/C29H38N4O10/c1-28(42)13-7-6-9-17(34)18(13)22(35)19-14(28)11-15-21(33(2)3)23(36)20(25(38)29(15,43)24(19)37)26(39)32-12-31-16(27(40)41)8-4-5-10-30/h6-7,9,14-16,21,31-32,34-35,39,42-43H,4-5,8,10-12,30H2,1-3H3,(H,40,41)/b26-20+/t14?,15-,16?,21-,28+,29-/m0/s1

InChI key:InChIKey=AHEVKYYGXVEWNO-UEPZRUIBSA-N

SMILES:O[C@@]12[C@@](C[C@]3(C(=C1O)C(=O)C=4C([C@@]3(C)O)=CC=CC4O)[H])([C@H](N(C)C)C(O)=C(C(NCNCCCC[C@@H](C(O)=O)N)=O)C2=O)[H]

Synonyms:

(+)-N-(5-Amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, lysinemethylene deriv.
L-Lysine, N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-
L-Lysine, N6-[[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-, [4S-(4α,4aα,5aα,6β,12aα)]-
Armyl
Ciclisin
Ciclolysal
Ciclolysine
Infaciclina
L-Lysine, N6-[[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-, [4S-(4α,4aα,5aα,6β,12aα)]-
Limeciclina
Lisinbiotic
Lisinciclina
Lymecyclin
Lymecycline
Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-
Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-, L-
Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-
Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-, L-
Mucomycin
N-Lysinomethyltetracycline
N2-[[(+)-5-Amino-5-carboxypentylamino]methyl]tetracycline
N6-[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]lysine
N6-[[[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-oxtahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-L-lysine
N2-[[(+)-5-Amino-5-carboxypentylamino]methyl]tetracycline
N6-[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]lysine
N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-L-lysine
Tertamyl
Tetracycline-L-methylenelysine
Tetracycline-L-methylenelysine
Tetracyclinemethylenelysine
Tetralisal
Tetralysal
Tetramyl
Vebicyclysal
L-Lysine, N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-
N~2~-({[(Z)-[(4aS,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracen-2(1H)-ylidene](hydroxy)methyl]amino}methyl)lysine
(2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
N~2~-({[(E)-[(4S,4aS,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracen-2(1H)-ylidene](hydroxy)methyl]amino}methyl)lysine
N-(N2-lysinomethyl)tetracycline
N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-L-lysine
lymecycline USP/EP/BP
Lymecycline (85%)
N6-[[(4S)-4β-(Dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,6α,10,12,12aβ-pentahydroxy-6-methyl-1,11-dioxonaphthacen-2-yl]carbonylaminomethyl]-L-lysine
Tetracyclinemethylene lysine
See more synonyms

Found 10 products.

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Lymecycline
CAS:
- 992-21-2
Lymecycline
Formula:C₂₂H₂₃ClN₂O₈
Color and Shape:Dark Yellow
Molecular weight:478.8796
Ref: 47-218
100mg
211.00€
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(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid
CAS:
- 992-21-2
(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid
Formula:C₂₉H₃₈N₄O₁₀
Purity:95%
Molecular weight:602.63
Ref: 54-OR1120108
5mg
402.00€
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10mg
586.00€
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25mg
801.00€
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50mg
1,141.00€
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(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid
CAS:
- 992-21-2
Formula:C₂₉H₃₈N₄O₁₀
Purity:95%
Color and Shape:Solid
Molecular weight:602.6328
Ref: IN-DA01CC6C
25mg
592.00€
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50mg
949.00€
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Lymecycline
CAS:
- 992-21-2
Lymecycline (Mucomycin) is a tetracycline-class antibacterial agent that inhibits bacterial 30S ribosomal protein synthesis, exhibits pH-dependent release in an α-Fe₂O₃ nanocarrier drug delivery system, and can also serve as a template and signal conjugate for molecularly imprinted assays.
Formula:C₂₉H₃₈N₄O₁₀
Color and Shape:Solid
Molecular weight:602.64
Ref: TM-T20164
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Lymecycline-d8 (>80%)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 992-21-2
Stability Light Sensitive, Temperature Sensitive
Applications Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.
References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004),
Formula:C₂₉H₃₀D₈N₄O₁₀
Purity:>80%
Color and Shape:Neat
Molecular weight:610.68
Ref: TR-L487802
1mg
645.00€
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Lymecycline
CAS:
- 992-21-2
Formula:C₂₉H₃₈N₄O₁₀
Molecular weight:602.64
Ref: 4Z-L-237001
5mg
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10mg
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25mg
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50mg
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100mg
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+ Info
Lymecycline
CAS:
- 992-21-2
Lymecycline is a tetracycline antibiotic that has been shown to be effective in the treatment of inflammatory bowel disease, chronic arthritis, and experimental models of inflammatory reactions. Lymecycline inhibits epidermal growth factor (EGF) and its receptor EGF-R. This inhibition leads to reduced inflammation in the bowel. Lymecycline also has an anti-inflammatory effect on the skin, inhibiting reactive oxygen species (ROS) production from neutrophils and macrophages. It also reduces the symptoms of toxic epidermal necrolysis by preventing ROS production and reducing cytokines such as TNF-α and IL-1β. Lymecycline binds to magnesium ions, which are necessary for bacterial growth and replication. This binding leads to bacteriostatic activity against bacteria that are sensitive to lymecycline, including Mycobacterium tuberculosis and other infectious diseases. The histological
Formula:C₂₉H₃₈N₄O₁₀
Purity:Min. 85 Area-%
Color and Shape:Powder
Molecular weight:602.63 g/mol
Ref: 3D-FL164019
5mg
267.00€
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10mg
376.00€
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25mg
557.00€
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Lymecycline
CAS:
- 992-21-2
Formula:C₂₉H₃₈N₄O₁₀
Molecular weight:602.6
Ref: BE-RMCT114019
25mg
2,181.00€
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Lymecycline (85%)
CAS:
- 992-21-2
Stability Temperature sensitive
Applications A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.
References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004),
Formula:C₂₉H₃₈N₄O₁₀
Purity:85%
Color and Shape:Neat
Molecular weight:602.63
Ref: TR-L487800
5mg
209.00€
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10mg
306.00€
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100mg
823.00€
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Lymecycline
CAS:
- 992-21-2
Formula:C₂₉H₃₈N₄O₁₀
Molecular weight:602.64
Ref: ST-EA-CP-L64000
10mg
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25mg
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50mg
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100mg
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CAS 992-21-2

Lymecycline

Lymecycline

Ref: 47-218

(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid

Ref: 54-OR1120108

(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid

Ref: IN-DA01CC6C

Lymecycline

Ref: TM-T20164

Lymecycline-d8 (>80%)

Ref: TR-L487802

Lymecycline

Ref: 4Z-L-237001

Lymecycline

Ref: 3D-FL164019

Lymecycline

Ref: BE-RMCT114019

Lymecycline (85%)

Ref: TR-L487800

Lymecycline

Ref: ST-EA-CP-L64000