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CAS 99614-01-4

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Ondansetron hydrochloride

Description:
Ondansetron hydrochloride is a selective serotonin 5-HT3 receptor antagonist primarily used as an antiemetic to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It is a white to off-white crystalline powder that is soluble in water and has a molecular formula that reflects its complex structure. The substance exhibits a high affinity for the 5-HT3 receptors, blocking the action of serotonin, which is responsible for triggering nausea and vomiting. Ondansetron hydrochloride is typically administered orally or intravenously, and its pharmacokinetics include rapid absorption and a relatively short half-life, necessitating multiple doses in some treatment regimens. The compound is generally well-tolerated, with common side effects including headache, constipation, and dizziness. It is important to note that while effective, ondansetron should be used with caution in patients with certain medical conditions, and its use during pregnancy should be evaluated carefully. Overall, ondansetron hydrochloride is a critical medication in managing chemotherapy-induced nausea and vomiting, contributing significantly to patient comfort and quality of life during cancer treatment.
Formula:C18H19N3O·ClH
InChI:InChI=1S/C18H19N3O.ClH/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H
InChI key:InChIKey=MKBLHFILKIKSQM-UHFFFAOYSA-N
SMILES:O=C1C=2C=3C(N(C)C2CCC1CN4C(C)=NC=C4)=CC=CC3.Cl
Synonyms:
  • (+-)-2,3-Dihydro-9-Methyl-3-((2-Methylimidazol-1-Yl)Methyl)Carbazol-4(1H)-One Monohydrochloride Dihydrate
  • 1,2,3,4-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-9H-carbazol-4-one hydrochloride
  • 1,2,3,9-Tetrahydro-9-Methyl-3-[(2-Methyl-1H-Imidazol-1-Yl)Methyl]-4H-Carbazol-4-One Hydrochloride Dihydrate
  • 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride (1:1)
  • 4H-Carbazol-4-One, 1,2,3,9-Tetrahydro-9-Methyl-3-((2-Methyl-1H-Imidazol-1-Yl)Methyl)-, Monohydrochloride, (+-)-, Dihydrate
  • 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-, monohydrochloride
  • 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, hydrochloride (1:1)
  • 9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-4H-carbazol-4-one monohydrochloride
  • 9-Methyl-3-[(2-Methylimidazol-1-Yl)Methyl]-2,3-Dihydro-1H-Carbazol-4-One Dihydrate Hydrochloride
  • 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride (1:1)
  • See more synonyms
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