Ion Channel

Nateglinide is used to treat type 2 diabetes mellitus as an oral hypoglycemic, insulinotropic agent. It is a blocker of ATP-dependent potassium channels and works by increasing the body's production of insulin, which lowers blood glucose levels. Nateglinide has been shown to be effective in reducing postprandial blood glucose levels in patients with type 2 diabetes who have not responded well to other treatments. The effects of nateglinide are reversible.

Serotonin 5-HT3 receptor antagonist; anti-emetic

Amlodipine is a synthetic vasodilator that has antihypertensive and antianginal affects. It belongs to a group of drugs called calcium channel blockers and works by blocking the movement of calcium ions into cells in the heart and blood vessels. It is used for the treatment of hypertension and angina.

Dofetilide belongs to the class of antiarrhythmic agents. It is a class III antiarrhythmic agent, which acts by blocking the potassium ion channels in the heart. It is used for the management of normal sinus rhythm and in atrial fibrillation. In vitro studies have shown that Dofetilide can prevent arrhythmias resulting from experimental models of congestive heart failure and can prevent re-entry mechanisms that lead to tachycardia.

Antagonist of serotonin receptors 5-HT3

Sodium channel blocker; anti-arrhythmic agent

nAChRs nicotinic receptor antagonist; neuromuscular-blocking agent