Amino Acid Derivatives

<p>L-Homoglutamine is a non-essential amino acid that is an important part of the urea cycle. It also plays a role in protein synthesis, as well as in transfer reactions, such as the conversion of ammonia to urea. L-Homoglutamine has been shown to be an inhibitor of binding to collagenase, which may have therapeutic applications for diseases such as rheumatoid arthritis. This amino acid has been used in enzyme preparations and has been found to have biological properties that are similar to those of other carbonyl amino acids (e.g., L-glutamic acid).</p>

<p>L-gamma-glutamyl-L-threonine is a compound in the sphingolipid metabolism pathway. It has been shown to be a regulator of acidic phospholipids and fatty acids. L-gamma-glutamyl-L-threonine is found in human urine at high concentrations and has demonstrated antibacterial activity against gram negative bacteria. The analog, L-threo-gamma-glutamyltyrosine, was shown to have anticancer activity against leukemia cells in vitro.</p>

<p>Boc-Phe-Pro-OH is an opioid receptor agonist. It binds to the δ opioid receptors and activates them, which leads to analgesic effects. Boc-Phe-Pro-OH also has antibacterial properties and can be used for the treatment of bacterial infections. This compound may also have antiinflammatory properties that are mediated by its ability to inhibit prostaglandin synthesis. Boc-Phe-Pro-OH has been shown to possess a high affinity for the μ opioid receptor, but does not activate this receptor subtype.</p>

<p>Boc-Asp-Gly-Oet is a versatile building block that is used in the synthesis of complex compounds. It is also a useful reagent, speciality chemical, and reaction component. Boc-Asp-Gly-Oet can be used as an intermediate for the synthesis of other compounds or as a scaffold for drug design. This compound has high purity and quality, making it a useful building block for research and development.</p>

<p>N-alpha-Acetyl-L-arginine methyl ester hydrochloride is an enzyme that catalyzes the conversion of arginine to citrulline. It is a part of a group of enzymes called kallikreins. Kinetic constants for this enzyme have been determined in both porcine and human pancreatic preparations. The efficiency of this enzyme has been found to be increased in the presence of L-phenylalanine, and it was found that the C-terminal subsite is responsible for this effect.</p>

<p>Z-Val-Ala-Asp fluoromethyl ketone (Z-VAD-fmk) is a pan-caspase inhibitor that is widely used in research studies. It is a synthetic compound that mimics the structure of natural caspase substrates and irreversibly inhibits caspase activity. Z-VAD-fmk has been shown to have anti-apoptotic properties, preventing programmed cell death in various experimental models. This compound is commonly used in studies investigating the role of caspases in cell death pathways and as a tool for evaluating the efficacy of potential therapeutic interventions. Z-VAD-fmk has also been studied for its potential as an adjuvant therapy in various diseases, including cancer and neurodegenerative disorders.</p>

<p>Z-Arg(Z)2-OH can be used in the assay to screen proteolytic activities in mite homogenates.</p>

<p>Fmoc-Asp(OtBu)-Thr(psi(Me,Me)pro)-OH is a dipeptide.</p>

<p>Tyrosyl-glycyl-glycine: tripeptide with L-tyrosine, two glycines, formed by enkephalinase.</p>

<p>Glycine is a buffering agent that can be used in electrophoresis for protein samples. It has an optimal pH range of 2.2-3.6 and a pKa of 2.35.</p>

<p>Leucylarginine hinders antinociception induced by L-arginine.</p>

<p>Sodium lauroyl glutamate (Acylglutamate LS-11) is an amino acid detergent and increases the solubility of long-chain alkyl gallates such as alkyl gallates.</p>

<p>Applications H-Thr-Leu-OH(cas# 50299-12-2) is a useful research chemical.<br></p>

<p>Applications Fmoc-L-Leu-OH-d10 is the labeled analogue of Fmoc-L-Leu-OH (F625015), an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.<br>References Haochen, W., et al.: J. Cell. Biochem., 114, 1969 (2013)<br></p>

<p>Applications Asp-Glu-Ala-Met-Met-Gln Trifluoroacetic Acid Salt is a custom peptide sequence.<br></p>