EGFR
EGFR (epidermal growth factor receptor) inhibitors are compounds that block the signaling of EGFR, a receptor that is often overexpressed in various cancers and plays a critical role in angiogenesis. EGFR inhibitors are used to prevent tumor growth and metastasis by disrupting the pathways that promote blood vessel formation in tumors. These inhibitors are widely used in cancer research and therapy. At CymitQuimica, we offer a diverse selection of high-quality EGFR inhibitors to support your research in oncology and angiogenesis.
Found 572 products of "EGFR"
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HKI-357 dimaleate
CAS:HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.Formula:C39H37ClFN5O11Color and Shape:SolidMolecular weight:806.2EGFR/HER2-IN-2
CAS:EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).Formula:C26H23N5O3Color and Shape:SolidMolecular weight:453.49UNC-CA359
CAS:UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.Formula:C18H14ClN3O2Color and Shape:SolidMolecular weight:339.78EGFR T790M/L858R-IN-5
CAS:EGFR T790M/L858R-IN-5 (example 52) functions as a potent EGFR T790M/L858R inhibitor, demonstrating a 92.9% inhibition rate at a concentration of 0.05 μM [1].Formula:C28H31N9OMolecular weight:509.61CAY10717
CAS:CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.Formula:C29H25F3N6O3Color and Shape:SolidMolecular weight:562.54(E/Z)-CP-724714
CAS:(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Formula:C27H27N5O3Purity:98%Color and Shape:SolidMolecular weight:469.54EGFR/HER2-IN-9
CAS:EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFRFormula:C25H25ClFN5O4Color and Shape:SolidMolecular weight:513.95EGFR-IN-54
CAS:EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.Formula:C17H14N4O4S3Color and Shape:SolidMolecular weight:434.51EGFR-IN-21
CAS:EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Formula:C36H44BrN10O2PColor and Shape:SolidMolecular weight:759.68(E/Z)-AG490
CAS:(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.Formula:C17H14N2O3Color and Shape:SolidMolecular weight:294.3EGFR-IN-75
EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.Formula:C10H6N6S2Color and Shape:SolidMolecular weight:274.32EGFR-IN-53
CAS:EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.34EGFR-IN-28
CAS:EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .Formula:C31H39BrN10O3SColor and Shape:SolidMolecular weight:711.68Tarlox-TKI
CAS:Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Formula:C19H18BrClN6OPurity:97.03%Color and Shape:SolidMolecular weight:461.74BAY 2476568
CAS:BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).Formula:C24H27FN4O4Color and Shape:SolidMolecular weight:454.49LDC0496
CAS:LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.Formula:C32H35N5O3Color and Shape:SolidMolecular weight:537.65EGFR-IN-67
CAS:EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].Formula:C18H17N3SColor and Shape:SolidMolecular weight:307.41Lavendustin C6
CAS:Lavendustin C6 is a effective tyrosine kinase inhibitor.Formula:C20H25NO5Color and Shape:SolidMolecular weight:359.42PDZ1i
CAS:PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.Formula:C28H26N8O4Color and Shape:SolidMolecular weight:538.56Nazartinib mesylate
CAS:Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).Formula:C27H35ClN6O5SPurity:98%Color and Shape:SolidMolecular weight:591.12EGFR-IN-73
CAS:EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Formula:C19H17ClFN3O4Purity:98%Color and Shape:SolidMolecular weight:405.81Antiproliferative agent-34
CAS:Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Formula:C27H27N7O5Purity:98%Color and Shape:SolidMolecular weight:529.55EGFR-IN-89
CAS:EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM againstFormula:C26H31FN8O2SPurity:98%Color and Shape:SolidMolecular weight:538.64NSC81111
CAS:NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].Formula:C19H16O4Color and Shape:SolidMolecular weight:308.33EGFR-IN-50
CAS:EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.Formula:C24H26BrN3O4S2Color and Shape:SolidMolecular weight:564.51EGFR-IN-16
CAS:EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.
Formula:C16H11NO3Purity:98%Color and Shape:SolidMolecular weight:265.26Tyrphostin AG 112
CAS:Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Formula:C13H8N4OPurity:99.14%Color and Shape:SolidMolecular weight:236.23NSC114126
CAS:NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.Formula:C22H20O4Color and Shape:SolidMolecular weight:348.39MS 39
CAS:MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.Formula:C55H71ClFN9O7SColor and Shape:SolidMolecular weight:1056.72DBPR112
CAS:DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Formula:C32H31N5O3Purity:99.25%Color and Shape:SolidMolecular weight:533.62Gefitinib N-oxide
CAS:Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.Formula:C22H24ClFN4O4Purity:98%Color and Shape:SolidMolecular weight:462.9Epertinib
CAS:Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).Formula:C30H27ClFN5O3Purity:98%Color and Shape:SolidMolecular weight:560.02RTC-5
CAS:RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.Formula:C24H22ClF3N2O3SPurity:98.14%Color and Shape:SolidMolecular weight:510.96Ref: TM-T12777
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CAS:SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Formula:C18H20O5Purity:99.64%Color and Shape:SolidMolecular weight:316.35EGFR-IN-2
CAS:EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.Formula:C26H33N9O3SPurity:98.52% - 99.79%Color and Shape:SolidMolecular weight:551.66Nimotuzumab
CAS:Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).Purity:95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:147.64 kDaEGFR-IN-68
CAS:EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.Formula:C24H22N2OColor and Shape:SolidMolecular weight:354.44JBJ-04-125-02
CAS:JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Formula:C29H26FN5O3SPurity:98%Color and Shape:SolidMolecular weight:543.61BKI-1369
CAS:BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Formula:C23H27N7OColor and Shape:SolidMolecular weight:417.51EGFR-IN-64
CAS:EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.Formula:C20H21N3O3Color and Shape:SolidMolecular weight:351.4GW 583340 dihydrochloride
CAS:GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Formula:C28H27Cl3FN5O3S2Purity:98.80%Color and Shape:SolidMolecular weight:671.03JNJ28871063 hydrochloride
CAS:ErbB receptor family inhibitorFormula:C24H28Cl2N6O3Purity:98%Color and Shape:SolidMolecular weight:519.42Mutated EGFR-IN-3
CAS:Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Formula:C31H29FN4O2Purity:98%Color and Shape:SolidMolecular weight:508.59Mutated EGFR-IN-2
CAS:Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Formula:C29H35FN8O3Purity:98%Color and Shape:SolidMolecular weight:562.64EGFR-IN-5
CAS:EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.
Formula:C31H38FN9OPurity:98.17%Color and Shape:SolidMolecular weight:571.69EGFR mutant-IN-2
CAS:EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].Formula:C27H27F3N6O2SColor and Shape:SolidMolecular weight:556.6Selatinib
CAS:Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.Formula:C29H26ClFN4O3SPurity:98.00%Color and Shape:SolidMolecular weight:565.06Tyrphostin 51
CAS:Tyrphostin 51 is an effective inhibitor of EGFR kinase.Formula:C13H8N4O3Purity:98%Color and Shape:SolidMolecular weight:268.23EGA
CAS:EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.Formula:C16H16BrN3OPurity:98% - 99.6%Color and Shape:SolidMolecular weight:346.22DS21360717
CAS:DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.Formula:C21H23N7OPurity:98%Color and Shape:SolidMolecular weight:389.45
