ASK
ASK (Apoptosis Signal-regulating Kinase) inhibitors target the ASK family of kinases, which are critical regulators of apoptosis and stress response pathways. ASK kinases are involved in the activation of apoptosis in response to various stress signals, including oxidative stress and DNA damage. By inhibiting ASK, these compounds can modulate apoptotic signaling, providing valuable tools for research into cell death, cancer, and neurodegenerative diseases. At CymitQuimica, we offer a range of high-quality ASK inhibitors to support your research in apoptosis, cell signaling, and disease mechanisms.
Found 13 products for "ASK".
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
dASK1-VHL
dASK1-VHL is an orally active PROTAC degrader targeting ASK1. It effectively binds to VHL, promoting the selective degradation of ASK1. By reducing ASK1 protein levels, dASK1-VHL inhibits the activation of p38 MAPK and decreases liver lipid content, offering new insights for MASH research.Color and Shape:Odour SolidASK1-IN-12
ASK1-IN-12 is an ASK1 inhibitor with an IC50 of 6.3 nM. It effectively suppresses the activation of the ASK1-p38/JNK pathway induced by TNF-α. Additionally, ASK1-IN-12 reduces cholesterol elevation and lipid droplet accumulation induced by free fatty acids, improving hepatic steatosis. This compound is valuable for research on non-alcoholic steatohepatitis (NASH).dASK1
CAS:dASK1 is a selective CRBN-based PROTAC degrader targeting apoptosis signal-regulating kinase 1 (ASK1). It forms a stable ternary complex with ASK1, facilitating its rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 exhibits strong ASK1 degradation capabilities and is applicable for hepatitis research.Formula:C38H38F2N10O8Color and Shape:SolidMolecular weight:800.77Anti-DBF4 Antibody (2Q22)
Anti-DBF4 Antibody (2Q22) is an antibody targeting DBF4. Anti-DBF4 Antibody (2Q22) can be used in ELISA, WB, IF Recommended dilution: WB:1:500-1:2000, IF:1:50-1:200.Color and Shape:Odour LiquidASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Formula:C19H19N9O2Purity:99.92%Color and Shape:White SolidMolecular weight:405.41MSC 2032964A
CAS:MSC 2032964A: Potent, selective ASK1 inhibitor, IC50=93 nM, oral, brain-permeable, curbs neuroinflammation, blocks LPS-induced ASK1/p38 activation.Formula:C16H13F3N6OPurity:99.76%Color and Shape:SolidMolecular weight:362.31Ref: TM-T33514
1mg79.00€2mg92.00€5mg149.00€1mL*10mM (DMSO)168.00€10mg227.00€25mg371.00€50mg530.00€100mg713.00€200mg982.00€ASK1 ligand 1
CAS:ASK1ligand 1 is a binding ligand for ASK1 and can be utilized to synthesize PROTACs such as dASK1-VHL.Formula:C17H16F2N6OColor and Shape:SolidMolecular weight:358.35ASK1-IN-8
CAS:ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM. In a mouse liver injury model induced by Acetaminophen, ASK1-IN-8 significantly reduces plasma alanine aminotransferase (ALT) levels, offering liver protection. This compound is useful for research in liver disease-related fields.Formula:C26H32N8O2Color and Shape:SolidMolecular weight:488.585CDK8/19-IN-1
CAS:CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).Formula:C19H18N4O4S2Purity:98%Color and Shape:SolidMolecular weight:430.5ASK1-IN-9
CAS:ASK1-IN-9 (Compound 3) is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of less than 200 nM. It is applicable for inflammation research.Formula:C21H20N6O2Molecular weight:388.43ASK1-IN-11
CAS:ASK1-IN-11 (Compound 7) is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of less than 200 nM. It also exhibits inhibitory activity against TNF-α, MYLK/MLCK kinase, and the hERG potassium ion channel. ASK1-IN-11 can be utilized in inflammation research.Formula:C23H22N6O3Molecular weight:430.47ASK1-IN-10
CAS:ASK1-IN-10 (Compound 27) is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of less than 200 nM. It also exhibits inhibitory activity on the hERG potassium channel. ASK1-IN-10 is utilized in inflammation research.Formula:C22H19N7OMolecular weight:397.44ASK1-IN-7
CAS:ASK1-IN-7 (Compound 4c) is an ASK1 inhibitor and a derivative of the ASK1 inhibitor scaffold 5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-4-one. This compound is potentially applicable in research involving ASK1 signaling pathways, including studies on cellular stress response, inflammatory response, neurodegenerative diseases, and cardiovascular diseases.Formula:C13H8N2O2S2Color and Shape:SolidMolecular weight:288.345
