Mdm2
Mdm2 inhibitors target the Mdm2 protein, which is an E3 ubiquitin ligase that negatively regulates the tumor suppressor p53. Mdm2 promotes the degradation of p53, thereby preventing apoptosis in cells that should undergo cell death. Inhibiting Mdm2 stabilizes p53, enhancing its tumor-suppressing activity and promoting apoptosis in cancer cells. Mdm2 inhibitors are crucial in cancer research and therapy, particularly for cancers with intact p53 pathways. At CymitQuimica, we provide high-quality Mdm2 inhibitors to support your research in cancer biology, apoptosis, and therapeutic development.
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MD-224
CAS:2136247-12-4
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) …
Formula:
C48H43Cl2FN6O6
Purity:
100% - 99.07%
Color and Shape:
Solid
Molecular weight:
889.8
Ref: TM-T11980
| 1mg | 69.00 € | ||
| 5mg | 149.00 € | ||
| 10mg | 270.00 € | ||
| 25mg | 499.00 € | ||
| 50mg | 724.00 € | ||
| 1mL*10mM (DMSO) | 165.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor …
Formula:
C41H42Cl2FN5O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
774.71
Ref: TM-T12027
| 100mg | To inquire | ||
| 500mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
p53-Mdm2 inhibitor 4
CAS:350678-63-6
p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.
Formula:
C23H20FN3O3
Purity:
99.63%
Color and Shape:
Soild
Molecular weight:
405.42
Ref: TM-T67698
| 5mg | 35.00 € | ||
| 10mg | 52.00 € | ||
| 25mg | 82.00 € | ||
| 50mg | 110.00 € | ||
| 100mg | 164.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Amifostine thiol
CAS:31098-42-7
Amifostine thiol (WR-1065), an active Amifostine metabolite, is a radioprotective cytoprotectant that activates p53 via …
Formula:
C5H14N2S
Purity:
≥95.0%
Color and Shape:
Liquid
Molecular weight:
134.24
Ref: TM-T37538
| 2mg | 35.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
PK11007
CAS:874146-69-7
PK11007 is an anti-p53 drug.
Formula:
C15H11ClFN5O3S2
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
427.86
Ref: TM-T7703
| 1mg | 38.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 102.00 € | ||
| 25mg | 185.00 € | ||
| 50mg | 277.00 € | ||
| 100mg | 408.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PhiKan 083
CAS:880813-36-5
PhiKan 083 is a carbazole derivative
Formula:
C16H18N2
Purity:
98.2%
Color and Shape:
Solid
Molecular weight:
238.33
Ref: TM-T16523L
| 1mg | 35.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 110.00 € | ||
| 25mg | 232.00 € | ||
| 50mg | 326.00 € | ||
| 100mg | 458.00 € | ||
| 500mg | 983.00 € | ||
| 1mL*10mM (DMSO) | 75.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
UC2288
CAS:1394011-91-6
UC2288, a Sorafenib-based p21 attenuator, reduces p21 levels without affecting its stability.
Formula:
C20H18ClF6N3O2
Purity:
99.75%
Color and Shape:
Solid
Molecular weight:
481.82
Ref: TM-T9698
| 1mg | 48.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 142.00 € | ||
| 25mg | 258.00 € | ||
| 50mg | 386.00 € | ||
| 100mg | 477.00 € | ||
| 200mg | 593.00 € | ||
| 500mg | 862.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Idasanutlin
CAS:1229705-06-9
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
Formula:
C31H29Cl2F2N3O4
Purity:
98.85% - 99.86%
Color and Shape:
Solid
Molecular weight:
616.48
Ref: TM-T6254
| 2mg | 40.00 € | ||
| 5mg | 60.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 156.00 € | ||
| 50mg | 222.00 € | ||
| 100mg | 369.00 € | ||
| 500mg | 866.00 € | ||
| 1mL*10mM (DMSO) | 83.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
NVP-CGM097
CAS:1313363-54-0
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
Formula:
C38H47ClN4O4
Purity:
98.92%
Color and Shape:
Solid
Molecular weight:
659.26
Ref: TM-TQ0231
| 1mg | 86.00 € | ||
| 5mg | 204.00 € | ||
| 10mg | 337.00 € | ||
| 25mg | 513.00 € | ||
| 50mg | 674.00 € | ||
| 100mg | 932.00 € | ||
| 1mL*10mM (DMSO) | 297.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SP-141
CAS:1253491-42-7
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
Formula:
C22H16N2O
Purity:
98.01%
Color and Shape:
Solid
Molecular weight:
324.38
Ref: TM-T21773
| 1mg | 45.00 € | ||
| 5mg | 92.00 € | ||
| 10mg | 126.00 € | ||
| 25mg | 268.00 € | ||
| 50mg | 447.00 € | ||
| 100mg | 641.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CP-31398 dihydrochloride
CAS:1217195-61-3
CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes …
Formula:
C22H28Cl2N4O
Purity:
98.23%
Color and Shape:
Solid
Molecular weight:
435.4
Ref: TM-T21648
| 5mg | 49.00 € | ||
| 10mg | 72.00 € | ||
| 25mg | 129.00 € | ||
| 50mg | 200.00 € | ||
| 100mg | 326.00 € | ||
| 200mg | 453.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
MX69
CAS:1005264-47-0
MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
Formula:
C27H26N2O4S
Purity:
97.27% - 99.57%
Color and Shape:
Solid
Molecular weight:
474.57
Ref: TM-T3653
| 1mg | 36.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 119.00 € | ||
| 25mg | 225.00 € | ||
| 50mg | 363.00 € | ||
| 100mg | 541.00 € | ||
| 500mg | 1,170.00 € | ||
| 1mL*10mM (DMSO) | 82.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
NSC 66811
CAS:6964-62-1
NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.
Formula:
C23H20N2O
Purity:
96.94%
Color and Shape:
Solid
Molecular weight:
340.42
Ref: TM-T21578
| 1mg | 35.00 € | ||
| 2mg | 47.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 91.00 € | ||
| 25mg | 149.00 € | ||
| 50mg | 215.00 € | ||
| 100mg | 321.00 € | ||
| 200mg | 467.00 € | ||
| 1mL*10mM (DMSO) | 76.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Navtemadlin
CAS:1352066-68-2
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 …
Formula:
C28H35Cl2NO5S
Purity:
95.55% - 98.86%
Color and Shape:
Solid
Molecular weight:
568.55
Ref: TM-TQ0127
| 1mg | 72.00 € | ||
| 2mg | 92.00 € | ||
| 5mg | 143.00 € | ||
| 10mg | 213.00 € | ||
| 25mg | 432.00 € | ||
| 50mg | 634.00 € | ||
| 100mg | 907.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Tenovin-1
CAS:380315-80-0
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which …
Formula:
C20H23N3O2S
Purity:
99.44%
Color and Shape:
Solid
Molecular weight:
369.48
Ref: TM-T1919
| 10mg | 54.00 € | ||
| 25mg | 82.00 € | ||
| 50mg | 108.00 € | ||
| 100mg | 188.00 € | ||
| 1mL*10mM (DMSO) | 43.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
RITA
CAS:213261-59-7
RITA (NSC-652287) forms DNA-DNA/protein cross-links without DNA breaks; disrupts p53/Mdm2 like nutlin-3.
Formula:
C14H12O3S2
Purity:
97.76% - 98.85%
Color and Shape:
Solid
Molecular weight:
292.37
Ref: TM-T1798
| 1mg | 35.00 € | ||
| 2mg | 45.00 € | ||
| 5mg | 66.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 184.00 € | ||
| 50mg | 338.00 € | ||
| 100mg | 497.00 € | ||
| 200mg | 699.00 € | ||
| 500mg | 1,067.00 € | ||
| 1mL*10mM (DMSO) | 90.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Nutlin-3b
CAS:675576-97-3
Nutlin-3b, a less potent (+)-enantiomer of Nutlin-3, inhibits p53/MDM2 at IC50: 13.6 μM, 150x weaker …
Formula:
C30H30Cl2N4O4
Purity:
98.83%
Color and Shape:
Solid
Molecular weight:
581.49
Ref: TM-T6614
| 1mg | 42.00 € | ||
| 2mg | 55.00 € | ||
| 5mg | 89.00 € | ||
| 10mg | 136.00 € | ||
| 25mg | 254.00 € | ||
| 50mg | 421.00 € | ||
| 100mg | 609.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Kevetrin hydrochloride
CAS:66592-89-0
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein …
Formula:
C5H10ClN3S
Purity:
99.38% - 99.93%
Color and Shape:
Solid
Molecular weight:
179.67
Ref: TM-T3184
| 5mg | 45.00 € | ||
| 10mg | 66.00 € | ||
| 25mg | 109.00 € | ||
| 50mg | 170.00 € | ||
| 100mg | 282.00 € | ||
| 1mL*10mM (DMSO) | 66.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Tenovin-6 Hydrochloride
CAS:1011301-29-3
Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.
Formula:
C25H35ClN4O2S
Purity:
100%
Color and Shape:
Solid
Molecular weight:
491.09
Ref: TM-T8480
| 1mg | 39.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 139.00 € | ||
| 50mg | 224.00 € | ||
| 100mg | 372.00 € | ||
| 1mL*10mM (DMSO) | 73.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
XI-006
CAS:58131-57-0
NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and …
Formula:
C11H13N5O4
Purity:
99.12%
Color and Shape:
Solid
Molecular weight:
279.25
Ref: TM-T6610
| 1mg | 55.00 € | ||
| 2mg | 80.00 € | ||
| 5mg | 118.00 € | ||
| 10mg | 183.00 € | ||
| 25mg | 423.00 € | ||
| 50mg | 625.00 € | ||
| 100mg | 892.00 € | ||
| 500mg | 1,794.00 € | ||
| 1mL*10mM (DMSO) | 114.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
