Mdm2
Mdm2 inhibitors target the Mdm2 protein, which is an E3 ubiquitin ligase that negatively regulates the tumor suppressor p53. Mdm2 promotes the degradation of p53, thereby preventing apoptosis in cells that should undergo cell death. Inhibiting Mdm2 stabilizes p53, enhancing its tumor-suppressing activity and promoting apoptosis in cancer cells. Mdm2 inhibitors are crucial in cancer research and therapy, particularly for cancers with intact p53 pathways. At CymitQuimica, we provide high-quality Mdm2 inhibitors to support your research in cancer biology, apoptosis, and therapeutic development.
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RO8994
CAS:1309684-94-3
RO8994: potent MDM2 spiroindolinone inhibitor, IC50: 20 nM (proliferation), 5 nM (binding).
Formula:
C31H31Cl2FN4O4
Purity:
98.87% - 99.31%
Color and Shape:
Solid
Molecular weight:
613.51
Ref: TM-T3517
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 126.00 € | ||
| 25mg | 228.00 € | ||
| 50mg | 360.00 € | ||
| 100mg | 534.00 € | ||
| 1mL*10mM (DMSO) | 104.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SJ-172550
CAS:431979-47-4
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
Formula:
C22H21ClN2O5
Purity:
99.87%
Color and Shape:
Solid
Molecular weight:
428.87
Ref: TM-T16888
| 2mg | 43.00 € | ||
| 5mg | 64.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 183.00 € | ||
| 50mg | 349.00 € | ||
| 100mg | 599.00 € | ||
| 500mg | 1,234.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Tenovin-6
CAS:1011557-82-6
Tenovin-6 is a p53 transcriptional activity agonist.
Formula:
C25H34N4O2S
Purity:
100% - 97.71%
Color and Shape:
Solid
Molecular weight:
454.63
Ref: TM-T1818
| 1mg | 42.00 € | ||
| 2mg | 55.00 € | ||
| 5mg | 76.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 154.00 € | ||
| 50mg | 227.00 € | ||
| 100mg | 384.00 € | ||
| 500mg | 915.00 € | ||
| 1mL*10mM (DMSO) | 79.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
RG7112
CAS:939981-39-2
RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
Formula:
C38H48Cl2N4O4S
Purity:
99.17% - 99.92%
Color and Shape:
Solid
Molecular weight:
727.78
Ref: TM-T6965
| 1mg | 48.00 € | ||
| 2mg | 64.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 166.00 € | ||
| 25mg | 320.00 € | ||
| 50mg | 485.00 € | ||
| 100mg | 703.00 € | ||
| 500mg | 1,468.00 € | ||
| 1mL*10mM (DMSO) | 154.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SAR405838
CAS:1303607-60-4
MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. …
Formula:
C29H34Cl2FN3O3
Purity:
98.04%
Color and Shape:
Solid
Molecular weight:
562.5
Ref: TM-T6585
| 1mg | 49.00 € | ||
| 2mg | 90.00 € | ||
| 5mg | 130.00 € | ||
| 10mg | 209.00 € | ||
| 25mg | 412.00 € | ||
| 50mg | 607.00 € | ||
| 100mg | 860.00 € | ||
| 500mg | 1,747.00 € |
Estimated delivery in United States, on Wednesday 8 Jan 2025
RO-5963
CAS:1416663-77-8
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, …
Formula:
C24H21ClF2N4O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
518.9
Ref: TM-T16771
| 1mg | 102.00 € | ||
| 5mg | 322.00 € | ||
| 10mg | 464.00 € | ||
| 25mg | 708.00 € | ||
| 50mg | 917.00 € | ||
| 100mg | 1,272.00 € | ||
| 500mg | 2,572.00 € | ||
| 1mL*10mM (DMSO) | 369.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
MI-1061
CAS:1410737-34-6
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
Formula:
C30H26Cl2FN3O4
Color and Shape:
Solid
Molecular weight:
582.45
Ref: TM-T12031
| 25mg | 3,350.00 € | ||
| 50mg | To inquire | ||
| 100mg | To inquire |
Estimated delivery in United States, on Wednesday 22 Jan 2025
p53-MDM2-IN-1
CAS:381717-91-5
p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value …
Formula:
C23H20ClN3O3
Purity:
98.3%
Color and Shape:
Soild
Molecular weight:
421.88
Ref: TM-T72026
| 1mg | 182.00 € | ||
| 5mg | 455.00 € | ||
| 10mg | 664.00 € | ||
| 25mg | 1,019.00 € | ||
| 50mg | 1,374.00 € | ||
| 100mg | 1,850.00 € | ||
| 500mg | 3,686.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
RDR03871
CAS:286008-51-3
RDR03871 is an MDM2 inhibitor.
Formula:
C18H16ClF3N6
Purity:
97.78%
Color and Shape:
Solid
Molecular weight:
408.81
Ref: TM-T28509
| 1mg | 113.00 € | ||
| 2mg | 169.00 € | ||
| 5mg | 249.00 € | ||
| 10mg | 366.00 € | ||
| 25mg | 550.00 € | ||
| 50mg | 769.00 € | ||
| 100mg | 1,049.00 € | ||
| 500mg | To inquire |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Brigimadlin
CAS:2095116-40-6
Brigimadlin (BI 907828) is an orally active and highly potent antagonist of the E3 ubiquitin-protein …
Formula:
C31H25Cl2FN4O3
Purity:
98.17%
Color and Shape:
Liquid
Molecular weight:
591.46
Ref: TM-T69923
| 1mg | 252.00 € | ||
| 5mg | 551.00 € | ||
| 10mg | 831.00 € | ||
| 25mg | 1,437.00 € | ||
| 50mg | 1,872.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
AM-8735
CAS:1429386-01-5
AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
Formula:
C27H31Cl2NO6S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
568.51
Ref: TM-T14203
| 25mg | 1,688.00 € | ||
| 50mg | 2,225.00 € | ||
| 100mg | 2,897.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
Alrizomadlin
CAS:1818393-16-6
Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt …
Formula:
C34H38Cl2FN3O4
Purity:
98.69% - 98.79%
Color and Shape:
Solid
Molecular weight:
642.59
Ref: TM-T14303
| 1mg | 246.00 € | ||
| 5mg | 575.00 € | ||
| 10mg | 824.00 € | ||
| 25mg | 1,178.00 € | ||
| 50mg | 1,420.00 € | ||
| 100mg | 1,846.00 € | ||
| 1mL*10mM (DMSO) | 742.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
MA242
CAS:1049704-18-8
MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy …
Formula:
C26H21ClF3N3O5S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
579.98
Ref: TM-T11931
| 25mg | 2,106.00 € | ||
| 50mg | 2,785.00 € | ||
| 100mg | 3,739.00 € |
Estimated delivery in United States, on Wednesday 5 Mar 2025
Milademetan
CAS:1398568-47-2
Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, …
Formula:
C30H34Cl2FN5O4
Purity:
100%
Color and Shape:
Solid
Molecular weight:
618.53
Ref: TM-T12040
| 1mg | 172.00 € | ||
| 5mg | 507.00 € | ||
| 10mg | 736.00 € | ||
| 25mg | 1,012.00 € | ||
| 50mg | 1,420.00 € | ||
| 100mg | 1,837.00 € | ||
| 1mL*10mM (DMSO) | 36.00 € |
Estimated delivery in United States, on Wednesday 5 Mar 2025
