p53
p53 inhibitors target the p53 protein, a tumor suppressor that plays a crucial role in regulating the cell cycle, DNA repair, and apoptosis. While p53 is often mutated or inactivated in cancer cells, its inhibition is sometimes necessary to protect healthy cells from apoptosis during certain treatments. On the other hand, restoring p53 function in tumors can lead to cancer cell apoptosis. Research into p53 inhibitors is complex and significant for both understanding cancer mechanisms and developing new therapies. At CymitQuimica, we provide a selection of high-quality p53 inhibitors and modulators to support your research in cancer biology, apoptosis, and therapeutic development.
Found 62 products of "p53"
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Amifostine trihydrate
CAS:<p>Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.</p>Formula:C5H15N2O3PS·3H2OPurity:99.71% - 99.80%Color and Shape:SolidMolecular weight:268.27Leptomycin B
CAS:<p>Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.</p>Formula:C33H48O6Purity:97.10% - 99.04%Color and Shape:White Crystalline SolidMolecular weight:540.73BIX-01294 trihydrochloride
CAS:<p>BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.</p>Formula:C28H38N6O2·3HClPurity:99.41% - 99.95%Color and Shape:SolidMolecular weight:600.02Theaflavin 3,3′-digallate
CAS:<p>Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer</p>Formula:C43H32O20Purity:98.71% - 99.86%Color and Shape:SolidMolecular weight:868.7Nutlin-3a
CAS:<p>Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.</p>Formula:C30H30Cl2N4O4Purity:95.62% - 99.71%Color and Shape:SolidMolecular weight:581.49YK-3-237
CAS:<p>YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative</p>Formula:C19H21BO7Purity:99.47%Color and Shape:SolidMolecular weight:372.18O6-Benzylguanine
CAS:<p>O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.</p>Formula:C12H11N5OPurity:98.9%Color and Shape:Solid CrystallineMolecular weight:241.25UNC0224
CAS:<p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>Formula:C26H43N7O2Purity:99.80%Color and Shape:SolidMolecular weight:485.67NSC 146109 hydrochloride
CAS:<p>NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.</p>Formula:C17H17ClN2SPurity:99.28%Color and Shape:SolidMolecular weight:316.85UNC0321
CAS:<p>UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.</p>Formula:C27H45N7O3Purity:99.80%Color and Shape:SolidMolecular weight:515.69BML-259
CAS:<p>BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.</p>Formula:C14H16N2OSPurity:99.84%Color and Shape:SolidMolecular weight:260.35PDK4-IN-1 hydrochloride
CAS:<p>PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4, IC50 value = 84 nM).</p>Formula:C22H20ClN3O2Purity:99.67%Color and Shape:SolidMolecular weight:393.87
