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p53

p53

p53 inhibitors target the p53 protein, a tumor suppressor that plays a crucial role in regulating the cell cycle, DNA repair, and apoptosis. While p53 is often mutated or inactivated in cancer cells, its inhibition is sometimes necessary to protect healthy cells from apoptosis during certain treatments. On the other hand, restoring p53 function in tumors can lead to cancer cell apoptosis. Research into p53 inhibitors is complex and significant for both understanding cancer mechanisms and developing new therapies. At CymitQuimica, we provide a selection of high-quality p53 inhibitors and modulators to support your research in cancer biology, apoptosis, and therapeutic development.

Found 63 products of "p53"

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  • Amifostine trihydrate

    CAS:
    Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
    Formula:C5H15N2O3PS·3H2O
    Purity:99.71% - 99.80%
    Color and Shape:Solid
    Molecular weight:268.27

    Ref: TM-T6381

    5mg
    34.00€
    10mg
    52.00€
    25mg
    93.00€
    50mg
    117.00€
    100mg
    164.00€
    500mg
    376.00€
  • Leptomycin B

    CAS:
    Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.
    Formula:C33H48O6
    Purity:97.10% - 99.04%
    Color and Shape:White Crystalline Solid
    Molecular weight:540.73

    Ref: TM-T15735

    1mg
    202.00€
    2mg
    341.00€
    5mg
    620.00€
    10mg
    882.00€
    25mg
    1,320.00€
    50mg
    1,776.00€
    100mg
    2,403.00€
    1mL*10mM (DMSO)
    283.00€
  • BIX-01294 trihydrochloride

    CAS:
    BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.
    Formula:C28H38N6O2·3HCl
    Purity:99.41% - 99.95%
    Color and Shape:Solid
    Molecular weight:600.02

    Ref: TM-T1959

    2mg
    50.00€
    5mg
    67.00€
    10mg
    102.00€
    25mg
    182.00€
    50mg
    259.00€
    100mg
    447.00€
    200mg
    607.00€
    1mL*10mM (DMSO)
    105.00€
  • Theaflavin 3,3′-digallate

    CAS:
    Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer
    Formula:C43H32O20
    Purity:98.71% - 99.86%
    Color and Shape:Solid
    Molecular weight:868.70

    Ref: TM-T5429

    1mg
    87.00€
    5mg
    169.00€
    10mg
    268.00€
    25mg
    462.00€
    50mg
    647.00€
    100mg
    873.00€
    200mg
    1,153.00€
    1mL*10mM (DMSO)
    268.00€
  • Nutlin-3a

    CAS:
    Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.
    Formula:C30H30Cl2N4O4
    Purity:95.62% - 99.71%
    Color and Shape:Solid
    Molecular weight:581.49

    Ref: TM-T6023

    1mg
    50.00€
    2mg
    66.00€
    5mg
    90.00€
    10mg
    156.00€
    25mg
    254.00€
    50mg
    376.00€
    100mg
    557.00€
    1mL*10mM (DMSO)
    128.00€
  • YK-3-237

    CAS:
    YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative
    Formula:C19H21BO7
    Purity:99.47%
    Color and Shape:Solid
    Molecular weight:372.18

    Ref: TM-T9320

    2mg
    38.00€
    5mg
    57.00€
    10mg
    93.00€
    25mg
    170.00€
    50mg
    289.00€
    100mg
    507.00€
    200mg
    655.00€
    500mg
    1,018.00€
    1mL*10mM (DMSO)
    63.00€
  • NSC 66811

    CAS:
    NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.
    Formula:C23H20N2O
    Purity:96.94%
    Color and Shape:Solid
    Molecular weight:340.42

    Ref: TM-T21578

    5mg
    43.00€
    10mg
    58.00€
    25mg
    95.00€
    50mg
    128.00€
    100mg
    185.00€
    200mg
    269.00€
    1mL*10mM (DMSO)
    47.00€
  • O6-Benzylguanine

    CAS:
    O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
    Formula:C12H11N5O
    Purity:98.9%
    Color and Shape:Solid Crystalline
    Molecular weight:241.25

    Ref: TM-T7539

    25mg
    47.00€
    50mg
    64.00€
    100mg
    90.00€
    500mg
    210.00€
  • UNC0224

    CAS:
    UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.
    Formula:C26H43N7O2
    Purity:99.80%
    Color and Shape:Solid
    Molecular weight:485.67

    Ref: TM-T17203

    1mg
    34.00€
    5mg
    66.00€
    10mg
    99.00€
    25mg
    192.00€
    50mg
    334.00€
    100mg
    567.00€
    1mL*10mM (DMSO)
    102.00€
  • NSC 146109 hydrochloride

    CAS:
    NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.
    Formula:C17H17ClN2S
    Purity:99.28%
    Color and Shape:Solid
    Molecular weight:316.85

    Ref: TM-T12257

    5mg
    38.00€
    10mg
    56.00€
    1mL*10mM (DMSO)
    43.00€
  • UNC0321

    CAS:
    UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.
    Formula:C27H45N7O3
    Purity:99.80%
    Color and Shape:Solid
    Molecular weight:515.69

    Ref: TM-T17204

    1mg
    47.00€
    5mg
    93.00€
    10mg
    144.00€
    25mg
    274.00€
    50mg
    432.00€
    100mg
    622.00€
  • BML-259

    CAS:
    BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.
    Formula:C14H16N2OS
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:260.35

    Ref: TM-T36964

    5mg
    50.00€
    10mg
    85.00€
    25mg
    169.00€
    50mg
    279.00€
    100mg
    487.00€
    500mg
    1,035.00€
    1mL*10mM (DMSO)
    52.00€
  • PDK4-IN-1 hydrochloride

    CAS:
    PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4, IC50 value = 84 nM).
    Formula:C22H20ClN3O2
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:393.87

    Ref: TM-T12412L

    1mg
    70.00€
    5mg
    150.00€
    10mg
    215.00€
    25mg
    358.00€
    50mg
    515.00€
    100mg
    707.00€
    200mg
    1,009.00€
    1mL*10mM (DMSO)
    165.00€